Xiaodong Zhao,Yunkuo Li,Jinyu Yu et al.
Xiaodong Zhao et al.
Renal fibrosis, specifically tubulointerstitial fibrosis, represents the predominant pathological consequence observed in the context of progressive chronic kidney conditions. The pathogenesis of renal fibrosis encompasses a multifaceted in...
Deciphering the molecular pathways of saroglitazar: A dual PPAR α/γ agonist for managing metabolic NAFLD [0.03%]
萨罗格列扎的分子通路研究：一种用于治疗代谢性NAFLD的PPARα/γ双重激动剂
Devaraj Ezhilarasan
Devaraj Ezhilarasan
Saroglitazar (SARO), a dual peroxisome proliferator activated receptor (PPAR)-α/γ agonist, has been used to treat metabolic diseases such as insulin resistance and diabetic dyslipidemia in patients with non-alcoholic fatty liver disease (...
Myeloid Trem2 ameliorates the progression of metabolic dysfunction-associated steatotic liver disease by regulating macrophage pyroptosis and inflammation resolution [0.03%]
小胶质细胞Trem2通过调节巨噬细胞焦亡和炎症反应来改善代谢功能异常相关肝脂肪变性疾病的发展进程
Wenjie Yu,Yu Zhang,Linfeng Sun et al.
Wenjie Yu et al.
Background: The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing year by year and has become one of the leading causes of end-stage liver disease worldwide. Triggering Receptor ...
Baseline phenotypes with preserved β-cell function and high insulin concentrations have the best improvements in glucose tolerance after weight loss: results from the prospective DEXLIFE and EGIR-RISC studies [0.03%]
基线β细胞功能良好及胰岛素浓度较高的患者在减重后糖耐量改善最佳：前瞻性DEXLIFE和EGIR-RISC研究结果
Silvia Sabatini,John J Nolan,Grainne O&#x;Donoghue et al.
Silvia Sabatini et al.
Background: Weight loss and lifestyle intervention improve glucose tolerance delaying the onset of type 2 diabetes (T2D), but individual responses are highly variable. Determining the predictive factors linked to the bene...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2024 Jun:155:155910. DOI:10.1016/j.metabol.2024.155910 2024
Krüppel-like factor 10 protects against metabolic dysfunction-associated steatohepatitis by regulating HNF4α-mediated metabolic pathways [0.03%]
Krüppel样因子10通过调节HNF4α介导的代谢途径对抗与代谢功能障碍相关的steatohepatitis（代谢性肝炎）
Xiaoli Pan,Shuwei Hu,Yanyong Xu et al.
Xiaoli Pan et al.
Background: Krüppel-like factor 10 (KLF10), a zinc finger transcription factor, plays a pivotal role in modulating TGF-β-mediated cellular processes such as growth, apoptosis, and differentiation. Recent studies have im...
Interplay of CD36, autophagy, and lipid metabolism: insights into cancer progression [0.03%]
CD36、自噬与脂质代谢的相互作用：深入探究癌症进展
Yuxuan Yang,Xiaokun Liu,Di Yang et al.
Yuxuan Yang et al.
CD36, a scavenger receptor B2 that is dynamically distributed between cell membranes and organelle membranes, plays a crucial role in regulating lipid metabolism. Abnormal CD36 activity has been linked to a range of metabolic disorders, suc...
Resmetirom, the first approved drug for the management of metabolic dysfunction-associated steatohepatitis: Trials, opportunities, and challenges [0.03%]
尼美利酮——首个获批的代谢性失调相关脂肪肝病药物：试验、机遇和挑战
Michail Kokkorakis,Chrysoula Boutari,Michael A Hill et al.
Michail Kokkorakis et al.
Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice [0.03%]
小鼠日间运动后代谢的可塑性以及肥胖相关的代谢变化
Logan A Pendergrast,Stephen P Ashcroft,Amy M Ehrlich et al.
Logan A Pendergrast et al.
Background: Circadian disruption is widespread and increases the risk of obesity. Timing of therapeutic interventions may promote coherent and efficient gating of metabolic processes and restore energy homeostasis. ...
Non-coding RNAs in diabetic peripheral neuropathy: their role and mechanisms underlying their effects [0.03%]
糖尿病外周神经病变中的非编码RNA：它们的作用及其影响的机制
Yiqian He,Ling Qu
Yiqian He
Diabetic peripheral neuropathy (DPN) is a complication of diabetes with a high rate of disability. However, current clinical treatments for DPN are suboptimal. Non-coding RNAs (ncRNAs) are a type of RNAs that are not translated into protein...
Interleukin-6 classic and trans-signaling utilize glucose metabolism reprogramming to achieve anti- or pro-inflammatory effects [0.03%]
白细胞介素6经典和转信号利用糖代谢重建来实现抗炎或促炎作用
Shilei Xu,Ke-Qiong Deng,Chengbo Lu et al.
Shilei Xu et al.
Interleukin (IL)-6 has anti- and pro-inflammatory functions, controlled by IL-6 classic and trans-signaling, respectively. Differences in the downstream signaling mechanism between IL-6 classic and trans-signaling have not been identified. ...