Endothelial cell serum and glucocorticoid regulated kinase 1 (SGK1) mediates vascular stiffening [0.03%]
内皮细胞血清和糖皮质激素调节激酶1（SGK1）介导血管僵硬度的增加
Liping Zhang,Zhe Sun,Yan Yang et al.
Liping Zhang et al.
Background: Excessive dietary salt intake increases vascular stiffness in humans, especially in salt-sensitive populations. While we recently suggested that the endothelial sodium channel (EnNaC) contributes to salt-sensi...
Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis [0.03%]
非酒精性脂肪肝炎小鼠模型中扰动的肝脏基因分区
Ye Zhou,Yuanqi Zhao,Marisa Carbonaro et al.
Ye Zhou et al.
Liver zonation characterizes the separation of metabolic pathways along the lobules and is required for optimal hepatic function. Wnt signaling is a master regulator of spatial liver zonation. A perivenous-periportal Wnt activity gradient o...
Corrigendum to "Mortality in metabolic dysfunction-associated steatotic liver disease: A nationwide population-based cohort study" [Metabolism, Volume 152, March 2024, 155789] [0.03%]
《代谢功能障碍相关脂肪性肝病的死亡率：全国人群队列研究》[代谢，第152卷，2024年3月，155789]的勘误表
Eugene Han,Byung-Wan Lee,Eun Seok Kang et al.
Eugene Han et al.
Ketones provide an extra source of fuel for the failing heart without impairing glucose oxidation [0.03%]
酮类为衰弱的心脏提供额外的能量来源而不影响葡萄糖氧化
Simran Pherwani,David Connolly,Qiuyu Sun et al.
Simran Pherwani et al.
Background: Cardiac glucose oxidation is decreased in heart failure with reduced ejection fraction (HFrEF), contributing to a decrease in myocardial ATP production. In contrast, circulating ketones and cardiac ketone oxid...
Are we underestimating the potential of neuroactive drugs to augment neuromotor function in sarcopenia? [0.03%]
我们是否低估了神经营养药物在肌减少症中增强神经肌肉功能的潜力？
Lucas B R Orssatto,Jacob R Thorstensen,David Scott et al.
Lucas B R Orssatto et al.
Nonlinear relationship between high-density lipoprotein cholesterol and cardiovascular disease: an observational and Mendelian randomization analysis [0.03%]
高密度脂蛋白胆固醇与心血管疾病之间的非线性关系：观察性和孟德尔随机化分析
Jun-Xiang Chen,Yue Li,Yan-Bo Zhang et al.
Jun-Xiang Chen et al.
Background: Clinical trials and Mendelian randomization (MR) studies reported null effects of high-density lipoprotein cholesterol (HDL-C) on risk of cardiovascular disease (CVD), which might have overlooked a nonlinear c...
Observational Study
Metabolism: clinical and experimental. 2024 May:154:155817. DOI:10.1016/j.metabol.2024.155817 2024
Mortality risk in patients with obesity and COVID-19 infection: a systematic review and meta-analysis [0.03%]
肥胖和COVID-19感染患者的死亡风险：系统评价和荟萃分析
Rachelle Haber,Malak Ghezzawi,Houry Puzantian et al.
Rachelle Haber et al.
Obesity is a risk factor for severe respiratory diseases, including COVID-19 infection. Meta-analyses on mortality risk were inconsistent. We systematically searched 3 databases (Medline, Embase, CINAHL) and assessed the quality of studies ...
Autophagy and the unfolded protein response shape the non-alcoholic fatty liver landscape: decoding the labyrinth [0.03%]
自噬和未折叠蛋白反应塑造非酒精性脂肪肝景观：解码迷宫
Zahra Dashti,Zeynab Yousefi,Pouria Kiani et al.
Zahra Dashti et al.
The incidence of nonalcoholic fatty liver disease (NAFLD) is on the rise, mirroring a global surge in diabetes and metabolic syndrome, as its major leading causes. NAFLD represents a spectrum of liver disorders, ranging from nonalcoholic fa...
Corrigendum to "Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma" [Metabolism, Volume 152, March 2024, 155771] [0.03%]
勘误表：“合作的STAT3-NFκB信号调节肝细胞癌中的线粒体功能障碍和代谢谱”[代谢，卷152，2024年3月，155771]
Sharmeen Ishteyaque,Gurvinder Singh,Karan Singh Yadav et al.
Sharmeen Ishteyaque et al.
Intermittent fasting protects β-cell identity and function in a type-2 diabetes model [0.03%]
间歇性禁食保护了二型糖尿病模型中的β细胞的身份和功能
Sumit Patel,Zihan Yan,Maria S Remedi
Sumit Patel
Type 2 diabetes (T2DM) is caused by the interaction of multiple genes and environmental factors. T2DM is characterized by hyperglycemia, insulin secretion deficiency and insulin resistance. Chronic hyperglycemia induces β-cell dysfunction,...