Adriana Fontes,Hannah Pierson,Joanna B Bierła et al.
Adriana Fontes et al.
In Wilson disease (WD), liver copper (Cu) excess, caused by mutations in the ATPase Cu transporting beta (ATP7B), has been extensively studied. In contrast, in the gastrointestinal tract, responsible for dietary Cu uptake, ATP7B malfunction...
New insights into the function of the NLRP3 inflammasome in sarcopenia: mechanism and therapeutic strategies [0.03%]
NLRP3炎性小体在肌少症功能中的新见解：机制与治疗策略
Yunyi Zou,Xiangbin Tang,Siyuan Yang et al.
Yunyi Zou et al.
Sarcopenia is one of the most common skeletal muscle disorders and is characterized by infirmity and disability. While extensive research has focused on elucidating the mechanisms underlying the progression of sarcopenia, further comprehens...
Fasting-induced miR-7a-5p in AgRP neurons regulates food intake [0.03%]
AGRPR神经元中由禁食诱导的miR-7a-5p调节摄食量
Mingyang Yuan,Zhiwen Cao,Qian Li et al.
Mingyang Yuan et al.
Objective: The molecular control of feeding after fasting is essential for maintaining energy homeostasis, while overfeeding usually leads to obesity. Identifying non-coding microRNAs (miRNAs) that control food intake cou...
Disparities in metabolic dysfunction-associated steatotic liver disease and cardiometabolic conditions in low and lower middle-income countries: a systematic analysis from the global burden of disease study 2019 [0.03%]
全球疾病负担研究（2019）中低收入国家代谢功能障碍相关肝病及其心血管和代谢性疾病不平等的系统分析
Pojsakorn Danpanichkul,Kanokphong Suparan,Priyata Dutta et al.
Pojsakorn Danpanichkul et al.
Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) and cardiometabolic conditions affect populations across economic strata. Nevertheless, there are limited epidemiological studies addressing thes...
Lactate and lactylation in cardiovascular diseases: current progress and future perspectives [0.03%]
乳酸与乳酸化在心血管疾病中的作用：进展与展望
Wengen Zhu,Siyu Guo,Junyi Sun et al.
Wengen Zhu et al.
Cardiovascular diseases (CVDs) are often linked to structural and functional impairments, such as heart defects and circulatory dysfunction, leading to compromised peripheral perfusion and heightened morbidity risks. Metabolic remodeling, p...
Characterization of the plasma metabolome and lipidome in response to sleeve gastrectomy and gastric bypass surgeries reveals molecular patterns of surgical weight loss [0.03%]
胃袖状切除术和胃旁路手术对血浆代谢组和脂质组的重塑揭示了术后体重减轻的分子模式
Minoo Bagheri,Kahraman Tanriverdi,Mark D Iafrati et al.
Minoo Bagheri et al.
Objectives: Bariatric surgery improves metabolic health, but the underlying mechanisms are not fully understood. We analyzed the effects of two types of bariatric surgery, sleeve gastrectomy (SG) and Roux-en-Y gastric byp...
The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis [0.03%]
脂多糖-TLR4轴调节肝谷氨酰胺酶1表达促进脂肪性肝病进展为脂肪肝炎时肝脏氨堆积
Maria Mercado-Gómez,Naroa Goikoetxea-Usandizaga,Annarein J C Kerbert et al.
Maria Mercado-Gómez et al.
Introduction: Ammonia is a pathogenic factor implicated in the progression of metabolic-associated steatotic liver disease (MASLD). The contribution of the glutaminase 1 (GLS) isoform, an enzyme converting glutamine to gl...
Targeting the regulation of iron homeostasis as a potential therapeutic strategy for nonalcoholic fatty liver disease [0.03%]
靶向铁稳态调节作为治疗非酒精性脂肪肝病的潜在策略
Yutong Sui,Xue Geng,Ziwei Wang et al.
Yutong Sui et al.
With aging and the increasing incidence of obesity, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide. NAFLD mainly includes simple hepatic steatosis, nonalcoholic steatohepatitis (NASH), li...
Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold [0.03%]
肾上腺素能神经通过CREB/CRTC2通路激活冷应激下肝脏糖异生作用
Henrique J N Morgan,Heitor B P Delfino,Aline Z Schavinski et al.
Henrique J N Morgan et al.
Background and aim: Although it is well established that hormones like glucagon stimulates gluconeogenesis via the PKA-mediated phosphorylation of CREB and dephosphorylation of the cAMP-regulated CREB coactivators CRTC2, ...
Global, regional, and national trends in metabolic risk factor-associated mortality among the working-age population from 1990-2019: An age-period-cohort analysis of the Global Burden of Disease 2019 study [0.03%]
1990年至2019年全球、区域和国家水平上代谢性危险因素相关死亡的变化趋势——全球疾病负担研究（GBD）年龄队列分析
Xiao-Lu Lin,Qing-Wei Zhang,Gui-Fen Chen et al.
Xiao-Lu Lin et al.
Background: Metabolic diseases contribute significantly to premature mortality worldwide, with increasing burdens observed among the working-age population (WAP). This study assessed global, regional, and national trends ...