Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men [0.03%]
二甲双胍通过改变肠道菌群和血浆代谢组改善男性认知功能的机制研究
Marisel Rosell-Díaz,Anna Petit-Gay,Clàudia Molas-Prat et al.
Marisel Rosell-Díaz et al.
Background: An altered gut microbiome characterized by reduced abundance of butyrate producing bacteria and reduced gene richness is associated with type 2 diabetes (T2D). An important complication of T2D is increased ris...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2024 Aug:157:155941. DOI:10.1016/j.metabol.2024.155941 2024
The mitochondrial TSPO ligand Atriol mitigates metabolic-associated steatohepatitis by downregulating CXCL1 [0.03%]
线粒体TSPO配体Atriol通过下调CXCL1缓解代谢性肝炎
Yuchang Li,Liting Chen,Chantal Sottas et al.
Yuchang Li et al.
Background and aims: The mitochondrial translocator protein (TSPO, 18 kDa) is pivotal in binding cholesterol and facilitating its transfer from the outer to the inner mitochondrial membrane. Atriol is a TSPO ligand disrup...
DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases [0.03%]
DCRM 2.0：糖尿病、心血管肾脏及代谢性疾病多学科联合诊疗建议
Yehuda Handelsman,John E Anderson,George L Bakris et al.
Yehuda Handelsman et al.
The spectrum of cardiorenal and metabolic diseases comprises many disorders, including obesity, type 2 diabetes (T2D), chronic kidney disease (CKD), atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), dyslipidemias, hyperten...
Diacylglycerol kinase delta overexpression improves glucose clearance and protects against the development of obesity [0.03%]
二酰基甘油激酶delta过表达改善血糖清除并预防肥胖发生
Maxence Jollet,Flavia Tramontana,Lake Q Jiang et al.
Maxence Jollet et al.
Background and aim: Diacylglycerol kinase (DGK) isoforms catalyze an enzymatic reaction that removes diacylglycerol (DAG) and thereby terminates protein kinase C signaling by converting DAG to phosphatidic acid. DGKδ (ty...
Regulation of hepatic lipogenesis by asymmetric arginine methylation [0.03%]
不对称精氨酸甲基化介导的肝脂质合成调节机制研究
Hye-Sook Han,Byeong Hun Choi,Seo Young Jang et al.
Hye-Sook Han et al.
Background and aims: Hepatic lipogenesis is elevated in nutrient abundant conditions to convert the excess carbohydrate into triacylglycerol (TAG). Fatty acyl moiety of TAG is eventually transported into adipose tissues b...
Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease? [0.03%]
肥胖与MASLD：代谢性肝病的治疗关键在于（仅）减重吗？
Maximilian Huttasch,Michael Roden,Sabine Kahl
Maximilian Huttasch
Metabolic dysfunction-associated steatotic liver disease (MASLD) closely associates with obesity and type 2 diabetes. Lifestyle intervention and bariatric surgery aiming at substantial weight loss are cornerstones of MASLD treatment by impr...
Metabolic dysfunction-associated steatotic liver disease: Recent turning points for its diagnosis and management [0.03%]
与代谢紊乱相关的肝脂肪变性疾病：诊断和治疗的新进展
Stergios A Polyzos,Christos S Mantzoros
Stergios A Polyzos
Estradiol contributes to sex differences in resilience to sepsis-induced metabolic dysregulation and dysfunction in the heart via GPER-1-mediated PPARδ/NLRP3 signaling [0.03%]
雌二醇通过GPER-1介导的PPARδ/NLRP3信号途径对脓毒症诱导的心脏代谢失调和功能障碍产生影响并导致性别差异
Joseph Adu-Amankwaah,Adebayo Oluwafemi Adekunle,Ziqing Tang et al.
Joseph Adu-Amankwaah et al.
Background and aim: Clinically, septic males tend to have higher mortality rates, but it is unclear if this is due to sex differences in cardiac dysfunction, possibly influenced by hormonal variations. Cardiac dysfunction...
Resmetirom for MASH patients with diabetes: challenges and opportunities in the real world [0.03%]
糖尿病MAS患者使用Resmetirom的现实世界挑战与机遇
Li-You Lian,Giovanni Targher,Christopher D Byrne et al.
Li-You Lian et al.
cGAS suppresses β-cell proliferation by a STING-independent but CEBPβ-dependent mechanism [0.03%]
cGAS通过STING非依赖但CEBPβ依赖的方式抑制胰岛素分泌细胞的增殖
Zixin Cai,Yan Yang,Jiaxin Zhong et al.
Zixin Cai et al.
Aims/hypothesis: cGAS (cyclic GMP-AMP synthase) has been implicated in various cellular processes, but its role in β-cell proliferation and diabetes is not fully understood. This study investigates the impact of cGAS on ...