Identification of MGMT promoter methylation as a specific lipid metabolism biomarker, reveals the feasibility of atorvastatin application in glioblastoma [0.03%]
识别MGMT启动子甲基化作为特定的脂质代谢生物标志物，揭示了阿托伐他汀在胶质母细胞瘤中应用的可行性
Zhaonian Hao,Jiejun Wang,Yifan Lv et al.
Zhaonian Hao et al.
Background: Glioblastoma is one of the deadliest tumors, and limited improvement in managing glioblastoma has been achieved in the past decades. The unmethylated promoter area of 6-O-Methylguanine-DNA Methyltransferase (M...
LAT1-dependent placental methionine uptake is a key player in fetal programming of metabolic disease [0.03%]
依赖于LAT1的胎盘蛋氨酸吸收是胎儿代谢疾病发生的关键因素
Mariana Schroeder,Barbara Fuenzalida,Nan Yi et al.
Mariana Schroeder et al.
The Developmental Origins of Health and Disease hypothesis sustains that exposure to different stressors during prenatal development prepares the offspring for the challenges to be encountered after birth. We studied the gestational period ...
The risk and benefit of revisional vs. primary metabolic- bariatric surgery and drug therapy - A narrative review [0.03%]
修正代谢减肥手术与初次代谢减肥手术和药物治疗的风险和益处 – 叙述性评论
Sebastian Nedelcut,Stephan Axer,Torsten Olbers
Sebastian Nedelcut
Metabolic and bariatric surgery (MBS) leads to long-term weight loss, reduced risk of cardiovascular events and cancer, and reduced mortality. Sleeve gastrectomy and Roux-en-Y gastric bypass are currently the most common surgical techniques...
Steatotic liver disease predicts cardiovascular disease and advanced liver fibrosis: A community-dwelling cohort study with 20-year follow-up [0.03%]
脂肪肝疾病可预测心血管疾病及肝纤维化恶化：一项为期20年的社区队列研究
Hun Jee Choe,Joon Ho Moon,Won Kim et al.
Hun Jee Choe et al.
Background: Steatotic liver disease (SLD) has emerged as new nomenclature to increase awareness and reflect the pathophysiology of the disease better. We investigated the risk of advanced fibrosis and cardiovascular disea...
Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut microbiota in obese model mice [0.03%]
Imeglimin通过作用于肥胖模型小鼠的棕色脂肪组织和肠道微生物来改善全身新陈代谢
Motoharu Awazawa,Maya Matsushita,Ikumi Nomura et al.
Motoharu Awazawa et al.
Imeglimin is a recently developed anti-diabetic drug that could concurrently promote insulin secretion and insulin sensitivity, while its mechanisms of action are not fully understood. Here we show that imeglimin administration could protec...
Dysregulation of autophagy activation induced by atorvastatin contributes to new-onset diabetes mellitus in western diet-fed mice [0.03%]
阿托伐他汀诱导的自噬激活失调导致西式饮食喂养的小鼠发生新发糖尿病
Juhee Kim,Minjune Kim,Minjeong Kim et al.
Juhee Kim et al.
Background and aims: The incidence of statin-induced new-onset diabetes (NOD) is increasing but its underlying mechanisms remain unclear. We aimed to investigate the effects of various doses of atorvastatin (ATO)-induced ...
Effect of sodium-glucose cotransporter-2 inhibitors on continuous glucose monitoring metrics, as adjunctive to insulin in adults with type 1 diabetes mellitus: a meta-analysis of randomized controlled trials [0.03%]
钠-葡萄糖协同转运蛋白-2抑制剂作为胰岛素治疗的辅助手段对1型糖尿病成人连续血糖监测指标的影响：一项随机对照试验的荟萃分析
Djordje S Popovic,Paschalis Karakasis,Theocharis Koufakis et al.
Djordje S Popovic et al.
Aims: This meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effect of sodium-glucose cotransporter-2 inhibitors (SGLT2is) on continuous glucose monitoring metrics as adjunctive to insulin in adul...
A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation [0.03%]
一个小分子巨噬细胞迁移抑制因子激动剂通过代谢调节改善与年龄相关的心肌对缺血再灌注损伤的不耐受性
Hao Wang,Lily Slotabec,Steven Didik et al.
Hao Wang et al.
Macrophage migration inhibitory factor (MIF) is an innate cytokine that regulates both inflammatory and homeostatic responses. MIF is expressed by cardiomyocytes, where it exerts a protective action against ischemia-reperfusion (I/R) injury...
Mortality in metabolic dysfunction-associated steatotic liver disease: A nationwide population-based cohort study [0.03%]
与代谢功能障碍相关的脂肪肝疾病的死亡率：一项全国性人群队列研究
Eugene Han,Byung-Wan Lee,Eun Seok Kang et al.
Eugene Han et al.
Background: A new fatty liver disease nomenclature, steatotic liver disease (SLD) has been proposed; however, there are no data on clinical outcomes. We investigated the impact of SLD with metabolic dysfunction (MD; SLD-M...
Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction [0.03%]
人类内脏脂肪组织的临床和分子特征分析揭示血管结构和重塑的损伤是功能障碍的早期标志物
Daniela Rosendo-Silva,Pedro Bastos Gomes,Tiago Rodrigues et al.
Daniela Rosendo-Silva et al.
Adipose tissue dysfunction is more related to insulin resistance than body mass index itself and an alteration in adipose tissue function is thought to underlie the shift from metabolically healthy to unhealthy obesity. Herein, we performed...