Analysis of Discordance between Mismatch Repair and Microsatellite Instability Testing in Endometrial Cancer [0.03%]
子宫内膜癌中错配修复与微卫星不稳定检测不一致的分析
Yun Xi,Chunhong He,Xianhua Fang et al.
Yun Xi et al.
Accurate molecular classification of endometrial carcinoma (EC) is critical for guiding therapy, particularly concerning mismatch repair-deficient (MMRd). However, the consistency of MMRd detection across different diagnostic modalities and...
PIK3R1 acts as a prominent biomarker for tumor immune microenvironment modulation in intravenous leiomyomatosis [0.03%]
PIK3R1在静脉平滑肌瘤病肿瘤免疫微环境调节中充当显著生物标志物
Zijuan Zhang,Penghui Feng,Zhitong Ge et al.
Zijuan Zhang et al.
Background: In current clinical practice, intravenous leiomyomatosis (IVL) can be surgically resected using either one-step or two-step approach. However, several challenges persist, including a high rate of postoperative...
Detection of Targetable Genetic Alterations in SMARCA4-Deficient Neoplasms of the Lung - Further Evidence of a Relationship Between SMARCA4-Deficient Undifferentiated Tumor and Non-Small Cell Carcinoma [0.03%]
肺SMARCA4缺陷型肿瘤中靶向基因变异的检测——进一步证明SMARCA4缺陷型未分化肿瘤与非小细胞肺癌之间的关系
Danielle D&#x;Ambrosio,Nicholas Frazzette,Matija Snuderl et al.
Danielle D&#x;Ambrosio et al.
Thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4d-UT) is an uncommon, aggressive lung neoplasm associated with smoking and characterized by loss of SMARCA4 (BRG-1) expression. Although originally considered to be a primary sarcoma...
CYP11B2 Expression Patterns in Primary Aldosteronism: Assessment Cortisol Co-secretion and the B2 Ratio Criteria [0.03%]
原发性醛固酮增多症中CYP11B2表达模式的分析：皮质醇共分泌和B2比值标准
Stanley M Chen Cardenas,Andres Matoso,Huili Li
Stanley M Chen Cardenas
Primary aldosteronism (PA) is the most common form of endocrine hypertension, with a prevalence of 5-15%. Unilateral PA accounts for approximately 30% of PA and has been associated with excellent post-operative results. Introduction of CYP1...
Genome-wide DNA methylation profiling of pleomorphic carcinoma of the lung [0.03%]
肺多形性癌的全基因组DNA甲基化谱分析
Takahiro Nakagomi,Mao Fujimoto,Shoji Kuriyama et al.
Takahiro Nakagomi et al.
The aim of this study was to clarify the significance of DNA methylation alterations in the histological and clinicopathological diversity of pleomorphic carcinoma of the lung. Eleven samples of non-cancerous lung tissue (N), and 10 and 11 ...
Quantitative assessment of cribriform intraductal carcinoma of the prostate is useful for risk stratification after radical prostatectomy [0.03%]
前列腺根治术后筛状导管内癌的定量评估有助于风险分层
Ying Wang,Hiroshi Miyamoto
Ying Wang
It remains uncertain if the extent of intraductal carcinoma of the prostate (IDC) exhibiting cribriform (Crib) morphology impacts on patient outcomes. We retrospectively analyzed long-term oncologic outcomes in 182 consecutive radical prost...
Correlation of Lymphocytic Infiltration and Degree of Pleomorphism with Tumor Mutation Burden in High-Grade Urothelial Carcinoma [0.03%]
高级别尿路上皮癌中淋巴细胞浸润和多形性程度与肿瘤突变负荷的相关性
Neslihan Kayraklioglu,Li Zhang,Chien-Kuang Cornelia Ding et al.
Neslihan Kayraklioglu et al.
Histopathological features and genomic biomarkers are integral to the management of patients with high-grade urothelial carcinoma (HGUC). Morphological features are often reflective of underlying genomic alterations. In this study, we inves...
Gene Expression Signatures of Shortened-Telomere-Associated Fibrotic Interstitial Lung Disease [0.03%]
与端粒缩短相关的间质性肺病的基因表达特征
Julia R Naso,Carlos Sosa,Lauren E Schefter et al.
Julia R Naso et al.
Shortened telomeres contribute to the pathogenesis of a subset of pulmonary fibrosis through mechanisms that remain unclear. We compared the expression of fibrosis-related genes in explanted lungs of pulmonary fibrosis patients with versus ...
Porto-sinusoidal vascular disease-like alterations in transplant liver biopsies: A clinicopathologic observation of transplant-associated portal vasculopathy [0.03%]
移植肝活检中的门脉血管病样改变：移植物血管病的临床病理观察
Binny Khandakar,Albina Joldoshova,Xuchen Zhang
Binny Khandakar
Objective: Non-cirrhotic portal hypertension (NCPH) encompasses hepatic vascular disorders without cirrhosis, now grouped under porto-sinusoidal vascular disease (PSVD). While PSVD features are well described in native li...
Immune profiling may improve risk stratification in early-stage colorectal carcinoma [0.03%]
免疫分型可能改善早期结直肠癌的风险分层
Ruben Oganesyan,Berk Kaan Aktas,Soo Hyun Lee et al.
Ruben Oganesyan et al.
Treatment decisions for pT1 colorectal cancer often rely on traditional histologic features, but these may incompletely predict metastatic risk. We evaluated whether features of the tumor immune microenvironment could enhance risk stratific...