Ubiquitination of cytoplasmic HMGB1 by RNF186 regulates hepatic lipophagy in non-alcoholic fatty liver disease [0.03%]
RNF186介导的胞质HMGB1泛素化调控非酒精性脂肪肝病中的脂噬过程
Jiang Du,Xiang Ji,Bo Xu et al.
Jiang Du et al.
Background: Lipophagy is a vital biological process that maintains the balance of intracellular lipid metabolism in nonalcoholic fatty liver disease (NAFLD). However, the precise regulatory mechanism of RNF186 in hepatic ...
Impact of fasting on the AMPK and PGC-1α axis in rodent and human skeletal muscle: A systematic review [0.03%]
禁食对啮齿动物和人骨骼肌中AMPK和PGC-1α轴的影响：系统性回顾
K L Storoschuk,D Lesiuk,J Nuttall et al.
K L Storoschuk et al.
Based primarily on evidence from rodent models fasting is currently believed to improve metabolic health via activation of the AMPK-PGC-1α axis in skeletal muscle. However, it is unclear whether the skeletal muscle AMPK-PGC-1α axis is act...
TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics [0.03%]
TMEM135通过调节线粒体动力学来维持成骨和成脂平衡
Jia Liu,Xiaogang Bao,Jian Huang et al.
Jia Liu et al.
Background: Disturbance in the differentiation process of bone marrow mesenchymal stem cells (BMSCs) leads to osteoporosis. Mitochondrial dynamics plays a pivotal role in the metabolism and differentiation of BMSCs. Howev...
TOX3 deficiency mitigates hyperglycemia by suppressing hepatic gluconeogenesis through FoxO1 [0.03%]
TOX3 缺陷通过FoxO1抑制肝糖异生从而减轻高血糖症
Congcong Liu,Yuanwen Zheng,Shourui Hu et al.
Congcong Liu et al.
Background: Excessive hepatic glucose production is a hallmark that contributes to hyperglycemia in type 2 diabetes (T2D). The regulatory network governing this process remains incompletely understood. Here, we demonstrat...
Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD [0.03%]
运动诱导的线粒体融合蛋白-2通过调节脂滴-线粒体间通讯促进雄性非酒精性脂肪肝小鼠的脂肪酸氧化
Juan Carlos Bórquez,Francisco Díaz-Castro,Francisco Pino-de La Fuente et al.
Juan Carlos Bórquez et al.
Background and aim: The excessive accumulation of lipid droplets (LDs) is a defining characteristic of nonalcoholic fatty liver disease (NAFLD). The interaction between LDs and mitochondria is functionally important for l...
Martine Laville,Maud Robert,Bérénice Segrestin
Martine Laville
After bariatric surgery, patients with obesity achieve sustainable weight loss, gain in mobility, quality of life and life expectancy. Bariatric surgery can lead to remission of type 2 diabetes or to long term glycaemic control for patients...
Diabetic kidney disease in type 1 diabetes: challenges and differences from type 2 diabetes [0.03%]
1型糖尿病的糖尿病肾脏病：挑战与2型糖尿病的区别
Djordje S Popovic,Dimitrios Patoulias,Luigi Gnudi et al.
Djordje S Popovic et al.
Loss of mitochondrial adaptation associates with deterioration of mitochondrial turnover and structure in metabolic dysfunction-associated steatotic liver disease [0.03%]
与代谢功能异常相关脂肪肝病中线粒体适应性的丧失与线粒体周转和结构的恶化有关
Theresia Sarabhai,Sabine Kahl,Sofiya Gancheva et al.
Theresia Sarabhai et al.
Background: Obesity and type 2 diabetes frequently have metabolic dysfunction-associated steatotic liver disease (MASLD) including steatohepatitis (MASH). In obesity, the liver may adapt its oxidative capacity, but the ro...
Mitochondrial ribosomal protein L12 potentiates hepatocellular carcinoma by regulating mitochondrial biogenesis and metabolic reprogramming [0.03%]
线粒体核糖体蛋白L12通过调节线粒体生物生成和代谢重组促进肝细胞癌发展
Xingzhao Ji,Zhen Yang,Chensheng Li et al.
Xingzhao Ji et al.
Background: Mitochondrial dysfunction and metabolic reprogramming are key features of hepatocellular carcinoma (HCC). Despite its significance, the precise underlying mechanism behind these processes has not been fully el...
Plasma proteome profiling reveals metabolic and immunologic differences between Anorexia Nervosa subtypes [0.03%]
血浆蛋白质组分析揭示了神经性厌食症亚型之间的代谢和免疫学差异
Diana Samodova,August Hoel,Tue Haldor Hansen et al.
Diana Samodova et al.
Aims/hypothesis: Anorexia Nervosa (AN) is a severe psychiatric disorder of an unknown etiology with a crude mortality rate of about 5 % per decade, making it one of the deadliest of all psychiatric illnesses. AN is broadl...