Syndecan-1 regulates lipid metabolism and mitigates fibrosis during the transition from acute kidney injury to chronic kidney disease [0.03%]
syndecan-1调节脂质代谢并在急性肾损伤向慢性肾病过渡期间缓解纤维化
Daoqi Shen,Liyu Lin,Yiqi Su et al.
Daoqi Shen et al.
Background: The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) is characterized by persistent renal fibrosis, in which abnormal lipid metabolism plays a crucial role. Syndecan-1 (SDC-1) has been...
Mini-review of the EAT-Lancet planetary health diet and its role in cardiometabolic disease prevention [0.03%]
“柳叶刀EAT饮食”与心血管代谢疾病预防的 mini 综述
Anna Stubbendorff,Suzanne Janzi,Juulia Jukkola et al.
Anna Stubbendorff et al.
Human diets play a crucial role in both human health and environmental sustainability. In 2019, the EAT-Lancet Commission on healthy diets from sustainable food systems introduced the EAT-Lancet planetary health diet, a universal reference ...
Exercise training increases skeletal muscle sphingomyelinases and affects mitochondrial quality control in men with type 2 diabetes [0.03%]
运动训练可增加2型糖尿病患者骨骼肌中鞘氨醇单磷酸酶的含量并影响线粒体质量控制
Mona Hendlinger,Lucia Mastrototaro,Marten Exterkate et al.
Mona Hendlinger et al.
Lipotoxic ceramides (CERs) are implicated in the development of insulin resistance, type 2 diabetes (T2D) and related complications. Exercise training improves insulin sensitivity, potentially via reducing intracellular lipids or enhancing ...
A key role of polyamine metabolism in adipose tissue homeostasis that regulates obesity [0.03%]
多胺代谢在脂肪组织稳态和肥胖调节中的关键作用
Christine Mund,Anupam Sinha,Anika Aderhold et al.
Christine Mund et al.
Background and aims: Adipose tissue function is integral to systemic metabolic homeostasis. Excessive adipose tissue growth is associated with development of chronic low-grade inflammation and whole body dysmetabolism. Th...
Symphony of regulated cell death: Unveiling therapeutic horizons in sarcopenia [0.03%]
调控性细胞死亡的交响乐：揭示治疗肌肉减少症的新视野
Jie Peng,Mi Zou,Qianmingyue Zhang et al.
Jie Peng et al.
Sarcopenia is a progressive musculoskeletal condition associated with aging, marked by a decline in muscle mass, strength, and performance. This condition not only compromises functional independence in older individuals but also contribute...
The intersection of exercise, nitric oxide, and metabolism: Unraveling the role of eNOS in skeletal muscle and beyond [0.03%]
运动、一氧化氮和代谢的交汇：解密一氧化氮合酶在骨骼肌及其他组织中的作用
Pierre-Anne R Laird,Rebecca M Wall,Siobhan M Craige
Pierre-Anne R Laird
Exercise protects against several diseases including cardiometabolic disorders. However, the molecular mechanisms driving these adaptations remain incompletely defined. Endothelial nitric oxide synthase (eNOS), a key source of nitric oxide ...
Lactiplantibacillus plantarum strain 84-3-derived l-glutamine ameliorates glucose homeostasis via AMPK/PPARγ signaling pathway activation in type 2 diabetes [0.03%]
植氏植物乳杆菌84-3株来源的l-谷氨酰胺通过激活AMPK/PPARγ信号途径改善2型糖尿病小鼠糖代谢
Tingting Liang,Tong Jiang,Zhuang Liang et al.
Tingting Liang et al.
Background: Gut microbiota and their metabolites play an essential role in type 2 diabetes (T2D). However, contributions of individual bacterial strains and their metabolites to T2D pathogenesis remain poorly understood. ...
Natural selection signatures of 65 syndromic and 8 monogenic obesity genes in 7 ethnic groups do not support the thrifty genotype hypothesis [0.03%]
65种综合征和8种单基因肥胖症在7个人群中的自然选择信号不支持节俭基因假说
Sandra El Kouche,David Meyre
Sandra El Kouche
Background: The "thrifty genotype hypothesis" states that gene variants promoting efficient fat deposition may have been advantaged by natural selection to allow human survival during famine. Nowadays, such genes are rend...
Unraveling the roles of mitochondrial sirtuins in aging-related diseases: From mechanistic insights to therapeutic strategies [0.03%]
解开线粒体长寿蛋白在衰老相关疾病中的作用机制及治疗策略
Yanyan Cao,Yan Wang,Na Zhao et al.
Yanyan Cao et al.
Mitochondrial sirtuins, including SIRT3, SIRT4, and SIRT5, play pivotal roles in maintaining mitochondrial homeostasis by regulating oxidative phosphorylation, energy metabolism, and redox balance. Dysregulation of these enzymes is closely ...
Alteration of IGF-1 bioavailability due to PAPPA2 deficiency leads to sex-specific metabolic disturbances [0.03%]
PAPPA2缺乏通过改变IGF-1的生物利用度导致性别特异性的代谢紊乱
Antonio J López-Gambero,Antonio Vargas,María Del Mar Fernández-Arjona et al.
Antonio J López-Gambero et al.
Background: The growth hormone (GH)/insulin-like growth factor (IGF-1) axis determines optimal growth and affects metabolism and energy homeostasis. Pregnancy-associated plasma protein-A2 (PAPPA2) regulates bioactive IGF-...