Perinatal metabolic inflammation in the hypothalamus impairs the development of homeostatic feeding circuitry [0.03%]
孕期下丘脑代谢性炎症损害稳态摄食环路的发育
Rahim Ullah,Yi Shen,Yu-Dong Zhou et al.
Rahim Ullah et al.
Over the past few decades, there has been a global increase in childhood obesity. This rise in childhood obesity contributes to the susceptibility of impaired metabolism during both childhood and adulthood. The hypothalamus, specifically th...
Liver biopsy-based validation, confirmation and comparison of the diagnostic performance of established and novel non-invasive steatotic liver disease indexes: Results from a large multi-center study [0.03%]
基于肝穿刺的大规模多中心研究验证、确认并比较既往和新型非侵入性诊断脂肪肝病指标的效能
Matina Kouvari,Laura Valenzuela-Vallejo,Valentina Guatibonza-Garcia et al.
Matina Kouvari et al.
Background: Non-invasive tools (NIT) for metabolic-dysfunction associated liver disease (MASLD) screening or diagnosis need to be thoroughly validated using liver biopsies. ...
Protein kinases: The key contributors in pathogenesis and treatment of nonalcoholic fatty liver disease-derived hepatocellular carcinoma [0.03%]
蛋白激酶在非酒精性脂肪肝病源肝细胞癌发生及治疗中的关键作用
Rong Liu,Ming-Ping Qian,Ying-Yu Cui
Rong Liu
Protein kinases (PKs), one of the largest protein families, can be further divided into different groups based on their substrate or structure and function. PKs are important signaling messengers in numerous life activities, including cell ...
Transcription factor EB: A potential integrated network regulator in metabolic-associated cardiac injury [0.03%]
转录因子EB：代谢相关心脏损伤中潜在的整合调控网络中心
Weixing Wen,Haoxiao Zheng,Weiwen Li et al.
Weixing Wen et al.
With the worldwide pandemic of metabolic diseases, such as obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD), cardiometabolic disease (CMD) has become a significant cause of death in humans. However, the pathophysiology of me...
From non-alcoholic fatty liver disease (NAFLD) to steatotic liver disease (SLD): an ongoing journey towards refining the terminology for this prevalent metabolic condition and unmet clinical need [0.03%]
从非酒精性脂肪肝疾病（NAFLD）到肝脂变性疾病(SLD): 一种不断发展的流行代谢疾病的术语修正和未被满足的临床需求之旅
Michail Kokkorakis,Chrysoula Boutari,Niki Katsiki et al.
Michail Kokkorakis et al.
Uroguanylin prevents hepatic steatosis, mitochondrial dysfunction and fibrosis in obesity-associated NAFLD [0.03%]
尿苷昔核甘防止肥胖相关性非酒精性脂肪肝病的肝脏脂变、线粒体功能障碍和纤维化现象
Eva M Fernández-Sáez,Maite Losarcos,Sara Becerril et al.
Eva M Fernández-Sáez et al.
Background: The biological mediators supporting the resolution of liver steatosis, inflammation and fibrosis after bariatric surgery in patients with obesity and NAFLD remain unclear. We sought to analyze whether uroguany...
Hepatocyte-secreted FAM3D ameliorates hepatic steatosis by activating FPR1-hnRNP U-GR-SCAD pathway to enhance lipid oxidation [0.03%]
肝细胞分泌的FAM3D通过激活FPR1-hnRNP U-GR-SCAD通路增强脂质氧化来改善肝脏脂肪变性
Yuntao Hu,Jing Li,Xin Li et al.
Yuntao Hu et al.
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide; however, the underlying mechanisms remain poorly understood. FAM3D is a member of the FAM3 family; however, its role in hepatic glycolipid metaboli...
miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis [0.03%]
miR-32-5p通过诱导从头脂质合成诱导肝脂肪变性和高脂血症
Ya-Di Wang,Liang-Liang Wu,Yun-Ni Mai et al.
Ya-Di Wang et al.
Background and objectives: MicroRNA-dependent regulation of hepatic lipid metabolism has been recognized recently as a key pathological mechanism contributing to the development of NAFLD. However, whether miR-32-5p (miR-3...
Ferroptosis, a new pathogenetic mechanism in cardiometabolic diseases and cancer: Is there a role for statin therapy? [0.03%]
铁沉积诱发的心肌细胞 ferroptosis 与心血管代谢性疾病和癌症：他汀治疗的作用机制？
Amirhossein Sahebkar,Zahra Foroutan,Niki Katsiki et al.
Amirhossein Sahebkar et al.
One of the newly recognized types of cell death is ferroptosis which is related to the accumulation of iron and lipid-reactive oxygen species. Ferroptosis is considered a programmed cell death with a different mechanism from apoptosis, necr...
PRDM16 exerts critical role in myocardial metabolism and energetics in type 2 diabetes induced cardiomyopathy [0.03%]
PRDM16在2型糖尿病诱导的心肌病中对心肌代谢和能量稳态发挥关键作用
Tongtong Hu,Qingqing Wu,Qi Yao et al.
Tongtong Hu et al.
Background: The prevalence of type 2 diabetes mellitus (T2DM) has increased over the past decades. Diabetic cardiomyopathy (DCM) is the leading cause of death in T2DM patients, however, the mechanism underlying DCM remain...