Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition [0.03%]
支链氨基酸代谢稳态失衡通过促进炎症和上皮间质转化加重糖尿病肾病发病进展
Xiaoqing Deng,Chao Tang,Ting Fang et al.
Xiaoqing Deng et al.
Background and aims: The disrupted homeostasis of branched-chain amino acids (BCAAs, including leucine, isoleucine, and valine) has been strongly correlated with diabetes with a potential causal role. However, the relatio...
Seven glucagon-like peptide-1 receptor agonists and polyagonists for weight loss in patients with obesity or overweight: an updated systematic review and network meta-analysis of randomized controlled trials [0.03%]
七种胰高血糖素样肽-1受体激动剂及泛激动剂用于肥胖或超重患者减重的系统评价和网状Meta分析
Zeyu Xie,Guimei Zheng,Zhuoru Liang et al.
Zeyu Xie et al.
Purpose: This study aimed to provide evidence-based support and a reference for the efficacy and safety of seven glucagon-like peptide-1 (GLP-1) receptor agonists and polyagonists for weight loss in patients with obesity ...
Inter-organ cross-talk in human cancer cachexia revealed by spatial metabolomics [0.03%]
空间代谢组学揭示的人类癌症恶病质的器官间交叉通讯
Na Sun,Tanja Krauss,Claudine Seeliger et al.
Na Sun et al.
Background: Cancer cachexia (CCx) presents a multifaceted challenge characterized by negative protein and energy balance and systemic inflammatory response activation. While previous CCx studies predominantly focused on m...
Corrigendum to "PCSK7: A novel regulator of apolipoprotein B and a potential target against non-alcoholic fatty liver disease" [Metabolism Volume 150, January 2024, 155736, PMID: 7967646] [0.03%]
“PCSK7：一种新型的载脂蛋白B调节因子及潜在的非酒精性脂肪肝病治疗靶点”一文的勘误（代谢 Volume 150，2024年1月，155736，PMID: 7967646）
Vatsal Sachan,Maïlys LeDévéhat,Anna Roubtsova et al.
Vatsal Sachan et al.
The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus [0.03%]
饮食干预在代谢紊乱相关性非酒精性脂肪性肝病防治中的作用：国际多学科专家共识
Xu-Fen Zeng,Krista A Varady,Xiang-Dong Wang et al.
Xu-Fen Zeng et al.
Metabolic dysfunction-associated fatty liver disease (MAFLD) or metabolic dysfunction-associated steatotic liver disease (MASLD), has become the leading cause of chronic liver disease worldwide. Optimal dietary intervention strategies for M...
Life's essential 8 and cardiovascular diseases progression among adults in the United Kingdom [0.03%]
英国成年人生活必需的8要素与心血管疾病进展的关系
Huangda Guo,Siyue Wang,Hexiang Peng et al.
Huangda Guo et al.
Background: Recently, the American Heart Association introduced Life's Essential 8 (LE8) as a new cardiovascular health (CVH) metric, and studies have reported associations between LE8 and CVH outcomes. However, there is ...
Beyond glucose: The crucial role of redox signaling in β-cell metabolic adaptation [0.03%]
超越葡萄糖：β细胞代谢适应中氧化还原信号的至关重要作用
Blanka Holendová,Barbora Šalovská,Štěpánka Benáková et al.
Blanka Holendová et al.
Objective: Redox signaling mediated by reversible oxidative cysteine thiol modifications is crucial for driving cellular adaptation to dynamic environmental changes, maintaining homeostasis, and ensuring proper function. ...
Heike Münzberg,Steven B Heymsfield,Hans-Rudolf Berthoud et al.
Heike Münzberg et al.
The cloning of leptin 30 years ago in 1994 was an important milestone in obesity research. Prior to the discovery of leptin, obesity was stigmatized as a condition caused by lack of character and self-control. Mutations in either leptin or ...
Fueling the fight against cancer: Exploring the impact of branched-chain amino acid catalyzation on cancer and cancer immune microenvironment [0.03%]
抗癌作战的“燃料”：支链氨基酸催化对抗癌及肿瘤免疫微环境的影响探索
Qianquan Ma,Haoyu Li,Zhihao Song et al.
Qianquan Ma et al.
Metabolism of Branched-chain amino acids (BCAAs) is essential for the nutrient necessities in mammals. Catalytic enzymes serve to direct the whole-body BCAAs oxidation which involve in the development of various metabolic disorders. The rep...
Diagnostics and omics technologies for the detection and prediction of metabolic dysfunction-associated steatotic liver disease-related malignancies [0.03%]
用于检测和预测与代谢功能障碍相关肝脂肪变性肝病相关的恶性肿瘤的诊断和组学技术
Tian Lan,Frank Tacke
Tian Lan
The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise, making it the leading etiology of chronic liver diseases and a prime cause of liver-related mortality. MASLD can progress into steatohepat...