Longitudinal proteomics of leptin treatment in humans with acute and chronic energy deficiency-induced hypoleptinemia reveal novel, mainly immune-related, pleiotropic effects [0.03%]
纵向蛋白质组学揭示了人在急性和慢性能量缺乏引起的低瘦素血症中接受瘦素治疗后产生了许多主要与免疫相关的多效性作用
Konstantinos Stefanakis,Martina Samiotaki,Vassiliki Papaevangelou et al.
Konstantinos Stefanakis et al.
Background: Leptin is known for its metabolic, immunomodulatory and neuroendocrine properties, but the full spectrum of molecules downstream of leptin and relevant underlying mechanisms remain to be fully clarified. Our o...
Randomized Controlled Trial
Metabolism: clinical and experimental. 2024 Oct:159:155984. DOI:10.1016/j.metabol.2024.155984 2024
RIPK3 causes mitochondrial dysfunction and albuminuria in diabetic podocytopathy through PGAM5-Drp1 signaling [0.03%]
RIPK3通过PGAM5-Drp1信号通路引起糖尿病足细胞病的线粒体功能障碍和蛋白尿
Jeong Suk Kang,Nam-Jun Cho,Seong Woo Lee et al.
Jeong Suk Kang et al.
Background: Receptor-interacting protein kinase (RIPK)3 is an essential molecule for necroptosis and its role in kidney fibrosis has been investigated using various kidney injury models. However, the relevance and the und...
Regional gray matter changes in steatotic liver disease provide a neurobiological link to depression: A cross-sectional UK Biobank cohort study [0.03%]
脂肪肝病的区域性灰质改变为其与抑郁之间的神经生物学联系提供了证据：一项来自英国生物银行队列的研究
Dominic Arold,Stefan R Bornstein,Nikolaos Perakakis et al.
Dominic Arold et al.
Background: Steatotic liver disease (SLD) is characterized by excessive accumulation of lipids in the liver. It is associated with elevated risk of hepatic and cardiometabolic diseases, as well as mental disorders such as...
Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19 [0.03%]
严重COVID-19患者肾上腺皮质类固醇生成增强和糖皮质激素反应减弱
Tian-Zi Wen,Tian-Ran Li,Xin-Yu Chen et al.
Tian-Zi Wen et al.
Background: The effect of coronavirus disease 2019 (COVID-19) on adrenal endocrine metabolism in critically ill patients remains unclear. This study aimed to investigate the alterations in adrenal steroidogenic activity, ...
Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy [0.03%]
抑制RCAN1可缓解糖尿病心肌病中的脂质蓄积和线粒体分裂
Songren Shu,Hao Cui,Zirui Liu et al.
Songren Shu et al.
Background: Although metabolic disturbance is a characteristic of diabetic cardiomyopathy (DbCM), the detailed pathogenesis of DbCM remains unknown. Metho...
Association of fatty liver index with sudden cardiac arrest in young adults [0.03%]
脂肪肝指数与年轻人突发性心脏骤停的关联研究
Joo Hee Jeong,Yun Gi Kim,Kyung-Do Han et al.
Joo Hee Jeong et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) contributes to cardiovascular events. Therefore, we aimed to identify the association of MASLD, as indicated by the fatty liver index (FLI), on ...
Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis [0.03%]
心脏祖细胞LGR6通过调节线粒体生物发生缓解糖尿病心肌病铁死亡
Mengmeng Zhao,Zican Shen,Zihui Zheng et al.
Mengmeng Zhao et al.
Aims: The majority of people with diabetes are susceptible to cardiac dysfunction and heart failure, and conventional drug therapy cannot correct the progression of diabetic cardiomyopathy. We assessed the potential role ...
Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism [0.03%]
tanicyte中雌激素受体-α信号位于生育和代谢的交叉路口
Daniela Fernandois,Mariam Rusidzé,Helge Mueller-Fielitz et al.
Daniela Fernandois et al.
Background: Estrogen secretion by the ovaries regulates the hypothalamic-pituitary-gonadal axis during the reproductive cycle, influencing gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion, and ...
Intricate interplay between cell metabolism and necroptosis regulation in metabolic dysfunction-associated steatotic liver disease: A narrative review [0.03%]
细胞代谢与坏死性凋亡在代谢功能障碍相关性肝脂肪变性疾病中的相互调节：叙事综述
Marta Bento Afonso,Jan Caira David,Mariana Isabel Alves et al.
Marta Bento Afonso et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), encompasses a progressive spectrum of liver conditions, ranging from steatosis to metabolic dysfunction-associate...
Metabolic reprogramming in septic acute kidney injury: pathogenesis and therapeutic implications [0.03%]
脓毒症急性肾损伤的代谢重组：发病机制和治疗意义
Caihong Liu,Wei Wei,Yongxiu Huang et al.
Caihong Liu et al.
Acute kidney injury (AKI) is a frequent and severe complication of sepsis and is characterized by significant mortality and morbidity. However, the pathogenesis of septic acute kidney injury (S-AKI) remains elusive. Metabolic reprogramming,...