Disrupted metabolic flux balance between pyruvate dehydrogenase and pyruvate carboxylase in human fatty liver [0.03%]
人类脂肪肝中丙酮酸脱氢酶和丙酮酸羧化酶代谢通量紊乱
Jae Mo Park,Sung-Han Lin,Jeannie D Baxter et al.
Jae Mo Park et al.
Hepatic metabolism involving pyruvate carboxylase (PC) and pyruvate dehydrogenase (PDH) may be abnormal in fatty livers. In this study, [13C]bicarbonate production from [1-13C1]pyruvate in the liver and glycerol glyceroneogenesis were exami...
FSH exacerbates bone loss by promoting osteoclast energy metabolism through the CREB-MDH2-NAD+ axis [0.03%]
促性腺激素通过CREB-MDH2-NAD+轴促进破骨细胞能量代谢从而加重骨丢失
Jingqiu Chen,Yilin Liao,Yue Sheng et al.
Jingqiu Chen et al.
Aims: Osteoclast energy metabolism is a promising target for treating diseases characterized by high osteoclast activity, such as osteoporosis. However, the regulatory factors involved in osteoclast bioenergetic processes...
Posttranslational modifications in cardiac metabolic remodeling mediated by metabolites: Implications for disease pathology and therapeutic potential [0.03%]
心脏代谢重塑中由代谢物介导的蛋白质翻译后修饰在疾病病理和治疗潜力中的作用
Lifei Guo,Yuting Du,Heng Li et al.
Lifei Guo et al.
The nonenergy-producing or biomass-accumulating functions of metabolism are attracting increasing attention, as metabolic changes are gaining importance as discrete signaling pathways in modulating enzyme activity and gene expression. Subst...
Association between higher consumption of ultra-processed foods and risk of diabetes and its complications: A systematic review & updated meta-analysis [0.03%]
ultra-Processed食物摄入量较高与糖尿病及其并发症的风险之间的联系：系统回顾和更新的meta分析
Matheus Souza,Felipe S Moura,Luan C V Lima et al.
Matheus Souza et al.
Background & aims: Recent epidemiologic studies on the association between higher consumption of ultra-processed foods (UPF) and risk of incident diabetes have reported conflicting results in populations worldwide. We con...
TGR5 attenuates DOCA-salt hypertension through regulating histone H3K4 methylation of ENaC in the kidney [0.03%]
TGR5通过调节肾脏ENaC的组蛋白H3K4甲基化来缓解DOCA盐高血压
Long Xu,Xinyan Wu,Luosha Long et al.
Long Xu et al.
Epithelial sodium channel (ENaC), located in the collecting duct principal cells of the kidney, is responsible for the reabsorption of sodium and plays a critical role in the regulation of extracellular fluid volume and consequently blood p...
DOC2b enrichment mitigates proinflammatory cytokine-induced CXCL10 expression by attenuating IKKβ and STAT-1 signaling in human islets [0.03%]
DOC2b富集通过减弱IKKβ和STAT-1信号传导减轻人胰岛中促炎细胞因子诱导的CXCL10表达
Diti Chatterjee Bhowmick,Miwon Ahn,Supriyo Bhattacharya et al.
Diti Chatterjee Bhowmick et al.
Introduction: Type 1 diabetic human islet β-cells are deficient in double C 2 like domain beta (DOC2b) protein. Further, DOC2b protects against cytokine-induced pancreatic islet β-cell stress and apoptosis. However, the...
Adipose ZFP36 protects against diet-induced obesity and insulin resistance [0.03%]
脂肪ZFP36蛋白对抗饮食诱导的肥胖和胰岛素抵抗
Yang Hu,Jinghan Hai,Yun Ti et al.
Yang Hu et al.
Aims: Obesity, as a worldwide healthcare problem, has become more prevalent. ZFP36 is a well-known RNA-binding protein and involved in the posttranscriptional regulation of many physiological processes. Whether the adipos...
Serum miR-365b-5p/miR-222-5p as a potential diagnostic biomarker for long-term weight loss in patients with morbid obesity after bariatric surgery [0.03%]
肥胖症代谢手术后miR-365b-5p/miR-222-5p作为长期减重潜在诊断标志物的可能性研究
Virginia Mela,Flores Martín-Reyes,Wilfredo Oliva-Olivera et al.
Virginia Mela et al.
Background: The successful weight loss following bariatric surgery is not achieved in all patients with morbid obesity (MO). This study aims to determine whether a serum miRNA profile can predict this outcome. ...
PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progression [0.03%]
PPARα-ERRα信号交叉对话缓解代谢功能障碍相关性肝脂肪变性疾病进展
Milton Boaheng Antwi,Sander Lefere,Dorien Clarisse et al.
Milton Boaheng Antwi et al.
Background and aims: Metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent liver disease worldwide, continues to rise. More effective therapeutic strategies are urgently needed. We investiga...
CD36-mediated uptake of oxidized LDL induces double-negative regulatory T cell ferroptosis in metabolic dysfunction-associated steatotic liver disease [0.03%]
氧化低密度脂蛋白诱导的CD36介导的铁死亡参与代谢功能紊乱相关肝脂变和肝病发生发展过程中的Tr1细胞减少机制研究
Yunxiong Wei,Yuan Jiang,Jingjing Zhu et al.
Yunxiong Wei et al.
Background: Metabolic alterations have been shown to instigate liver inflammation in metabolic dysfunction-associated steatotic liver disease (MASLD), but the underlying mechanism is not fully elucidated. During MASLD pro...