Sarcopenia: still in relative definition-penia and severe treatment-penia [0.03%]
sarcopenia：仍处于相对定义过剩和严重治疗缺乏的状态
Stergios A Polyzos,Christos S Mantzoros
Stergios A Polyzos
Epicardial adipose tissue measured from analysis of adipose tissue area using chest CT imaging is the best potential predictor of COVID-19 severity [0.03%]
胸部CT影像分析法测量的冠状动脉脂肪组织面积是预测新冠肺炎重症的最佳潜在指标
Takahiro Fukushima,Tomoki Maetani,Shotaro Chubachi et al.
Takahiro Fukushima et al.
Background: Computed tomography (CT) imaging is widely used for diagnosing and determining the severity of coronavirus disease 2019 (COVID-19). Chest CT imaging can be used to calculate the epicardial adipose tissue (EAT)...
Adiponectin stimulates Sca1+CD34--adipocyte precursor cells associated with hyperplastic expansion and beiging of brown and white adipose tissue [0.03%]
脂联素刺激Sca1+CD34-脂肪前体细胞与褐色和白色脂肪组织的增生性扩张和褐变有关
Marco Bauzá-Thorbrügge,Milica Vujičić,Belén Chanclón et al.
Marco Bauzá-Thorbrügge et al.
Background: The adipocyte hormone adiponectin improves insulin sensitivity and there is an inverse correlation between adiponectin levels and type-2 diabetes risk. Previous research shows that adiponectin remodels the adi...
Glucocorticoids and intrauterine programming of nonalcoholic fatty liver disease [0.03%]
糖皮质激素与宫内非酒精性脂肪肝病的编程效应
Ze Chen,Li-Ping Xia,Lang Shen et al.
Ze Chen et al.
Accumulating epidemiological and experimental evidence indicates that nonalcoholic fatty liver disease (NAFLD) has an intrauterine origin. Fetuses exposed to adverse prenatal environments (e.g., maternal malnutrition and xenobiotic exposure...
Upper small intestine microbiome in obesity and related metabolic disorders: A new field of investigation [0.03%]
肥胖及相关代谢障碍中上小肠菌群的研究：一个全新的研究领域
Emilie Steinbach,Davide Masi,Agnès Ribeiro et al.
Emilie Steinbach et al.
The study of the gut microbiome holds great promise for understanding and treating metabolic diseases, as its functions and derived metabolites can influence the metabolic status of the host. While research on the fecal microbiome has provi...
Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors [0.03%]
肌少症的发病机制：遗传因素及其与环境因素的相互作用
Muhammad Arif Aslam,Eun Bi Ma,Joo Young Huh
Muhammad Arif Aslam
Sarcopenia is a geriatric disorder characterized by a progressive decline in muscle mass and function. This disorder has been associated with a range of adverse health outcomes, including fractures, functional deterioration, and increased m...
Brown adipose tissue-derived metabolites and their role in regulating metabolism [0.03%]
棕色脂肪组织衍生代谢产物及其在调节代谢中的作用
Khanyisani Ziqubu,Phiwayinkosi V Dludla,Sihle E Mabhida et al.
Khanyisani Ziqubu et al.
The discovery and rejuvenation of metabolically active brown adipose tissue (BAT) in adult humans have offered a new approach to treat obesity and metabolic diseases. Beyond its accomplished role in adaptive thermogenesis, BAT secretes sign...
Angiotensin II type 1 receptor-associated protein in immune cells: a possible key factor in the pathogenesis of visceral obesity [0.03%]
免疫细胞中的血管紧张素Ⅱ型受体相关蛋白在腹型肥胖发病机制中的作用
Shunichiro Tsukamoto,Toru Suzuki,Hiromichi Wakui et al.
Shunichiro Tsukamoto et al.
Background and aim: Dysregulation of angiotensin II type 1 receptor-associated protein (ATRAP) expression in cardiovascular, kidney, and adipose tissues is involved in the pathology of hypertension, cardiac hypertrophy, a...
Safety and efficacy of the new, oral, small-molecule, GLP-1 receptor agonists orforglipron and danuglipron for the treatment of type 2 diabetes and obesity: systematic review and meta-analysis of randomized controlled trials [0.03%]
新型口服GLP-1受体激动剂orforglipron和danuglipron治疗2型糖尿病及肥胖安全性和有效性的系统评价和.meta.分析：随机对照试验
Paschalis Karakasis,Dimitrios Patoulias,Konstantinos Pamporis et al.
Paschalis Karakasis et al.
Aims: The present systematic review aimed to synthesize available data from recently published randomized trials (RCTs) investigating the efficacy and safety of the novel, orally administered, small-molecule glucagon-like...
Dopamine in the nucleus accumbens shell controls systemic glucose metabolism via the lateral hypothalamus and hepatic vagal innervation in rodents [0.03%]
小鼠纹状体多巴胺通过侧脑室和肝迷走神经支配控制全身葡萄糖代谢
Charlene Diepenbroek,Merel Rijnsburger,Astrid A S van Irsen et al.
Charlene Diepenbroek et al.
Background: Growing evidence demonstrates the role of the striatal dopamine system in the regulation of glucose metabolism. Treatment with dopamine antagonists is associated with insulin resistance and hyperglycemia, whil...