Apolipoprotein C-III inhibitors for the treatment of hypertriglyceridemia: A meta-analysis of randomized controlled trials [0.03%]
载脂蛋白C-III抑制剂治疗高甘油三酯血症的疗效的meta分析
Mariana de Moura de Souza,Beatriz Ximenes Mendes,Maria Luiza Rodrigues Defante et al.
Mariana de Moura de Souza et al.
Introduction: Hypertriglyceridemia is related to atherosclerotic cardiovascular risk and pancreatitis risk. The efficacy and safety of apolipoprotein C-III (APOC-III) inhibitors remains unclear. ...
Fat absorption and metabolism after Roux-en-Y gastric bypass surgery [0.03%]
Roux-en-Y胃旁路手术后的脂肪吸收与代谢
Morten Hindsø,Annemarie Lundsgaard,Bojan Marinkovic et al.
Morten Hindsø et al.
Background: Triacylglycerol (TAG) plasma excursions after a high-fat meal are blunted after Roux-en-Y gastric bypass (RYGB), but underlying mechanisms are poorly understood. We studied TAG absorption and metabolism in 12 ...
Arrestin domain containing 3 promotes alcohol-induced liver steatosis by reducing stearoyl-CoA desaturase-1 ubiquitinated degradation [0.03%]
含有 arrestin 结构域蛋白 3 通过减少硬脂酰 CoA 去饱和酶 1 的泛素降解促进酒精诱导的肝脂肪变性疾病
Ying Tang,Haoxiong Zhou,Xuemei Pan et al.
Ying Tang et al.
Background and aims: Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide with no approved therapy. The development of ALD is strongly associated with hepatic lipid accumulation. Arrestin doma...
Differential risk assessment in persons at risk of type 2 diabetes using urinary peptidomics [0.03%]
尿液肽组学在2型糖尿病风险个体中进行差异化风险评估
Anja Schork,Andreas Fritsche,Erwin D Schleicher et al.
Anja Schork et al.
Objective: Individuals at increased risk of type 2 diabetes have recently been classified into six prediabetes clusters, which stratify the risk of progression to diabetes and diabetes complications. Clusters 1, 2 and 4 a...
Dan Zhang,Yang-He Zhang,Bin Liu et al.
Dan Zhang et al.
Renal fibrosis is a pathological consequence of end-stage chronic kidney disease, driven by factors such as oxidative stress, dysregulated fatty acid metabolism, extracellular matrix (ECM) imbalance, and epithelial-to-mesenchymal transition...
Precision nutrition in aging: enhancing frailty prevention through personalized dietary interventions [0.03%]
精准营养在老龄化中的应用：通过个性化饮食干预增强脆弱性预防
Ronal Surya Aditya,Riza Amalia,Rizky Andana Pohan et al.
Ronal Surya Aditya et al.
Reply to: "Precision nutrition in aging: Enhancing frailty prevention through personalized dietary interventions" [0.03%]
《精准营养在老龄化中的应用：通过个性化膳食干预增强对脆弱状态的预防》
Rosy Conforto,Valeria Rizzo,Raffaella Russo et al.
Rosy Conforto et al.
Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia [0.03%]
小的胞外囊泡介导的AMPKα2靶向作用对脑缺血的神经保护效应
Alberto Ouro,Amanda Rodríguez-Díaz,Tania López-González et al.
Alberto Ouro et al.
Background and aims: Smoking is a known risk factor for stroke. However, the 'stroke paradox' refers to the observation that stroke patients who smoke often have higher survival rates and better outcomes compared to non-s...
Ceramides increase mitochondrial permeabilization to trigger mtDNA-dependent inflammation in astrocytes during brain ischemia [0.03%]
脑缺血时半乳糖脑苷脂增加线粒体通透性以触发星形胶质细胞中mtDNA依赖的炎症反应
Feng-Qing Huang,Hong-Fei Wang,Tong Yang et al.
Feng-Qing Huang et al.
The brain is rich in lipids, and disorders or abnormalities in lipid metabolism can induce neurotoxicity. Ceramides are the central intermediates of sphingolipid metabolism. This study was designed to investigate the potential lipotoxicity ...
IFT80 and TRPA1 cooperatively regulate bone formation by calcium signaling in response to mechanical stimuli [0.03%]
IFT80和TRPA1通过钙信号对机械刺激反应协同调节骨形成
Ting Wang,Yue Chen,Xinyi Zhu et al.
Ting Wang et al.
Background: Intraflagellar transport 80 (IFT80) is vital for primary cilia which can sense and transduce mechanical signals. Mechanical stimuli expedite osteoblastic differentiation and bone formation in mesenchymal stem ...