Best practice recommendations for the diagnosis and management of hypoparathyroidism [0.03%]
低血钙症的诊断和治疗建议
Aliya A Khan,Dalal S Ali,John P Bilezikian et al.
Aliya A Khan et al.
Background: Hypoparathyroidism (HypoPT) is characterized by low serum calcium due to insufficient parathyroid hormone (PTH). This manuscript builds upon the 2022 international HypoPT guidelines and three systematic review...
Exosomal miRNAs in muscle-bone crosstalk: Mechanistic links, exercise modulation and implications for sarcopenia, osteoporosis and osteosarcopenia [0.03%]
肌肉-骨骼交叉对话中的外泌体miRNA：机制联系、运动调节及肌少症、骨质疏松和肌骨减少症的含义
Bo Zhang,Yang Chen,Qiaojie Chen et al.
Bo Zhang et al.
This review investigates the emerging role of exosomal microRNAs (miRNAs) as pivotal mediators of bidirectional communication between the skeletal muscle and bone tissue, with significant implications for age-related musculoskeletal disorde...
Ying Liu,Qi Yao,Jiabin Yu et al.
Ying Liu et al.
Cardiovascular diseases (CVDs), the leading cause of global mortality, are now understood to be profoundly influenced by the endocrine regulatory functions of the skeletal system. Emerging evidence suggests that osteocrine factors, includin...
Glycine as a conditionally essential amino acid and its relationship to l-serine [0.03%]
甘氨酸作为条件性必需氨基酸及其与L-丝氨酸的关系
Milan Holeček
Milan Holeček
Glycine is a conditionally essential amino acid obtained from food and synthesized in the body, primarily from l-serine. Glycine deficiency has been reported due to inadequate protein intake, malnutrition, late gestation, diabetes, insulin ...
Expanding the clinical and immunogenomic relevance of SAMD1 in hepatocellular carcinoma [0.03%]
SAMD1在肝细胞癌临床和免疫基因组学中的意义扩大研究
Valbert Oliveira Costa Filho,Pedro Robson Costa Passos
Valbert Oliveira Costa Filho
NIPSNAP1 and NIPSNAP2 facilitate healthy aging independent of mitophagy [0.03%]
独立于线粒体自噬，NIPSNAP1和NIPSNAP2促进健康衰老
Jian Lv,Junmei Wang,Qin Chen et al.
Jian Lv et al.
Mitochondrial dysfunction is a hallmark of aging and has been implicated in aging-related diseases. NIPSNAP1 and NIPSNAP2 are functionally redundant homologs involved in mitochondrial quality control, yet their roles in healthy aging and lo...
USP48 protects against myocardial ischemia-reperfusion injury by stabilizing and upregulating CNN1 in type 1 diabetes mice [0.03%]
USP48通过稳定和上调CNN1来保护1型糖尿病小鼠免受心肌缺血再灌注损伤的影响
Jia-Bao Su,Guo Chen,Qing-Yi Sun et al.
Jia-Bao Su et al.
Ubiquitin-specific protease 48 (USP48) plays an important role in the regulation of DNA repair and immune signaling in health and diseases. Nonetheless, its implication in the development of diabetes-accelerated myocardial ischemia/reperfus...
Exercise mitigates liver senescence but does not outmatch dietary restriction in obesity-related MASLD [0.03%]
运动缓解非酒精性脂肪肝病相关的肝脏衰老但无法与饮食限制相媲美
Angeliki Katsarou,Grigorios Papadopoulos,Ioannis I Moustakas et al.
Angeliki Katsarou et al.
Background: The present study aims at deciphering the individual or combined benefits of aerobic exercise and dietary restriction on liver senescence, a state characterized by cell cycle arrest and simultaneous resistance...
Synergistic effects of CC chemokine receptor 2 inhibitor and transforming growth factor-β type I receptor kinase inhibitor combination in metabolic dysfunction-associated steatohepatitis [0.03%]
CC趋化因子受体2抑制剂与转化生长因子-βⅠ型受体激酶抑制剂联合用药在代谢功能障碍相关性肝炎中的协同作用
Su Ho Jo,Eun Soo Lee,So Bin Lee et al.
Su Ho Jo et al.
Background: Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive hepatic disorder characterized by its association with metabolic abnormalities, including obesity, hyperlipidemia, and type 2 diabetes m...
Sedentary behaviour and cardiometabolic health: Integrating the potential underlying molecular health aspects [0.03%]
久坐行为与心血管代谢健康：整合潜在的分子健康方面以改善心血管代谢健康
Wouter M A Franssen,Ine Nieste,Kenneth Verboven et al.
Wouter M A Franssen et al.
During the last decades, sedentary behaviour has been recognised as an interdependent risk factor for cardiometabolic health and premature mortality. Prolonged sedentary behaviour is associated with increased risks for chronic non-communica...