Yves Rolland,Cedric Dray,Bruno Vellas et al.
Yves Rolland et al.
Sarcopenia, defined as the loss of muscle mass and function, is a widely prevalent and severe condition in older adults. Since 2016, it is recognized as a disease. Strength exercise training and nutritional support are the frontline treatme...
Evelien Gielen,Jolan Dupont,Marian Dejaeger et al.
Evelien Gielen et al.
Muscles and bones are intricately connected tissues displaying marked co-variation during development, growth, aging, and in many diseases. While the diagnosis and treatment of osteoporosis are well established in clinical practice, sarcope...
HSD17B6 delays type 2 diabetes development via inhibiting SREBP activation [0.03%]
HSD17B6通过抑制SREBP激活来延缓二型糖尿病的发展
Fengxiang Wei,Yan Gu,Lizhi He et al.
Fengxiang Wei et al.
Background: The SREBP/SCAP/INSIG complex plays an essential role in SREBP activation and de novo lipogenesis. Whether the activation process is affected by hydroxysteroid 17-beta dehydrogenase 6 (HSD17B6) remains unknown....
Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD [0.03%]
富马酸/富马酸受体轴对非酒精性脂肪肝病损伤肝细胞的保护作用
Anna Marsal-Beltran,Adrià Rodríguez-Castellano,Brenno Astiarraga et al.
Anna Marsal-Beltran et al.
Objective: Succinate and succinate receptor 1 (SUCNR1) are linked to fibrotic remodeling in models of non-alcoholic fatty liver disease (NAFLD), but whether they have roles beyond the activation of hepatic stellate cells ...
OCTN2 enhances PGC-1α-mediated fatty acid oxidation and OXPHOS to support stemness in hepatocellular carcinoma [0.03%]
OCTN2通过增强PGC-1α介导的脂肪酸氧化和OXPHOS来支持肝细胞癌干细胞特性
Tao Yang,Ning Liang,Jiahao Zhang et al.
Tao Yang et al.
Background: The Metabolic reprogramming of tumor cells plays a vital role in the progression of hepatocellular carcinoma. Organic cation/carnitine transporter 2 (OCTN2), a sodium-ion dependent carnitine transporter and a ...
Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study [0.03%]
基于基因代理的纤维细胞生长因子21的肾保护作用：孟德尔随机化、蛋白质组范围和代谢组范围的关联研究
Alice Giontella,Loukas Zagkos,Milan Geybels et al.
Alice Giontella et al.
Background: Fibroblast growth factor 21 (FGF21) has demonstrated efficacy for reducing liver fat and reversing non-alcoholic steatohepatitis in phase 2 clinical trials. It is also postulated to have anti-fibrotic effects ...
The key role of inflammation in the pathogenesis and management of obesity and CVD [0.03%]
炎症在肥胖和心血管疾病发病机制及治疗中的关键作用
Chrysoula Boutari,Michael A Hill,Claudio Procaccini et al.
Chrysoula Boutari et al.
Mitochondrial quality control in cardiac fibrosis: Epigenetic mechanisms and therapeutic strategies [0.03%]
心脏纤维化中的线粒体质量控制：表观遗传机制和治疗策略
Li-Chan Lin,Bin Tu,Kai Song et al.
Li-Chan Lin et al.
Cardiac fibrosis (CF) is considered an ultimate common pathway of a wide variety of heart diseases in response to diverse pathological and pathophysiological stimuli. Mitochondria are characterized as isolated organelles with a double-membr...
High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity [0.03%]
肥胖脂肪细胞内的内源性高水平通过COPII囊泡向自噬体供应介导自噬流受损并促进系统性胰岛素抵抗
Jiyoung Oh,Chanho Park,Sahee Kim et al.
Jiyoung Oh et al.
Background and aims: Extracellular matrix (ECM) homeostasis plays a crucial role in metabolic plasticity and endocrine function of adipose tissue. High levels of intracellular endotrophin, a cleavage peptide of type VI co...
Marina Chaves de Oliveira,Ana Letícia Malheiros Silveira,Amanda Carla Clemente de Oliveira et al.
Marina Chaves de Oliveira et al.
Background: Eosinophils are generally related to helminth infections or allergies. Their association with metabolic alterations and adipose tissue (AT) remodeling has been demonstrated mainly in animal models of obesity. ...