cGAS suppresses β-cell proliferation by a STING-independent but CEBPβ-dependent mechanism [0.03%]
cGAS通过STING非依赖但CEBPβ依赖的方式抑制胰岛素分泌细胞的增殖
Zixin Cai,Yan Yang,Jiaxin Zhong et al.
Zixin Cai et al.
Aims/hypothesis: cGAS (cyclic GMP-AMP synthase) has been implicated in various cellular processes, but its role in β-cell proliferation and diabetes is not fully understood. This study investigates the impact of cGAS on ...
The evolutionary conserved miR-137/325 tandem mediates obesity-induced hypogonadism and metabolic comorbidities by repressing hypothalamic kisspeptin [0.03%]
进化上保守的miR-137/325串联通过抑制下丘脑亲吻肽介导肥胖引起的性腺功能减退和代谢并发症
María S Avendaño,Cecilia Perdices-Lopez,Yolanda Guerrero-Ruiz et al.
María S Avendaño et al.
Background: Obesity-induced hypogonadism (OIH) is a prevalent, but often neglected condition in men, which aggravates the metabolic complications of overweight. While hypothalamic suppression of Kiss1-encoded kisspeptin h...
Statin treatment reduces leucine turnover, but does not affect endogenous production of beta-hydroxy-beta-methylbutyrate (HMB) [0.03%]
他汀类药物治疗可降低亮氨酸的周转率，但不影响β-羟基-β-甲基丁酸（HMB）的内源性生成
Martin Hagve,Suzette L Pereira,Dillon K Walker et al.
Martin Hagve et al.
Background: Statins, or hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors, are one of the most commonly prescribed medications for lowering cholesterol. Myopathic side-effects ranging from pain and sorenes...
Obesity and dyslipidemia in early life: Impact on cardiometabolic risk [0.03%]
早期生命中的肥胖和血脂异常：对代谢综合征风险的影响
Aleksandra Zeljkovic,Jelena Vekic,Aleksandra Stefanovic
Aleksandra Zeljkovic
Childhood obesity with its growing prevalence worldwide presents one of the most important health challenges nowadays. Multiple mechanisms are involved in the development of this condition, as well as in its associations with various cardio...
Corrigendum to "FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis" [Metabolism 122 (September 2021) 154840] [0.03%]
“FUNDC1不足通过ACSL4介导的铁死亡使高脂饮食引起的心脏重塑和收缩异常敏感化”元文章[代谢122（2021年9月）154840]校正字母表补充更正通知
Zhaohui Pei,Yandong Liu,Suqin Liu et al.
Zhaohui Pei et al.
O-GlcNAcylation promotes the progression of nonalcoholic fatty liver disease by upregulating the expression and function of CD36 [0.03%]
O-GlcNAc酰化通过上调CD36的表达和功能促进非酒精性脂肪肝病的发展
Hanlong Zhu,Tianming Zhao,Si Zhao et al.
Hanlong Zhu et al.
Background and aims: Nonalcoholic fatty liver disease (NAFLD) and its progressive variant, nonalcoholic steatohepatitis (NASH), constitute a burgeoning worldwide epidemic with no FDA-approved pharmacotherapies. The multif...
Virus-induced diabetes mellitus: revisiting infection etiology in light of SARS-CoV-2 [0.03%]
病毒引起的糖尿病：鉴于SARS-CoV-2重新审视感染病因学
Sundararaj Stanleyraj Jeremiah,Abu Saleh Md Moin,Alexandra E Butler
Sundararaj Stanleyraj Jeremiah
Diabetes mellitus (DM) is comprised of two predominant subtypes: type 1 diabetes mellitus (T1DM), accounting for approximately 5 % of cases worldwide and resulting from autoimmune destruction of insulin-producing β-cells, and type 2 (T2DM)...
Glucagon augments the secretion of FGF21 and GDF15 in MASLD by indirect mechanisms [0.03%]
glucagon通过间接机制增加MASLD患者FGF21和GDF15的分泌
Michael M Richter,Ida M Kemp,Sara Heebøll et al.
Michael M Richter et al.
Introduction: Glucagon receptor agonism is currently explored for the treatment of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). The metabolic effects of glucagon receptor agonism may in pa...
Corrigendum to "Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut microbiota in obese model mice" [Metabolism 153 (April 2024) 155796] [0.03%]
“依格列明通过靶向肥胖模型小鼠的棕色脂肪组织和肠道微生物群来改善全身代谢”的勘误表 [新陈代谢(2024年4月，第153期 155796)]
Motoharu Awazawa,Maya Matsushita,Ikumi Nomura et al.
Motoharu Awazawa et al.
Hepatic Klf10-Fh1 axis promotes exercise-mediated amelioration of NASH in mice [0.03%]
肝脏Klf10-Fh1轴促进运动改善小鼠NASH
Hong-Yang Luo,Wang-Jing Mu,Min Chen et al.
Hong-Yang Luo et al.
Exercise is an effective non-pharmacological strategy for the treatment of nonalcoholic steatohepatitis (NASH), but the underlying mechanism needs further investigation. Kruppel-like factor 10 (Klf10) is a transcriptional factor that is exp...