Metabolic dysfunction-associated steatotic liver disease and its link to cancer [0.03%]
与代谢功能异常相关的脂肪性肝病及其与癌症的关系
Markos Kalligeros,Linda Henry,Zobair M Younossi
Markos Kalligeros
Metabolic-dysfunction associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), is a growing global health concern with significant implications for oncogenesis. This review synthesizes current ...
Metabolic dysfunction-associated steatotic liver disease and extrahepatic gastrointestinal cancers [0.03%]
与代谢功能异常相关的脂肪性肝病和消化系统癌症
Alessandro Mantovani,Amedeo Lonardo,Norbert Stefan et al.
Alessandro Mantovani et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) poses a significant and ever-increasing health and economic burden worldwide. Substantial epidemiological evidence shows that MASLD is a multisystem disease that is associated...
Placental growth factor deficiency initiates obesity- and aging-associated metabolic syndrome [0.03%]
胎盘生长因子缺乏引发肥胖和衰老相关的代谢综合征
Ji Hee Lim,Yaeni Kim,Min Young Kim et al.
Ji Hee Lim et al.
Obesity often leads to inadequate angiogenesis in expanding adipose tissue, resulting in inflammation and insulin resistance. We explored the role of placental growth factor (PlGF) in metabolic syndrome (MS) using mice models of type 2 diab...
Targeting endothelial KCa channels in vivo restores arterial and endothelial function in type 2 diabetic rats [0.03%]
靶向体内内皮KCa通道可恢复2型糖尿病大鼠动脉和内皮功能
Ramesh C Mishra,Darrell D Belke,Latika Singh et al.
Ramesh C Mishra et al.
Objective: This study tested the hypothesis that administration of the KCa channel activator SKA-31 restores endothelium-dependent vasodilation in vivo in Type 2 Diabetic (T2D) rats. ...
Huai Zhang,Xiao-Dong Zhou,Michael D Shapiro et al.
Huai Zhang et al.
Background: Common metabolic diseases, such as type 2 diabetes mellitus (T2DM), hypertension, obesity, hypercholesterolemia, and metabolic dysfunction-associated steatotic liver disease (MASLD), have become a global healt...
Steatotic liver disease in the context of hematological malignancies and anti-neoplastic chemotherapy [0.03%]
血液系统恶性肿瘤和抗肿瘤化疗背景下的肝脂肪变性及其引发的肝病
Charalampos G Pontikoglou,Theodosios D Filippatos,Angelos Matheakakis et al.
Charalampos G Pontikoglou et al.
The rising prevalence of obesity-related illnesses, such as metabolic steatotic liver disease (MASLD), represents a significant global public health concern. This disease affects approximately 30 % of the adult population and is the result ...
Management of patients with the cardio renal liver metabolic syndrome: The need for a multidisciplinary approach in research, education and practice [0.03%]
心血管-肾脏-肝脏代谢综合征患者的管理：研究、教育和实践中需要多学科方法应对
Angeliki M Angelidi,Despina Sanoudou,Michael A Hill et al.
Angeliki M Angelidi et al.
Tiantian Wang,Dong Zhou,Zhen Hong
Tiantian Wang
Sarcopenia is a geriatric syndrome characterized by a functional decline in muscle. The prevalence of sarcopenia increases with natural aging, becoming a serious health problem among elderly individuals. Therefore, understanding the patholo...
Identifying genetic determinants of sarcopenia-related traits: a Mendelian randomization study of druggable genes [0.03%]
药物基因靶点调控肌肉减少症相关特征的遗传决定因子识别研究：一项孟德尔随机化研究
Jihao Wu,Xiong Chen,Ruijun Li et al.
Jihao Wu et al.
Background: Sarcopenia, characterized by progressive muscle mass and function loss, particularly affects the elderly, and leads to severe consequences such as falls and mortality. Despite its prevalence, targeted pharmaco...
Cannabinoid receptor 2 plays a key role in renal fibrosis through inhibiting lipid metabolism in renal tubular cells [0.03%]
大麻素受体2通过抑制肾小管细胞脂质代谢在肾纤维化中发挥关键作用
Shan Zhou,Xian Ling,Ye Liang et al.
Shan Zhou et al.
Aims: Renal fibrosis is a common feature in various chronic kidney diseases (CKD). Tubular cell damage is a main characterization which results from dysregulated fatty acid oxidation (FAO) and lipid accumulation. Cannabin...