A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial [0.03%]
富含多酚的地中海饮食改善表观遗传调控潜力：DIRECT PLUS随机对照试验
Anne Hoffmann,Anat Yaskolka Meir,Tobias Hagemann et al.
Anne Hoffmann et al.
Background: The capacity of a polyphenol-enriched diet to modulate the epigenome in vivo is partly unknown. Given the beneficial metabolic effects of a Mediterranean (MED) diet enriched in polyphenols and reduced in red/p...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2023 Aug:145:155594. DOI:10.1016/j.metabol.2023.155594 2023
Renin-independent aldosteronism and chronic kidney disease in diabetes: Observational and Mendelian randomization analyses [0.03%]
糖尿病肾素非依赖性醛固酮增多症与慢性肾脏病：观察性及孟德尔随机化研究分析
Jinbo Hu,Xiangjun Chen,Yi Luo et al.
Jinbo Hu et al.
Background: Renin-independent aldosteronism (RIA) describes the spectrum of autonomous aldosterone secretion from mild to overt. We aimed to explore whether RIA is causally associated with chronic kidney disease (CKD) in ...
Regulation of pericyte metabolic reprogramming restricts the AKI to CKD transition [0.03%]
调节周细胞代谢重组可限制急性肾损伤向慢性肾脏病的转变
Cheng Xu,Quan Hong,Kaiting Zhuang et al.
Cheng Xu et al.
Background and aims: Acute kidney injury (AKI) is associated with high morbidity and mortality and is recognized as a long-term risk factor for progression to chronic kidney disease (CKD). The AKI to CKD transition is cha...
Fructose induced KHK-C can increase ER stress independent of its effect on lipogenesis to drive liver disease in diet-induced and genetic models of NAFLD [0.03%]
果糖诱导的KHK-C可通过其对脂质合成的作用独立增加ER应激，驱动饮食诱导和遗传性NAFLD小鼠模型肝病进展
Se-Hyung Park,Robert N Helsley,Taghreed Fadhul et al.
Se-Hyung Park et al.
Non-alcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome, and is estimated to affect one billion individuals worldwide. An increased intake of a high-fat diet (HFD) and sugar-sweetened beverages are risk-fact...
Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis [0.03%]
生长激素受体(GHR)信号的直接和全身作用对肝脏糖酵解、从头脂质合成及胰岛素敏感性的影响以及与脂肪变性的关联
Mari C Vázquez-Borrego,Mercedes Del Río-Moreno,Maxim Pyatkov et al.
Mari C Vázquez-Borrego et al.
Background: Evidence is accumulating that growth hormone (GH) protects against the development of steatosis and progression of non-alcoholic fatty liver disease (NAFLD). GH may control steatosis indirectly by altering sys...
Unraveling the mystery of isocaloric endurance training - Influence of exercise modality, biological sex, and physical fitness [0.03%]
揭秘等热量耐力训练的奥秘——锻炼方式、生物性别和体能水平的影响分析
Thomas Leonhard Stöggl,Tilmann Strepp,Julia Blumkaitis et al.
Thomas Leonhard Stöggl et al.
Background: A sedentary lifestyle with low energy expenditure (EE) is associated with chronic diseases and mortality. Barriers such as "lack of time" or "lack of motivation" are common reasons why physical exercise is neg...
Mitochondria-SR interaction and mitochondrial fusion/fission in the regulation of skeletal muscle metabolism [0.03%]
线粒体融合分裂通过线粒体-内质网互作调控骨骼肌代谢
Mauricio Castro-Sepulveda,Rodrigo Fernández-Verdejo,Hermann Zbinden-Foncea et al.
Mauricio Castro-Sepulveda et al.
Mitochondria-endoplasmic/sarcoplasmic reticulum (ER/SR) interaction and mitochondrial fusion/fission are critical processes that influence substrate oxidation. This narrative review summarizes the evidence on the effects of substrate availa...
Association between the Finnish Diabetes Risk Score and cancer in middle-aged and older adults: Involvement of inflammation [0.03%]
芬兰糖尿病风险评分与中老年人癌症之间的关联：炎症的作用
Yu Peng,Peng Wang,Jianxiao Gong et al.
Yu Peng et al.
Background: Diabetes is associated with increased risk of common cancers. However, evidence of cancer risk in individuals with different diabetes risk is still scarce, and the underlying mechanism remains unknown. Therefo...
Diet, exercise, and pharmacotherapy for sarcopenia in people with diabetes [0.03%]
糖尿病患者的营养、锻炼和药物治疗以应对肌少症
Yoshitaka Hashimoto,Fuyuko Takahashi,Takuro Okamura et al.
Yoshitaka Hashimoto et al.
Diabetes prevalence is increasing rapidly in older people, and sarcopenia is prevalent as a novel complication, particularly in patients with type 2 diabetes mellitus (T2DM). Therefore, sarcopenia prevention and treatment in these people is...
Serum metabolomic profiling reveals potential biomarkers in systemic sclerosis [0.03%]
血清代谢组学特征鉴别系统性硬化病的生物标志物
Muyao Guo,Di Liu,Yu Jiang et al.
Muyao Guo et al.
Background: Systemic sclerosis (SSc) is a chronic and systemic autoimmune disease marked by the skin and visceral fibrosis. Metabolic alterations have been found in SSc patients; however, serum metabolomic profiling has n...