SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis [0.03%]
钠葡萄糖协同转运蛋白2抑制剂恩格列净下调miRNA-34a-5p，靶向GREM2以抑制非酒精性脂肪性肝病相关肝星状细胞活化和纤维化
Yunfeng Shen,Lidan Cheng,Minxuan Xu et al.
Yunfeng Shen et al.
Background and rationale: Activation of hepatic stellate cells (HSCs), the central event of fibrosis, indicates the severe stage of non-alcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) participate in this process...
Alcoholic Setdb1 suppression promotes hepatosteatosis in mice by strengthening Plin2 [0.03%]
酒精介导的Setdb1抑制通过增强Plin2促进小鼠肝脂变性
Yi Zhang,Yanhui Li,Yang Liu et al.
Yi Zhang et al.
Background and aims: Hepatosteatosis is one of the early features of alcoholic liver disease (ALD) and pharmaceutical or genetic interfering of the development of hepatosteatosis will efficiently alleviate the progression...
Effect of bariatric surgery on cardio-psycho-metabolic outcomes in severe obesity: A randomized controlled trial [0.03%]
代谢手术对重度肥胖患者心血管心理代谢结局影响的随机对照试验
Ann-Cathrin Koschker,Bodo Warrings,Caroline Morbach et al.
Ann-Cathrin Koschker et al.
Objective: Randomized evidence comparing the cardiovascular effects of surgical and conservative weight management is lacking. Patients & methods: ...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2023 Oct:147:155655. DOI:10.1016/j.metabol.2023.155655 2023
The N-degron pathway mediates lipophagy: The chemical modulation of lipophagy in obesity and NAFLD [0.03%]
N-末端降解子途径介导脂噬作用：肥胖和非酒精性脂肪肝病中化学调节脂噬作用的方法
Eui Jung Jung,Ki Woon Sung,Tae Hyun Bae et al.
Eui Jung Jung et al.
Background and aims: Central to the pathogenesis of nonalcoholic fatty liver disease (NAFLD) is the accumulation of lipids in the liver and various fat tissues. We aimed to elucidate the mechanisms by which lipid droplets...
A healthy lifestyle, Life's Essential 8 scores and new-onset severe NAFLD: A prospective analysis in UK Biobank [0.03%]
健康的生活方式、生命八大指标评分与新发严重非酒精性脂肪肝：英国生物样本库的前瞻性分析
Panpan He,Yanjun Zhang,Ziliang Ye et al.
Panpan He et al.
Background: The association of a healthy lifestyle and the American Heart Association (AHA) Life's Essential 8 (LE8) score with the risk of new-onset nonalcoholic fatty liver disease (NAFLD) remains uncertain. We aimed to...
Blocking IL-6 signaling improves glucose tolerance via SLC39A5-mediated suppression of glucagon secretion [0.03%]
通过介导胰高血糖素分泌抑制改善葡萄糖耐量(IL-6信号传导阻断)
Wenli Chen,Weiyi Cui,Jianhong Wu et al.
Wenli Chen et al.
Background and aims: Hyperinsulinemia, hyperglucagonemia, and low-grade inflammation are frequently presented in obesity and type 2 diabetes (T2D). The pathogenic regulation between hyperinsulinemia/insulin resistance (IR...
Nonalcoholic fatty liver disease (NAFLD) and associated mortality in individuals with type 2 diabetes, pre-diabetes, metabolically unhealthy, and metabolically healthy individuals in the United States [0.03%]
美国2型糖尿病、前期和代谢健康与不健康个体中的非酒精性脂肪肝疾病(NALFD)及其相关死亡率
Pegah Golabi,James M Paik,Ameeta Kumar et al.
Pegah Golabi et al.
Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) is high among subjects with type 2 diabetes (T2D). However, the prevalence and outcomes of NAFLD among individuals with pre-diabetes (PreD) and metabo...
Christopher L Axelrod,Wagner S Dantas,John P Kirwan
Christopher L Axelrod
Sarcopenic obesity, or the loss of muscle mass and function associated with excess adiposity, is a largely untreatable medical condition associated with diminished quality of life and increased risk of mortality. To date, it remains somewha...
Continuous glucose monitoring in a healthy population: understanding the post-prandial glycemic response in individuals without diabetes mellitus [0.03%]
连续葡萄糖监测在健康人群中的应用：无糖尿病患者餐后血糖变化的个体间差异性分析
Paul R E Jarvis,Jessica L Cardin,Pamela M Nisevich-Bede et al.
Paul R E Jarvis et al.
Continuous glucose monitoring has become a common adjunct in the management of Diabetes Mellitus. However, there has been a recent trend among individuals without diabetes using these devices as a means of monitoring their health. The incre...
Riccardo Calvani,Anna Picca,Hélio José Coelho-Júnior et al.
Riccardo Calvani et al.
Sarcopenia is a geriatric condition characterized by a progressive loss of skeletal muscle mass and strength, with an increased risk of adverse health outcomes (e.g., falls, disability, institutionalization, reduced quality of life, mortali...