Targeting the dynamics of cancer metabolism in the era of precision oncology [0.03%]
精准肿瘤学时代的癌症代谢动力学靶向治疗
Peijie Zheng,Zihao Lin,Yuemin Ding et al.
Peijie Zheng et al.
Cancer metabolic reprogramming is a promising target for cancer therapy. The progression of tumors, including their growth, development, metastasis, and spread, is a dynamic process that varies over time and location. This means that the me...
Roles of malate and aspartate in gluconeogenesis in various physiological and pathological states [0.03%]
苹果酸和天冬氨酸在各种生理和病理状态下的糖异生作用
Milan Holeček
Milan Holeček
Gluconeogenesis, a pathway for glucose synthesis from non-carbohydrate substances, begins with the synthesis of oxaloacetate (OA) from pyruvate and intermediates of citric acid cycle in hepatocyte mitochondria. The traditional view is that ...
Glutaredoxin 1 regulates cholesterol metabolism and gallstone formation by influencing protein S-glutathionylation [0.03%]
谷氨酸核糖核酸酶1通过影响蛋白质S-谷胱甘肽化调节胆固醇代谢和胆石形成
Yan Xia,Ying Xu,Qinhui Liu et al.
Yan Xia et al.
Objective: Cholesterol gallstone disease (CGD) is closely related to cholesterol metabolic disorder. Glutaredoxin-1 (Glrx1) and Glrx1-related protein S-glutathionylation are increasingly being observed to drive various ph...
Increased expression of sodium-glucose cotransporter 2 and O-GlcNAcylation in hepatocytes drives non-alcoholic steatohepatitis [0.03%]
肝细胞中钠-葡萄糖共转运蛋白2和O-GlcNAc酰化的高表达驱动非酒精性steatohepatitis的发展
Hye Jin Chun,Eun Ran Kim,Minyoung Lee et al.
Hye Jin Chun et al.
Aims: Steatosis reducing effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors in non-alcoholic steatohepatitis (NASH) has been consistently reported in humans, but their mechanism remains uncertain. In this study,...
LncRNA Nron deficiency protects mice from diet-induced adiposity and hepatic steatosis [0.03%]
长链非编码RNA Nron缺乏可保护小鼠免受高脂饮食诱导的肥胖和肝脂肪变性的影响
Bing Liu,Yi Zhong,Dandan Huang et al.
Bing Liu et al.
Obesity, as a worldwide healthcare problem, has attracted more and more attention. Here we identify a long non-coding RNA NRON, which is highly conserved across species, as an important regulator of glucose/lipid metabolism and whole-body e...
Wang-Hsin Lee,Sonia M Najjar,C Ronald Kahn et al.
Wang-Hsin Lee et al.
Over 65 % of people with obesity display the metabolic-associated fatty liver disease (MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The development and progression of MAFLD involve hepatic insulin res...
Blood phytosterols in relation to cardiovascular diseases and mediating effects of blood lipids and hematological traits: a Mendelian randomization analysis [0.03%]
血植物甾醇与心血管疾病的相关性及其介导效应：孟德尔随机化分析
Yimin Zhao,Zhenhuang Zhuang,Yueying Li et al.
Yimin Zhao et al.
Background: Short-term clinical trials have shown the cholesterol-lowering potentials of phytosterols, but their impacts on cardiovascular disease (CVD) remain controversial. This study used the Mendelian randomization (M...
Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction [0.03%]
酮酯补充抑制心脏炎症并改善急性心肌梗死猪模型的心脏能量代谢
Salva R Yurista,Robert A Eder,Aidan Welsh et al.
Salva R Yurista et al.
Background: Myocardial infarction (MI) is a major risk factor for the development of heart failure with reduce ejection fraction (HFrEF). While previous studies have focused on HFrEF, the cardiovascular effects of ketone ...
Sarcopenic obesity in free-living older adults detected by the ESPEN-EASO consensus diagnostic algorithm: Validation in an Italian cohort and predictive value of insulin resistance and altered plasma ghrelin profile [0.03%]
根据ESPEN-EASO共识诊断算法检测到的老年人 sarcopenic obesity：意大利人群中的验证和胰岛素抵抗及血浆 ghrelin 水平异常的预测价值
Gianluca Gortan Cappellari,Annamaria Semolic,Michela Zanetti et al.
Gianluca Gortan Cappellari et al.
Aging and obesity are synergistic sarcopenia risk factors (RF). Their association in sarcopenic obesity (SO) enhances morbidity and mortality, but consensus on SO diagnostic criteria is limited. ESPEN and EASO issued a consensus algorithm f...
Energy metabolism in platelets fuels thrombus formation: Halting the thrombosis engine with small-molecule modulators of platelet metabolism [0.03%]
血小板能量代谢驱动血栓形成：用小分子调节剂关闭血小板代谢引擎以阻止血栓形成
Paresh P Kulkarni,Mohammad Ekhlak,Debabrata Dash
Paresh P Kulkarni
Platelets are circulating cells central to haemostasis that follows vessel injury, as well as thrombosis that ensues as a consequence of pathological stasis or plaque rupture. Platelet responses to various stimuli that mediate these process...