Sex differences in cardiovascular-kidney-metabolic syndrome and new onset cardiovascular outcomes [0.03%]
心血管-肾脏-代谢综合征的性别差异及新发的心血管结局事件
Lin Liu,An Ping Cai,Kevin Chun Hei Wu et al.
Lin Liu et al.
Background: Cardiovascular-Kidney-Metabolic (CKM) syndrome integrates metabolic risk factors, chronic kidney disease (CKD), and cardiovascular dysfunction, and is closely linked to cardiovascular disease (CVD) risk. We ai...
From mechanism to clinic: A call for actionable strategies to optimize finerenone and SGLT2i complementary therapy in T2DM-related CKD [0.03%]
从机制到临床：呼吁制定切实可行的策略以优化非奈利酮与SGLT2抑制剂联合治疗2型糖尿病相关肾病
Yangqing Cui,Junyuan Zhu,Yang Liu
Yangqing Cui
Association of daytime circadian-aligned activity with glycemic control in type 2 diabetes: Insights from continuous glucose monitoring and wearable data [0.03%]
circadian同步的白天活动与2型糖尿病患者血糖控制的关系：来自连续葡萄糖监测和可穿戴设备数据的启示
Da Young Lee,Jung-Been Lee,Inha Jung et al.
Da Young Lee et al.
Background: Prior research on circadian rhythms have primarily focused on the risk of diabetes, with limited evidence on their impact in glycemic control among individuals with type 2 diabetes. This study investigated the...
Targeting Gβγ subunits in hypothalamic AgRP neurons to treat obesity [0.03%]
靶向作用于下丘脑AgRP神经元的G蛋白γ亚基以治疗肥胖症
Ye Xuan,Xiaoyue Xiong,Xinyu Wang et al.
Ye Xuan et al.
G protein-coupled receptors (GPCRs) in the central nervous system, particularly in the hypothalamus, are promising therapeutic targets for the treatment of obesity and related metabolic disorders. However, the development of anti-obesity dr...
Corrigendum to "Current and investigational medications for the treatment of sarcopenia" [Metabolism 2023;149:155597] [0.03%]
关于“用于治疗肌少症的当前和 investigational 药物调查”一文的勘误(2023年代谢第149卷155597期)
Y Rolland,C Dray,B Vellas et al.
Y Rolland et al.
Folic acid mitigation of alcohol-induced sarcopenia via gut-muscle axis modulation [0.03%]
叶酸通过调节肠肌轴缓解酒精引起的肌肉减少症
Nan Zhang,Jing Shi,Huaqi Zhang et al.
Nan Zhang et al.
Background: Alcohol-related muscle dysfunction is highly prevalent and substantially impairs the quality of life in individuals with alcohol use disorders. Chronic alcohol consumption-induced folic acid (FA) deficiency, p...
The early metabolic cardiac targets of empagliflozin during the development of heart failure, independent of SGLT2 inhibition [0.03%]
恩格列净在心力衰竭发病过程中的早期代谢性心脏靶点及其独立于SGLT2抑制的作用
Sha Chen,Xin Hu,Qian Wang et al.
Sha Chen et al.
Background & purpose: Cardiac metabolic changes are known early drivers of heart failure (HF). Recent preclinical research showed that protection against HF by sodium glucose transporter 2 inhibitors (SGLT2i) is independe...
Mini-review. Vitamin D for the prevention of type 2 diabetes: Evidence and implications [0.03%]
维生素D与二型糖尿病预防：证据及其影响的简评
Karin Amrein,Sun H Kim,Helmut Brath et al.
Karin Amrein et al.
Prediabetes is common worldwide and offers a critical opportunity for interventions to prevent type 2 diabetes. Vitamin D has biologically plausible effects on beta cell function, insulin sensitivity, and the immune system, and observationa...
The multifaceted role of GLP-1 in metabolic disorders, chronic inflammation, and aging: Mechanisms and therapeutic potential [0.03%]
GLP-1在代谢紊乱、慢性炎症和衰老中的多面作用：机制与治疗潜力
Mo Li,Shenghao Xu,Hanqing Cai et al.
Mo Li et al.
Glucagon-like peptide-1 (GLP-1), an incretin secreted by intestinal L-cells in response to nutrients, regulates glucose homeostasis by enhancing insulin secretion, suppressing glucagon release, delaying gastric emptying, and reducing appeti...
Serum Response Factor (SRF) promotes actin cytoskeletal organization in adipocytes to support adaptive hypertrophic expansion and tissue remodeling during obesity in mice [0.03%]
血清应答因子(SRF)促进小鼠肥胖期间脂肪细胞适应性肥大扩张和组织重塑过程中的肌动蛋白细胞质骨架的组织化
Jisun So,Jamie Wann,Kyungchan Kim et al.
Jisun So et al.
Background: Adipocyte hypertrophy, the unique capacity of adipocytes to enlarge in response to energy surplus, is a crucial determinant of metabolic health during obesity. Nonetheless, the molecular mechanisms governing t...