Complications, morbidity and mortality of nonalcoholic fatty liver disease [0.03%]
非酒精性脂肪肝病的并发症、发病率和死亡率
Alessandro Mantovani,Eleonora Scorletti,Antonella Mosca et al.
Alessandro Mantovani et al.
Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized public health problem, affecting up to a quarter of the world's adult population. The burden of NAFLD is influenced by the epidemics of obesity and type 2 diabetes melli...
Sex specific effect of ATPase inhibitory factor 1 on body weight: studies in high fat diet induced obese mice and genetic association studies in humans [0.03%]
ATP酶抑制因子1的性别差异对体重影响的研究及人类中的遗传相关性研究
So-Young Kwak,InHyeok Chung,Joon Kang et al.
So-Young Kwak et al.
Background: Based on the metabolic effect of exogenous ATPase inhibitory factor 1 (IF1) on glucose metabolism, we tested whether IF1 treatment is effective in ameliorating weight gain and whether its effects are sex speci...
Cancer causes metabolic perturbations associated with reduced insulin-stimulated glucose uptake in peripheral tissues and impaired muscle microvascular perfusion [0.03%]
癌症导致代谢紊乱，表现为外周组织葡萄糖摄取下降和肌肉微血管灌注受损
Xiuqing Han,Steffen H Raun,Michala Carlsson et al.
Xiuqing Han et al.
Background: Redirecting glucose from skeletal muscle and adipose tissue, likely benefits the tumor's energy demand to support tumor growth, as cancer patients with type 2 diabetes have 30% increased mortality rates. The a...
Twelve weeks of exenatide treatment increases [18F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males [0.03%]
十二周的艾西那肽治疗可增加非糖尿病男性棕色脂肪组织[18F]-脱氧葡萄糖摄取量，而不影响基础静息能耗氧化水平
Laura G M Janssen,Kimberly J Nahon,Katrien F M Bracké et al.
Laura G M Janssen et al.
Aims/hypothesis: Brown adipose tissue (BAT) improves energy metabolism by combusting glucose and lipids into heat. Agonism of the glucagon-like peptide-1 receptor (GLP-1R) within the central nervous system activates BAT i...
Controlled Clinical Trial
Metabolism: clinical and experimental. 2020 May:106:154167. DOI:10.1016/j.metabol.2020.154167 2020
Kasper W Ter Horst,Mireille J Serlie
Kasper W Ter Horst
Background: There is no consensus in the field regarding the optimal method for the expression of metabolic flux data, such as glucose disposal rates during hyperinsulinemic-euglycemic clamp experiments. Several normaliza...
Corrigendum to "Depletion of NAD pool contributes to impairment of endothelial progenitor cell mobilization in diabetes" [Metab Clin Exp 65 (2016) 852-862] [0.03%]
关于“糖尿病中NAD池的耗竭导致内皮祖细胞动员能力受损”的勘误[代谢临床实验第65卷（2016）852-862页]
Pei Wang,Xi Yang,Zheng Zhang et al.
Pei Wang et al.
Obeticholic acid for the treatment of nonalcoholic steatohepatitis: Expectations and concerns [0.03%]
奥贝胆酸治疗非酒精性脂肪肝病：期待与顾虑
Stergios A Polyzos,Jannis Kountouras,Christos S Mantzoros
Stergios A Polyzos
Metabolic flexibility is impaired in women who are pregnant and overweight/obese and related to insulin resistance and inflammation [0.03%]
代谢灵活性的受损与妊娠期超重或肥胖有关，并且与胰岛素抵抗和炎症相关
Rachel A Tinius,Maire M Blankenship,Karen E Furgal et al.
Rachel A Tinius et al.
Context: Maternal obesity is a significant public health concern that contributes to unfavorable outcomes such as inflammation and insulin resistance. Women with obesity may have impaired metabolic flexibility (i.e. an in...
Far-infrared radiation prevents decline in β-cell mass and function in diabetic mice via the mitochondria-mediated Sirtuin1 pathway [0.03%]
远红外辐照可通过线粒体介导的Sirtuin1通路防止糖尿病小鼠β细胞质量和功能的下降
Yung-Ho Hsu,Yen-Cheng Chen,Yu-Wei Chen et al.
Yung-Ho Hsu et al.
Insulin deficiency in type 2 diabetes mellitus (DM) involves a decline in both pancreatic β-cell mass and function. Enhancing β-cell preservation represents an important therapeutic strategy to treat type 2 DM. Far-infrared (FIR) radiatio...
Epigenetic silencing of microRNA-125b-5p promotes liver fibrosis in nonalcoholic fatty liver disease via integrin α8-mediated activation of RhoA signaling pathway [0.03%]
表观遗传沉默的microRNA-125b-5p通过整合素α8介导的RhoA信号途径促进非酒精性脂肪肝病肝纤维化
Qingxian Cai,Fengjuan Chen,Fen Xu et al.
Qingxian Cai et al.
Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases that may progress to liver fibrosis or cancer. The present study aimed to investigate the role of microRNA-125b-5p (miR...