Central NUCB2/nesfatin-1 signaling ameliorates liver steatosis through suppression of endoplasmic reticulum stress in the hypothalamus [0.03%]
中央NUCB2/nesfatin-1信号通过抑制下丘脑内质网应激改善肝脂肪变性
Yirui He,Cheng Zhang,Shaobo Wu et al.
Yirui He et al.
Background & aims: Nucleobindin-2 (NUCB2)/nesfatin-1, a signal with recognized anorexigenic and insulin-sensitizing properties in peripheral tissues, is expressed within the hypothalamus. However, the potential involvemen...
Corrigendum to "Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19" [Metabolism volume 160 (2024) 155980] [0.03%]
关于“危重型COVID-19患者肾上腺皮质类固醇生成增加和糖皮质激素反应抑制”的勘误说明[代谢杂志第160卷（2024年）155980号论文]
Tian-Zi Wen,Tian-Ran Li,Xin-Yu Chen et al.
Tian-Zi Wen et al.
Fam3a-mediated prohormone convertase switch in α-cells regulates pancreatic GLP-1 production in an Nr4a2-Foxa2-dependent manner [0.03%]
Nr4a2-Foxa2依赖的α细胞中的Fam3a介导的前激素转化酶转换调控胰腺GLP-1产生
Dandan Wang,Tianjiao Wei,Xiaona Cui et al.
Dandan Wang et al.
Background: Fam3a has been demonstrated to regulate pancreatic β-cell function and glucose homeostasis. However, the role and mechanism of Fam3a in regulating α-cell function remain unexplored. ...
Expanding diagnostic and therapeutic horizons for MASH: Comparison of the latest and conventional therapeutic approaches [0.03%]
MASH诊疗新策略：最新疗法与传统疗法的比较
Georgia Anastasiou,Konstantinos Stefanakis,Michael A Hill et al.
Georgia Anastasiou et al.
Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and reducing malignancy and chemoresistance in ovarian cancer [0.03%]
抑制ACSS2触发糖酵解抑制和核易位以激活SIRT1/ATG5/ATG2B脱乙酰化轴，促进自噬并减少卵巢癌的恶性程度和化疗耐药性
Jiang Yang,Haoyu Wang,Bingshu Li et al.
Jiang Yang et al.
Background: Metabolic reprogramming is a hallmark of cancer, characterized by a high dependence on glycolysis and an enhanced utilization of acetate as an alternative carbon source. ACSS2 is a critical regulator of acetat...
Comparative efficacy of THR-β agonists, FGF-21 analogues, GLP-1R agonists, GLP-1-based polyagonists, and Pan-PPAR agonists for MASLD: A systematic review and network meta-analysis [0.03%]
THR-β激动剂、FGF-21类似物、GLP-1受体激动剂、GLP-1多靶点激动剂和全谱PPAR激动剂治疗非酒精性脂肪性肝病/肝炎疗效的系统评价和网络 meta 分析
Ru-Tao Lin,Qin-Mei Sun,Xin Xin et al.
Ru-Tao Lin et al.
Aims: To compare the efficacy of thyroid hormone receptor beta (THR-β) agonists, fibroblast growth factor 21 (FGF-21) analogues, glucagon-like peptide-1 receptor agonists (GLP-1RAs), GLP-1-based polyagonists, and pan-per...
PDCD4 deficiency in hepatocytes exacerbates nonalcoholic steatohepatitis through enhanced MHC class II transactivator expression [0.03%]
肝细胞中PDCD4缺乏通过增强MHC II类转激活子的表达加重非酒精性steatohepatitis
Kaikai Lu,Lei He,Zizhen Guo et al.
Kaikai Lu et al.
Nonalcoholic steatohepatitis (NASH) is a primary cause of liver cirrhosis and hepatocellular carcinoma, presenting a significant and unmet medical challenge. The necessity to investigate the molecular mechanisms underlying NASH is highlight...
Membrane tension sensing formin-binding protein 1 is a neuronal nutrient stress-responsive Golgiphagy receptor [0.03%]
一种神经元营养压力响应性高尔基体自噬受体以膜张力感受器的形式存在
Smita Saha,Anirban Mandal,Akash Ranjan et al.
Smita Saha et al.
Background: Nutrient stress-responsive neuronal homeostasis relies on intricate autophagic mechanisms that modulate various organelle integrity and function. The selective autophagy of the Golgi, known as Golgiphagy, regu...
Protein kinase N1 deficiency results in upregulation of cerebral energy metabolism and is highly protective in in vivo and in vitro stroke models [0.03%]
蛋白激酶N1缺乏通过上调脑能量代谢在体内和体外的卒中模型中产生保护作用
Stephanie Zur Nedden,Motahareh S Safari,Dido Weber et al.
Stephanie Zur Nedden et al.
Background and aim: We recently identified protein kinase N1 (PKN1) as a master regulator of brain development. However, its function in the adult brain has not been clearly established. In this study, we assessed the cer...
Starvation and infection: The role of sickness-associated anorexia in metabolic adaptation during acute infection [0.03%]
饥饿与感染：厌食症在急性感染期间代谢适应中的作用
Jessy Jindal,Jennifer Hill,Jodie Harte et al.
Jessy Jindal et al.
Sickness-associated anorexia, the reduction in appetite seen during infection, is a widely conserved and well-recognized symptom of acute infection, yet there is very little understanding of its functional role in recovery. Anorexic sicknes...