Metabolaging: a new geroscience perspective linking aging pathologies and metabolic dysfunction [0.03%]
代谢老化：一个新的老年学视角，连接老化病理和代谢功能障碍
Fadi Khalaf,Dalia Barayan,Sean Saldanha et al.
Fadi Khalaf et al.
With age, our metabolic systems undergo significant alterations, which can lead to a cascade of adverse effects that are implicated in both metabolic disorders, such as diabetes, and in the body's ability to respond to acute stress and trau...
A systematic review & updated meta-analysis on the association between higher consumption of ultra processed foods and risk of diabetes and its complications: Response Letter [0.03%]
关于高消费超加工食品与糖尿病及其并发症风险之间关联的系统评价及更新荟萃分析：回复信
Matheus Souza,Felipe S Moura,Luan C V Lima et al.
Matheus Souza et al.
Uncovering mechanisms of thiazolidinediones on osteogenesis and adipogenesis using spatial fluxomics [0.03%]
利用空间流组学揭示噻唑烷二酮类在成骨和成脂中的作用机制
Kristyna Brejchova,Michal Rahm,Andrea Benova et al.
Kristyna Brejchova et al.
Objective: Insulin-sensitizing drugs, despite their broad use against type 2 diabetes, can adversely affect bone health, and the mechanisms underlying these side effects remain largely unclear. Here, we investigated the d...
Fructose-induced progression of steatohepatitis involves disrupting aldolase B-AMPK signaling in methionine adenosyltransferase 1A deficient mice [0.03%]
果糖通过破坏甲硫氨酸腺苷转移酶1A缺乏小鼠的醛缩酶B-AMPK信号引起肝炎的发展
Lucía Barbier-Torres,María Luque-Urbano,Jyoti Chhimwal et al.
Lucía Barbier-Torres et al.
Objective: Aldolases (ALDO) are sensors that regulate AMPK via binding to fructose 1,6-biphosphate (FBP), an intermediate of glucose and fructose metabolism. Fructose consumption is linked to metabolic dysfunction-associa...
Start small, think big: MicroRNAs in diabetes mellitus and relevant cardiorenal-liver metabolic health spectrum [0.03%]
小中见大：microRNA在糖尿病及相关心血管-肾脏-肝脏代谢健康谱系中的作用
Junren Chen,Maozhu Luo,Ziwei Xing et al.
Junren Chen et al.
Diabetes mellitus (DM), co-existing with metabolic disorder of cardio-renal-liver, is one of the most difficult problems in medicine that attracts global concern with high mortality. MicroRNAs (miRNAs) are a class of small non-coding RNA mo...
Preclinical insights into the potential of itaconate and its derivatives for liver disease therapy [0.03%]
异丁酸及其衍生物治疗肝病的潜在作用机制的临床前见解
Xiaodong Wu,Yanhong Song,Zhengwei Yuan et al.
Xiaodong Wu et al.
Annually, approximately 3.5 % of the world's population dies of cirrhosis or liver cancer, and the burden of liver disease is steadily expanding owing to multiple factors such as alcohol consumption, irrational diets, viral transmission, an...
Effects of coding variants in the glucokinase regulatory protein gene on hepatic glucose and triglyceride metabolism suggest a gene regulatory function of glucokinase [0.03%]
葡萄糖激酶调节蛋白基因的编码变异体对肝糖类和甘油三酯代谢的影响提示其具有基因调控功能
Sara Langer,David Jagdhuhn,Rica Waterstradt et al.
Sara Langer et al.
Background: Regulation of glucose metabolism after a meal is the major task of hepatic glucokinase (GCK). Inhibition and nuclear retention of glucokinase during fasting is achieved by glucokinase regulatory protein (GKRP)...
Combined loss of glyoxalase 1 and aldehyde dehydrogenase 3a1 amplifies dicarbonyl stress, impairs proteasome activity resulting in hyperglycemia and activated retinal angiogenesis [0.03%]
糖醛酸酶1和醛脱氢酶3a1联合作用加重二羰基应激，导致蛋白酶活性受损，从而引发高血糖症及视网膜血管增生过度活化
Shu Li,Hao Li,Katrin Bennewitz et al.
Shu Li et al.
Background & aims: Any energy consumption results in the generation of highly reactive dicarbonyls and the need to prevent excessive dicarbonyls accumulation through the activity of several interdependent detoxification e...
Exploring receptors for pro-resolving and non-pro-resolving mediators as therapeutic targets for sarcopenia [0.03%]
探究促resolution介质和非促resolution介质受体作为治疗肌肉减少症的靶点
Tiantian Wang,Sihan Chen,Dong Zhou et al.
Tiantian Wang et al.
Sarcopenia is defined by a reduction in both muscle strength and mass. Sarcopenia may be an inevitable component of the aging process, but it may also be accelerated by comorbidities and metabolic derangements. The underlying mechanisms con...