Reply to letter to the editor: Circadian robustness and glycemic control: From wearable data to clinical implications [0.03%]
Da Young Lee,Jung-Been Lee,Inha Jung et al.
Da Young Lee et al.
Julia Chronopoulos,George Hajishengallis,Triantafyllos Chavakis
Julia Chronopoulos
Diseases associated with obesity and metabolic dysregulation, such as diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD) promote chronic low-grade inflammation, which in turn, may enhance the risk for cardiovascul...
Proteomics and metabolomics biomarkers for predicting the onset and progression of diabetic complications: A systematic review and bioinformatics integration [0.03%]
Wei Song,Xiaoqian Nie,Zhenghong Zhu et al.
Wei Song et al.
Diabetic complications are major drivers of morbidity and mortality, leading to progressive cardiovascular, renal, retinal, and neurological damage. Early intervention is hindered by the lack of reliable biomarkers for prediction and diseas...
The heart rate paradox and inferential limits of the GLP-1 receptor agonist-atrial fibrillation association [0.03%]
Xinhui Zhan,Jiafeng Zhang
Xinhui Zhan
Large-scale plasma proteomics for predicting future cardiovascular and all-cause mortality among individuals with cardiovascular-kidney-metabolic syndrome stage 0-3 [0.03%]
Bingtao Weng,Jiahe Wei,Han Chen et al.
Bingtao Weng et al.
Background: Identifying high-risk individuals for cardiovascular and all-cause mortality among individuals with cardiovascular-kidney-metabolic (CKM) syndrome stage 0-3 can guide the implementation of targeted interventio...
SREBP2 links ACSS2-dependent acetyl-CoA biosynthesis to metaboloepigenetic activation of hepatic stellate cells and liver fibrosis [0.03%]
Yu Wang,Aoqi Kang,Shunjie Wang et al.
Yu Wang et al.
Aberrant liver fibrosis is frequently observed in and contributes to the pathogenesis of end-stage liver diseases including cirrhosis and hepatocellular carcinoma. Hepatic stellate cells (HSCs) trans-differentiate into ECM-producing myofibr...
Metabolomics profiles of type 2 diabetes and insulin resistance and their associations with total mortality [0.03%]
Jesús F García-Gavilán,Indira Paz-Graniel,Josué A Pérez-Acosta et al.
Jesús F García-Gavilán et al.
Objective: This study aimed to identify metabolomic profiles associated with type 2 diabetes and insulin resistance (HOMA-IR) and relate them to the risk of total mortality. ...
Cardiovascular health factors and altered proteomic landscapes in the progression of cardiovascular-kidney-metabolic syndrome: Evidence from multi-cohorts in China, the UK, and the US [0.03%]
基于中英美三国多队列的心肾代谢综合征演变过程中心血管健康因素与蛋白组改变：来自中国、英国和美国的证据
Erxu Xue,Jianhui Zhao,Bowen Chen et al.
Erxu Xue et al.
Background: The role of cardiovascular health (CVH) factors and their associated proteomic profiles in the progression and prognosis of cardiovascular-kidney-metabolic (CKM) syndrome among individuals at stages 0-3 remain...
Amycretin in obesity: Mechanisms, clinical efficacy, and future perspectives [0.03%]
AMYCRININE肥胖症中的作用：机制、临床疗效和未来展望
Linghua Fu,Rui Ding,Gaosi Xu et al.
Linghua Fu et al.
The global escalation of obesity necessitates therapeutic interventions that transcend the efficacy ceilings of current mono-target pharmacotherapies. Amycretin, a novel unimolecular co-agonist targeting glucagon-like peptide-1 (GLP-1) and ...
An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding [0.03%]
下颌下神经元在限时进食期间维持体温方面的作用不可或缺
Cunjin Su,Jing Cai,Yuanzhong Xu et al.
Cunjin Su et al.
Homeotherms maintain a steady body temperature through thermoregulation, a process critical for survival during fasting, in which the brain has to defend energy-costly body temperature while reducing energy expenditure to conserve energy re...