Postpartum defects in inflammatory response after gestational diabetes precede progression to type 2 diabetes: a nested case-control study within the SWIFT study [0.03%]
妊娠糖尿病产后炎症反应缺陷先于2型糖尿病的发展：SWIFT研究中的病例对照研究
Julie A D Van,Yihan Luo,Jayne S Danska et al.
Julie A D Van et al.
Background: Gestational diabetes (GDM) is a distinctive form of diabetes that first presents in pregnancy. While most women return to normoglycemia after delivery, they are nearly ten times more likely to develop type 2 d...
Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study [0.03%]
多中心观察性研究中经活检证实的脂肪肝病和脂肪性肝炎患者的循环激素水平
Laura Valenzuela-Vallejo,Pavlina Chrysafi,Matina Kouvari et al.
Laura Valenzuela-Vallejo et al.
Background: The role of metabolic/inflammatory hormonal systems in metabolic dysfunction associated steatotic liver disease (MASLD) remains to be fully elucidated. ...
Observational Study
Metabolism: clinical and experimental. 2023 Nov:148:155694. DOI:10.1016/j.metabol.2023.155694 2023
The global burden of metabolic disease in children and adolescents: Data from the Global Burden of Disease 2000-2019 [0.03%]
2000年至2019年全球儿童和青少年代谢性疾病疾病负担：来自全球疾病负担研究的数据
Jieyu Peng,Muhan Lü,Ping Wang et al.
Jieyu Peng et al.
Menghao Huang,Yang Zhang,Jimin Park et al.
Menghao Huang et al.
Background & aims: Autophagy-related 14 (ATG14) is a key regulator of autophagy. ATG14 is also localized to lipid droplet; however, the function of ATG14 on lipid droplet remains unclear. In this study, we aimed to elucid...
Khaled Alabduljabbar,Carel W le Roux
Khaled Alabduljabbar
Diabetes is a chronic disease that affects a vast number of individuals globally, and without optimal treatment, can lead to significant health complications. Moreover, obesity is another chronic disease with several complications, which in...
Hepatocyte TIPE2 is a fasting-induced Raf-1 inactivator that drives hepatic gluconeogenesis to maintain glucose homeostasis [0.03%]
肝细胞TIPE2是葡萄糖诱导的Raf-1失活因子，可驱动肝脏糖异生以维持血糖平衡
Yan Tao,Jingyuan Zhao,Jilong Yin et al.
Yan Tao et al.
Background: The liver regulates metabolic balance during fasting-feeding cycle. Hepatic adaptation to fasting is precisely modulated on multiple levels. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is a negat...
Milestones in the journey towards addressing obesity; Past trials and triumphs, recent breakthroughs, and an exciting future in the era of emerging effective medical therapies and integration of effective medical therapies with metabolic surgery [0.03%]
肥胖症防治之路的里程碑；过去的挫折与成功，近期突破以及在有效医疗手段与代谢手术整合新时代下的光明未来
Michail Kokkorakis,Angeliki Katsarou,Niki Katsiki et al.
Michail Kokkorakis et al.
The 21st century is characterized by an increasing incidence and prevalence of obesity and the burden of its associated comorbidities, especially cardiometabolic diseases, which are reaching pandemic proportions. In the late '90s, the "blac...
Additive impact of diabetes and sarcopenia on all-cause and cardiovascular mortality: A longitudinal nationwide population-based study [0.03%]
糖尿病和肌少症对全因及心血管死亡的联合作用：一项纵向全国队列研究
Eyun Song,Soon Young Hwang,Min Jeong Park et al.
Eyun Song et al.
Objective: Diabetes mellitus (DM) and sarcopenia (SP) are growing public health concerns in an aging society, which share common pathophysiological mechanisms and are associated with serious health consequences. We invest...
Olfactomedin 4 deletion exacerbates nonalcoholic fatty liver disease through P62-dependent mitophagy in mice [0.03%]
小鼠ORMD4缺失通过P62依赖的线粒体自噬加重非酒精性脂肪肝病
Shenghui Chen,Xinyu Wang,Zhening Liu et al.
Shenghui Chen et al.
Background & aims: Olfactomedin 4 (OLFM4) is a glycoprotein that is related to obesity and insulin resistance. This study aims to investigate the role and mechanisms of OLFM4 in nonalcoholic fatty liver disease (NAFLD). ...
Stergios A Polyzos,Ilias D Vachliotis,Christos S Mantzoros
Stergios A Polyzos
Nonalcoholic fatty liver disease (NAFLD), sarcopenia and sarcopenic obesity (SO) are highly prevalent conditions that may coexist, especially in the aging population, without any approved pharmacologic treatment for all of them. There are m...