Hepatocyte-specific SLC27A4 deletion ameliorates nonalcoholic fatty liver disease in mice via suppression of phosphatidylcholine-mediated PXR activation [0.03%]
肝细胞特异性SLC27A4缺失通过抑制磷脂酰胆碱介导的PXR激活改善小鼠非酒精性脂肪肝病
Chuangpeng Shen,Zhisen Pan,Wenmin Xie et al.
Chuangpeng Shen et al.
Background: The protein Solute carrier family 27 member 4 (SLC27A4) is crucial for fatty acid synthesis and β-oxidation, but its role in hepatic steatosis and nonalcoholic fatty liver disease (NAFLD) progression is not f...
1,25-Dihydroxyvitamin D3 protects against placental inflammation by suppressing NLRP3-mediated IL-1β production via Nrf2 signaling pathway in preeclampsia [0.03%]
1,25-二羟基维生素D3通过Nrf2信号通路抑制NLRP3介导的IL-1β生成保护子痫前期胎盘炎症
Xueqing Liu,Xinyu Zhang,Linlin Ma et al.
Xueqing Liu et al.
Background: Maternal vitamin D deficiency is associated with an increased risk of preeclampsia, a potentially life-threatening multi-system disorder specific to human pregnancy. Placental trophoblast dysfunction is a key ...
The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation [0.03%]
体重减轻对去脂体重、肌肉、骨骼和造血健康的影响：新兴减肥药物治疗的启示及目标肌肉质量保持的重要性
Konstantinos Stefanakis,Michail Kokkorakis,Christos S Mantzoros
Konstantinos Stefanakis
Similar to bariatric surgery, incretin receptor agonists have revolutionized the treatment of obesity, achieving up to 15-25 % weight loss in many patients, i.e., at a rate approaching that achieved with bariatric surgery. However, over 25 ...
Leptin physiology and pathophysiology in energy homeostasis, immune function, neuroendocrine regulation and bone health [0.03%]
能量稳态、免疫功能、神经内分泌调节和骨健康中的瘦素生理学和病理生理学
Konstantinos Stefanakis,Jagriti Upadhyay,Arantxa Ramirez-Cisneros et al.
Konstantinos Stefanakis et al.
Since its discovery and over the past thirty years, extensive research has significantly expanded our understanding of leptin and its diverse roles in human physiology, pathophysiology and therapeutics. A prototypical adipokine initially id...
Impaired unsaturated fatty acid elongation alters mitochondrial function and accelerates metabolic dysfunction-associated steatohepatitis progression [0.03%]
不饱和脂肪酸延长酶功能受损改变线粒体功能并加速代谢紊乱相关性肝炎的进展
Adrien Vouilloz,Thibaut Bourgeois,Marc Diedisheim et al.
Adrien Vouilloz et al.
Background and aims: Although qualitative and quantitative alterations in liver Polyunsaturated Fatty Acids (PUFAs) are observed in MASH in humans, a causal relationship of PUFAs biosynthetic pathways is yet to be clarifi...
ZBED3 exacerbates hyperglycemia by promoting hepatic gluconeogenesis through CREB signaling [0.03%]
通过CREB信号促进肝脏糖异生从而加重高血糖症：ZBED3的作用
Yuan-Yuan Luo,Chang-Shun Ruan,Fu-Zhen Zhao et al.
Yuan-Yuan Luo et al.
Background: Elevated hepatic glucose production (HGP) is a prominent manifestation of impaired hepatic glucose metabolism in individuals with diabetes. Increased hepatic gluconeogenesis plays a pivotal role in the dysregu...
CHK1 attenuates cardiac dysfunction via suppressing SIRT1-ubiquitination [0.03%]
CHK1通过抑制SIRT1泛素化来减轻心脏功能障碍
Tong-Tong Yang,Liu-Hua Zhou,Ling-Feng Gu et al.
Tong-Tong Yang et al.
Background: Mitochondrial dysfunction is linked to myocardial ischemia-reperfusion (I/R) injury. Checkpoint kinase 1 (CHK1) could facilitate cardiomyocyte proliferation, however, its role on mitochondrial function in I/R ...
NPRC promotes hepatic steatosis via USP30-mediated deubiquitination of C/EBPβ [0.03%]
NRP核心蛋白通过USP30介导的C/EBPβ去泛素化促进肝脂肪变性
Feng Jiang,Xinmiao Li,Lifan Lin et al.
Feng Jiang et al.
Background and aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic liver condition characterised by dysregulated lipid metabolism. The role of Natriuretic Peptide Receptor C (NPRC), a...
GDF-15 improves the predictive capacity of steatotic liver disease non-invasive tests for incident morbidity and mortality risk for cardio-renal-metabolic diseases and malignancies [0.03%]
GDF-15改善了肝脂肪变性疾病非侵入性检测方法对心血管-肾脏-代谢疾病和恶性肿瘤发病风险的预测能力
Michail Kokkorakis,Pytrik Folkertsma,José Castela Forte et al.
Michail Kokkorakis et al.
Background & aims: Noninvasive tools (NITs) are currently used to stratify the risk of having or developing hepatic steatosis or fibrosis. Their performance and a proteomic-enabled improvement in forecasting long-term car...
A partial loss-of-function variant (Ile191Val) of the TAS1R2 glucose receptor is associated with enhanced responses to exercise training in older adults with obesity: A translational study [0.03%]
TAS1R2葡萄糖受体的部分功能丧失变异(Ile191Val)与肥胖老年人运动训练后的改善反应有关：一项转化研究
Joan Serrano,Saki Kondo,Grace M Link et al.
Joan Serrano et al.
Background: The TAS1R2 receptor, known for its role in taste perception, has also emerged as a key regulator of muscle physiology. Previous studies have shown that genetic ablation of TAS1R2 in mice enhances muscle fitnes...