Association between the Life's essential 8 health behaviors score and all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease [0.03%]
代谢功能障碍相关肝脂肪变性疾病患者生命八大健康行为评分与全因死亡率之间的关联
Yan Han,Jing Tang,Na Wu et al.
Yan Han et al.
Background: The association between Life's Essential 8 (LE8) score and all-cause mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unknown. ...
Targeted metabolomics identified novel metabolites, predominantly phosphatidylcholines and docosahexaenoic acid-containing lipids, predictive of incident chronic kidney disease in middle-to-elderly-aged Chinese adults [0.03%]
靶向代谢组学识别出新型代谢产物，主要为磷脂酰胆碱和二十二碳六烯酸型脂质，可预测中老年人群慢性肾脏病发病风险
Ling Liu,Hao Cai,Handong Yang et al.
Ling Liu et al.
Background: Evidence is limited regarding the association of circulating metabolites with decline of kidney function, letting alone their value in prediction of development of chronic kidney disease (CKD). ...
Qi Wu,Yan Zeng,Kang Geng et al.
Qi Wu et al.
Diabetic cardiomyopathy (DCM) is the primary cause of heart failure in patients with diabetes and is characterised by contractile dysfunction and left ventricular hypertrophy. The complex pathological and physiological mechanisms underlying...
Reducing the global prevalence of cardiometabolic risk factors: a bet worth winning [0.03%]
降低全球卡代谢危险因素的流行率：一场值得赢得的比赛
Federica Fogacci,Kausik K Ray,Stephen J Nicholls et al.
Federica Fogacci et al.
Bilirubin bioconversion to urobilin in the gut-liver-kidney axis: A biomarker for insulin resistance in the Cardiovascular-Kidney-Metabolic (CKM) Syndrome [0.03%]
肠道-肝脏-肾脏轴中胆红素转化为尿胆原：心血管-肾脏-代谢（CKM）综合征中胰岛素抵抗的生物标志物
Zachary A Kipp,Olufunto O Badmus,David E Stec et al.
Zachary A Kipp et al.
The rising rates of obesity worldwide have increased the incidence of cardiovascular disease (CVD), making it the number one cause of death. Higher plasma bilirubin levels have been shown to prevent metabolic dysfunction and CVD. However, r...
An updated overview on hepatocellular carcinoma in patients with Metabolic dysfunction-Associated Steatotic Liver Disease: Trends, pathophysiology and risk-based surveillance [0.03%]
代谢功能异常相关性肝小静脉闭塞病患者的肝细胞癌最新概述：趋势、病理生理和基于风险的监测
Angelo Armandi,Chiara Rosso,Gian Paolo Caviglia et al.
Angelo Armandi et al.
Hepatocellular carcinoma (HCC) is a relevant complication occurring in individuals with advanced Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD). Recent epidemiological data suggest an alarming increase in the HCC burden wo...
Accurate non-invasive detection of MASH with fibrosis F2-F3 using a lightweight machine learning model with minimal clinical and metabolomic variables [0.03%]
基于轻量级机器学习模型的MASH伴F2-F3期肝纤维化的无创精准诊断研究（临床和代谢组变量最少）
Konstantinos Stefanakis,Geltrude Mingrone,Jacob George et al.
Konstantinos Stefanakis et al.
Background: There are no known non-invasive tests (NITs) designed for accurately detecting metabolic dysfunction-associated steatohepatitis (MASH) with liver fibrosis stages F2-F3, excluding cirrhosis-the FDA-defined rang...
Successful repurposing of empagliflozin to treat neutropenia in a severe congenital neutropenia patient with G6PC3 mutations [0.03%]
恩格列净成功用于G6PC3突变严重先天性中性粒细胞减少症患者的治疗
Grigorios Tsaknakis,Erasmia Boutakoglou,Irene Mavroudi et al.
Grigorios Tsaknakis et al.
Metabolic dysfunction-associated steatotic liver disease and urinary system cancers: Mere coincidence or reason for concern? [0.03%]
代谢功能异常相关性脂肪肝病与泌尿系统癌症：偶合关系还是值得关注？
Fernando Bril,Alicia Elbert
Fernando Bril
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a systemic disease characterized by insulin resistance and lipotoxicity. Its association with type 2 diabetes, cardiovascular disease, liver cirrhosis, and hepatocellular c...
Amir Ajoolabady,Domenico Pratico,Mohsen Mazidi et al.
Amir Ajoolabady et al.
PCSK9 is a serine protease that regulates plasma levels of low-density lipoprotein (LDL) and cholesterol by mediating the endolysosomal degradation of LDL receptor (LDLR) in the liver. When PCSK9 functions unchecked, it leads to increased d...