Markers of adipose tissue fibrogenesis associate with clinically significant liver fibrosis and are unchanged by synbiotic treatment in patients with NAFLD [0.03%]
与非酒精性脂肪肝患者显著的临床肝纤维化相关的脂毒性标志物及合生元对此无治疗作用
Josh Bilson,Carolina J Oquendo,James Read et al.
Josh Bilson et al.
Background and aims: Subcutaneous adipose tissue (SAT) dysfunction contributes to NAFLD pathogenesis and may be influenced by the gut microbiota. Whether transcript profiles of SAT are associated with liver fibrosis and a...
Chemokine receptor CCR1 regulates macrophage activation through mTORC1 signaling in nonalcoholic steatohepatitis [0.03%]
趋化因子受体CCR1通过mTORC1信号调节非酒精性 steatohepatitis中的巨噬细胞活化
Haoran Li,Tongtong Pan,Lingjia Gao et al.
Haoran Li et al.
Background and aims: Chemokine (CC motif) receptor 1 (CCR1) promotes liver fibrosis in mice. However, its effects on nonalcoholic steatohepatitis (NASH) remain unclear. Therefore, the present study aimed to investigate th...
The role of ROS in tumor infiltrating immune cells and cancer immunotherapy [0.03%]
活性氧在肿瘤浸润性免疫细胞和癌症免疫治疗中的作用
Rushil Shah,Betul Ibis,Monisha Kashyap et al.
Rushil Shah et al.
Reactive oxygen species (ROS) are a group of short-lived highly reactive molecules formed intracellularly from molecular oxygen. ROS can alter biochemical, transcriptional, and epigenetic programs and have an indispensable role in cellular ...
Suhaniya N S Samarasinghe,Casper Woods,Alexander Dimitri Miras
Suhaniya N S Samarasinghe
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in premenopausal women and is a common cause of anovulatory subfertility. Although obesity does not form part of the diagnostic criteria, it affects a significant propo...
Rising global burden of cancer attributable to high BMI from 2010 to 2019 [0.03%]
2010年至2019年全球可归因于高体质指数的癌症负担不断加重
Darren Jun Hao Tan,Cheng Han Ng,Mark Muthiah et al.
Darren Jun Hao Tan et al.
Background: High body mass index (BMI) is a major risk factor for cancer development, but its impact on the global burden of cancer remains unclear. Metho...
Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss [0.03%]
TM4SF19缺乏抑制破骨细胞多核化和预防骨丢失
Sujin Park,Jin Sun Heo,Seiya Mizuno et al.
Sujin Park et al.
Background: Multinucleation is a hallmark of osteoclast formation and has a unique ability to resorb bone matrix. During osteoclast differentiation, the cytoskeleton reorganization results in the generation of actin belts...
Zhigang Ke,Zongshi Lu,Qing Li et al.
Zhigang Ke et al.
The gut has been increasingly recognized in recent years as a pivotal organ in the maintenance of glucose homeostasis. Specifically, the profound and enduring improvement in glucose metabolism achieved through metabolic surgery to modify th...
Plasma metabolite predictors of metabolic syndrome incidence and reversion [0.03%]
预测代谢综合征发生和逆转的血浆代谢标志物
Zhila Semnani-Azad,Estefanía Toledo,Nancy Babio et al.
Zhila Semnani-Azad et al.
Background: Metabolic Syndrome (MetS) is a progressive pathophysiological state defined by a cluster of cardiometabolic traits. However, little is known about metabolites that may be predictors of MetS incidence or revers...
Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond [0.03%]
肥胖药物治疗的进展；从代谢手术中吸取经验并展望未来
Dimitrios Tsilingiris,Alexander Kokkinos
Dimitrios Tsilingiris
Currently, metabolic surgery (MS) constitutes the most effective means for durable weight loss of clinically meaningful magnitude, type 2 diabetes remission and resolution of non-alcoholic steatohepatitis, as well as other obesity-related c...
Gut-derived ammonia contributes to alcohol-related fatty liver development via facilitating ethanol metabolism and provoking ATF4-dependent de novo lipogenesis activation [0.03%]
肠道来源的氨通过促进酒精代谢和诱发ATF4依赖性的从头脂质生成激活而参与酒精相关性脂肪肝的发病机制
Qing Song,Chueh-Lung Hwang,Yanhui Li et al.
Qing Song et al.
Background & aims: Dysbiosis contributes to alcohol-associated liver disease (ALD); however, the precise mechanisms remain elusive. Given the critical role of the gut microbiota in ammonia production, we herein aim to inv...