Lysine potentiates insulin secretion via AASS-dependent catabolism and regulation of GABA content and signaling [0.03%]
鸟氨酸氨基甲酰转移酶通过AASS依赖性代谢和调节GABA含量和信号转导促进胰岛素分泌
Felipe Munoz,Qian Gao,Matthias Mattanovich et al.
Felipe Munoz et al.
Lysine is an essential amino acid with insulinotropic effects in humans. In vitro, it enhances glucose-stimulated insulin secretion (GSIS) in β-cell lines and rodent islets. While lysine is thought to act via membrane depolarization simila...
Pros and cons of different dietary patterns for the treatment of metabolic dysfunction-associated steatotic liver disease [0.03%]
不同饮食模式治疗代谢功能异常相关肝脂肪变性疾病的优势与劣势
Patrizia Palumbo,Giada Di Betto,Renata Menozzi et al.
Patrizia Palumbo et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming the most prevalent hepatic disorder, affecting up to 33 % of the global population. An altered lifestyle, characterized by extended physical inactivity and increas...
SRSF1 is essential for pancreatic β-cell proliferation and the maintenance of glucose homeostasis in mice [0.03%]
SRSF1对小鼠胰腺β细胞增殖及葡萄糖稳态维持是必不可少的
Xue You,Qian Peng,Wenju Qian et al.
Xue You et al.
Background: β-Cell proliferation is vital for adapting to metabolic stress. Failure to expand β-cell mass during insulin resistance and aging contributes to dysfunction and diabetes. Understanding the mechanisms behind ...
Angiopoietin-like protein 8 mediates inflammation and fibrosis of tubular cells in diabetic kidney disease progression by interacting with Akt2 [0.03%]
血管生成素样蛋白8通过与Akt2相互作用介导糖尿病肾病进展中管状细胞的炎症和纤维化
Limeng Pan,Yi He,Yuxi Xiang et al.
Limeng Pan et al.
Background and aims: Angiopoietin-like protein 8 (ANGPTL8), an important regulator of glucose and lipid metabolism, has recently been shown to be associated with renal function decline in patients with diabetic kidney dis...
Pancreas meets brain: β-hydroxybutyrate as a novel "β-cellular" metabolism therapy [0.03%]
胰腺与大脑的交汇点：β-羟基丁酸作为新型“β细胞代谢疗法”
Caroline Lopa,Donatella Pietrangelo,Gaetano Santulli et al.
Caroline Lopa et al.
β-hydroxybutyrate (BHB), the predominant ketone body in human circulation, is synthesized in liver mitochondria and rises markedly during fasting, caloric restriction, ketogenic diets, and high-intensity exercise. Once considered a mere me...
METTL1-mediated m7G methylation of FoxO1 regulates lipid metabolism in metabolic dysfunction-associated fatty liver disease [0.03%]
METTL1介导的FoxO1甲基化调控代谢紊乱相关脂肪肝发病机制
Jiang Du,Yujie Li,Xinxing Zhu et al.
Jiang Du et al.
Metabolic dysfunction-associated fatty liver disease (MASLD) is characterized by the accumulation and degeneration of lipids in hepatocytes, presenting a complex pathogenesis that complicates drug development. In this study, we found that m...
A melanocortin 4- and glucagon-like peptide 1 receptor multiple agonist for the treatment of diabetes and obesity [0.03%]
一种治疗糖尿病和肥胖病的MC4-和GLP-1受体激动剂
Emily F Ashlaw,Clinton T Elfers,Kylie S Chichura et al.
Emily F Ashlaw et al.
Obesity and its sequelae cause significant morbidity and mortality worldwide. Current glucagon-like peptide-1 (GLP-1) receptor agonist-based treatments have significant side-effects associated with high rates of treatment discontinuation. S...
Glucoprivation-induced nutrient preference relies on distinct NPY neurons that project to the paraventricular nucleus of the hypothalamus [0.03%]
糖饥饿诱导的营养偏好依赖于不同类型的下丘脑室旁核弓状核神经肽Y神经元
Nawarat Rattanajearakul,Kunio Kondoh,Ou Fu et al.
Nawarat Rattanajearakul et al.
Background: Neural pathways related to total calorie intake have been extensively studied. However, it remains unclear how these mechanisms control food selection. ...
NSD2 exacerbates metabolic dysfunction-associated steatotic liver disease progression by suppressing TFEB-mediated autophagy-lysosomal pathway [0.03%]
NSD2通过抑制TFEB介导的自噬溶酶体途径加重与代谢功能障碍相关的肝脂肪变性疾病进展
Yuan Qiao,Yijia Zhang,Cuiting Sun et al.
Yuan Qiao et al.
Objectives: Impaired autophagy is increasingly recognized as a key contributor to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, its underlying molecular mechanisms remain l...
Hepatic aconitase 1 redirects citrate flux to suppress lipogenesis and ameliorate hypercholesterolemia [0.03%]
肝细胞乙醇酸氧化酶1通过重定向柠檬酸流向来抑制脂质合成并改善高胆固醇血症
Linyi Li,Yu Wang,Zhiyong Du et al.
Linyi Li et al.
Background and aims: Targeting key enzymes in hepatic de novo lipogenesis (DNL) presents a promising strategy for treating hypercholesterolemia. However, the precise regulatory mechanisms governing hepatic DNL remain inco...