Performance of non-invasive tests for liver fibrosis resolution after bariatric surgery [0.03%]
减重手术后肝纤维化缓解的无创检测性能研究
Violeta Raverdy,Federica Tavaglione,Estelle Chatelain et al.
Violeta Raverdy et al.
Background & aims: The value of non-invasive tests for monitoring the resolution of significant liver fibrosis after treatment is poorly investigated. We compared the performances of six non-invasive tests to predict the ...
Minireview: Understanding and targeting inflammatory, hemodynamic and injury markers for cardiorenal protection in type 1 diabetes [0.03%]
微型评论：理解和定位1型糖尿病中用于心脏肾脏保护的炎症，血流动力学和损伤标志物
Luxcia Kugathasan,Vikas S Sridhar,Kalie L Tommerdahl et al.
Luxcia Kugathasan et al.
The coexistence of cardiovascular disease (CVD) and diabetic kidney disease (DKD) is common in people with type 1 diabetes (T1D) and is strongly associated with an increased risk of morbidity and mortality. Hence, it is imperative to explor...
Empowering mitochondrial metabolism: Exploring L-lactate supplementation as a promising therapeutic approach for metabolic syndrome [0.03%]
增强线粒体代谢：探索L-乳酸补充作为治疗代谢综合征的有前途的方法
Ming Cai,Shuyao Li,Keren Cai et al.
Ming Cai et al.
Mitochondrial dysfunction plays a critical role in the pathogenesis of metabolic syndrome (MetS), affecting various cell types and organs. In MetS animal models, mitochondria exhibit decreased quality control, characterized by abnormal morp...
Bioengineering and vascularization strategies for islet organoids: advancing toward diabetes therapy [0.03%]
胰岛类器官的生物工程和血管化策略：迈向糖尿病治疗的方法
Jing Yang,Yuxin Yan,Xiya Yin et al.
Jing Yang et al.
Diabetes presents a pressing healthcare crisis, necessitating innovative solutions. Organoid technologies have rapidly advanced, leading to the emergence of bioengineering islet organoids as an unlimited source of insulin-producing cells fo...
Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner [0.03%]
锌指蛋白ZNF638通过依赖雌激素的ANGPTL8调节甘油三酯代谢
Meiyao Meng,Yuxiang Cao,Jin Qiu et al.
Meiyao Meng et al.
Background and aim: Triglyceride (TG) levels are closely related to obesity, fatty liver and cardiovascular diseases, while the regulatory factors and mechanism for triglyceride homeostasis are still largely unknown. Zinc...
Inhibition of PCSK9 prevents and alleviates cholesterol gallstones through PPARα-mediated CYP7A1 activation [0.03%]
通过PPARα介导的CYP7A1激活，抑制PCSK9可预防并缓解胆固醇胆结石
Zhenmei Chen,Weiqing Shao,Yitong Li et al.
Zhenmei Chen et al.
Background & aims: Dysregulated cholesterol metabolism is the major factor responsible for cholesterol gallstones (CGS). Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a critical role in cholesterol homeostas...
Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma [0.03%]
STAT3-NFkB信号的协同作用调节肝细胞癌中的线粒体功能障碍和代谢谱分析
Sharmeen Ishteyaque,Gurvinder Singh,Karan Singh Yadav et al.
Sharmeen Ishteyaque et al.
Background: Hepatocellular carcinoma (HCC) continues to pose a significant health challenge and is often diagnosed at advanced stages. Metabolic reprogramming is a hallmark of many cancer types, including HCC and it invol...
Bariatric surgery, through beneficial effects on underlying mechanisms, improves cardiorenal and liver metabolic risk over an average of ten years of observation: A longitudinal and a case-control study [0.03%]
减肥手术通过其对潜在机制的有益影响，在大约十年的观察期内改善了心肾和肝脏代谢风险：一项纵向研究和病例对照研究
Alexander Kokkinos,Dimitrios Tsilingiris,Stamatia Simati et al.
Alexander Kokkinos et al.
Background: Bariatric surgery has long-term beneficial effects on body weight and metabolic status, but there is an apparent lack of comprehensive cardiometabolic, renal, liver, and metabolomic/lipidomic panels, whereas t...
GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway [0.03%]
GDF15通过抑制TGF-β1/SMAD3通路激活AMPK并抑制肝脏的糖异生和纤维化
Javier Jurado-Aguilar,Emma Barroso,Maribel Bernard et al.
Javier Jurado-Aguilar et al.
Introduction: The levels of the cellular energy sensor AMP-activated protein kinase (AMPK) have been reported to be decreased via unknown mechanisms in the liver of mice deficient in growth differentiation factor 15 (GDF1...
Prashant Regmi,Morag Young,Gabriela Minigo et al.
Prashant Regmi et al.
Circadian rhythms are evolutionarily programmed biological rhythms that are primarily entrained by the light cycle. Disruption of circadian rhythms is an important risk factor for several metabolic disorders. Photoperiod is defined as total...