Addressing uncertainty about the role of structured lifestyle modification for metabolic surgery patients [0.03%]
代谢手术患者的结构化生活方式改变的作用不确定性及其应对措施
Enda Murphy,Francis M Finucane
Enda Murphy
There is good evidence that structured lifestyle modification programmes improve health in patients with metabolic and cardiovascular disorders, but there is no specific evidence that they improve outcomes in patients undergoing metabolic o...
Towards personalized genome-scale modeling of inborn errors of metabolism for systems medicine applications [0.03%]
针对代谢缺陷的个性化基因组建模用于系统医学研究
Almut Heinken,Sandra El Kouche,Rosa-Maria Guéant-Rodriguez et al.
Almut Heinken et al.
Inborn errors of metabolism (IEMs) are a group of more than 1000 inherited diseases that are individually rare but have a cumulative global prevalence of 50 per 100,000 births. Recently, it has been recognized that like common diseases, pat...
PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease [0.03%]
PCSK7：一种新的载脂蛋白B调节因子及潜在的非酒精性脂肪肝病治疗靶点
Vatsal Sachan,Maïlys Le Dévéhat,Anna Roubtsova et al.
Vatsal Sachan et al.
Background: Epidemiological evidence links the proprotein convertase subtilisin/kexin 7 (PCSK7) to triglyceride (TG) metabolism. We associated the known PCSK7 gain-of-function non-coding SNP rs236918 with higher levels of...
CCDC92 deficiency ameliorates podocyte lipotoxicity in diabetic kidney disease [0.03%]
CCDC92缺乏可缓解糖尿病肾脏疾病的 podocytes 脂毒性
Fuwen Zuo,Youzhao Wang,Xinlei Xu et al.
Fuwen Zuo et al.
Background and aims: Podocyte injury is considered as the most important early event contributing to diabetic kidney disease (DKD). Recent findings provide new insights into the roles of lipids and lipid-modulating protei...
Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4 [0.03%]
KDM2B在lncPRC1.1背景下与MYC和ATF4协同调节氨基酸代谢的转录调控
Evangelia Chavdoula,Vollter Anastas,Alessandro La Ferlita et al.
Evangelia Chavdoula et al.
Introduction: KDM2B encodes a JmjC domain-containing histone lysine demethylase, which functions as an oncogene in several types of tumors, including TNBC. This study was initiated to address the cancer relevance of the r...
Chrysoula Boutari,Michail Kokkorakis,Konstantinos Stefanakis et al.
Chrysoula Boutari et al.
The ubiquitin-like modifier FAT10 is induced in MASLD and impairs the lipid-regulatory activity of PPARα [0.03%]
脂肪样变诱导的泛素化修饰因子FAT10通过抑制PPARα脂质调节活性促进NASH发生发展
Ludivine Clavreul,Lucie Bernard,Alexia K Cotte et al.
Ludivine Clavreul et al.
Background and aims: Peroxisome Proliferator-Activated Receptor α (PPARα) is a key regulator of hepatic lipid metabolism and therefore a promising therapeutic target against Metabolic-dysfunction Associated Steatotic Li...
Joongmin Kim,Hyeongsoo Kim,Sang Hyun Park et al.
Joongmin Kim et al.
Background: As intermediate cardiovascular risk group accounts for a large part of the total population, determining appropriate cholesterol target in this population is critical. Herein, we investigated the optimal low-d...
Observational Study
Metabolism: clinical and experimental. 2024 Jan:150:155723. DOI:10.1016/j.metabol.2023.155723 2024
Zilv Luo,Zhaowei Chen,Jijia Hu et al.
Zilv Luo et al.
Podocytes are critical for maintaining permselectivity of the glomerular filtration barrier, and podocyte injury is a major cause of proteinuria in various primary and secondary glomerulopathies. Lipid dysmetabolism and inflammatory activat...
Can liquid biopsies for MASH help increase the penetration of metabolic surgery? A narrative review [0.03%]
液体活检(MASH)能提高代谢手术的渗透率吗？一篇叙述性评论文章
Lidia Castagneto-Gissey,Stefan R Bornstein,Geltrude Mingrone
Lidia Castagneto-Gissey
This narrative review highlights current evidence on non-invasive tests to predict the presence or absence as well as the severity of metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis. Metabolic dysfunction-associat...