OLIG2 is a marker of the fusion protein-driven neurodevelopmental transcriptional signature in alveolar rhabdomyosarcoma [0.03%]
OLIG2是肺泡横纹肌肉瘤融合蛋白驱动的神经发育转录特征标记物
Shyam S Raghavan,Kelly L Mooney,Andrew L Folpe et al.
Shyam S Raghavan et al.
Alveolar rhabdomyosarcoma (RMS) is associated with an underlying pathogenic translocation involving either PAX3 or PAX7 and FOXO1. The presence or absence of this fusion defines the biology and clinical behavior of this subtype of RMS and i...
Incidence of succinate dehydrogenase and fumarate hydratase-deficient renal cell carcinoma based on immunohistochemical screening with SDHA/SDHB and FH/2SC [0.03%]
基于SDHA/SDHB和FH/2SC免疫组化筛查的琥珀酸脱氢酶和苹果酸脱氢酶缺陷型肾细胞癌的发病情况
Sounak Gupta,Amy A Swanson,Ying-Bei Chen et al.
Sounak Gupta et al.
Mutations of the succinate dehydrogenase (SDHX) enzyme subunits commonly lead to a loss of function of the holoenzyme complex, and germline SDHX mutations lead to a genetic predisposition to SDH-deficient neoplasms, including renal cell car...
The coexpression of fibroblast activation protein (FAP) and basal-type markers (CK 5/6 and CD44) predicts prognosis in high-grade invasive urothelial carcinoma of the bladder [0.03%]
基底型标志物（CK 5/6 和 CD44）与成纤维活化蛋白（FAP）共表达对高级别膀胱尿路上皮癌预后的预测价值
Julio Calvete,Gorka Larrinaga,Peio Errarte et al.
Julio Calvete et al.
High-grade urothelial carcinoma (UC) of the bladder is a heterogeneous disease with dismal prognosis. Bladder tumors with basal phenotype are intrinsically aggressive, and morphological parameters that define disease staging remain main pro...
Immune checkpoint blocker-related sarcoid-like granulomatous inflammation: a rare adverse event detected in lymph node aspiration cytology of patients treated for advanced malignant melanoma [0.03%]
免疫检查点抑制剂相关类肉芽肿炎症：恶性黑色素瘤患者检出的罕见不良事件淋巴结穿刺细胞学检测中的发现
Erika F Rodriguez,Evan Lipson,Karthik Suresh et al.
Erika F Rodriguez et al.
Immune checkpoint inhibitors are a major breakthrough in the field of oncology. Targets for approved immune checkpoint inhibitors are cytotoxic T-lymphocytes-associated antigen 4 (CTLA-4) and programmed cell death receptor 1/ programmed cel...
Case Reports
Human pathology. 2019 Sep:91:69-76. DOI:10.1016/j.humpath.2019.07.001 2019
The interface reaction pattern in the skin: an integrated review of clinical and pathological features [0.03%]
皮肤界面反应模式：临床和病理特征的综合复习
Maria A Deschaine,Julia S Lehman
Maria A Deschaine
Not uncommonly, pathologists encounter biopsies displaying inflammation at the dermoepidermal junction and confronted with its numerous diagnostic possibilities. As with other inflammatory dermatoses, the correct diagnosis relies on careful...
Vascular density of histologically benign breast tissue from women with breast cancer: associations with tissue composition and tumor characteristics [0.03%]
乳腺癌女性患者良性乳腺组织的血管密度与组织成分和肿瘤特征的关系
Ashley M Fuller,Linnea T Olsson,Bentley R Midkiff et al.
Ashley M Fuller et al.
In breast tumors, it is well established that intratumoral angiogenesis is crucial for malignant progression, but little is known about the vascular characteristics of extratumoral, cancer-adjacent breast. Genome-wide transcriptional data s...
Clear cell carcinoma of the endometrium: an immunohistochemical and molecular analysis of 45 cases [0.03%]
子宫透明细胞癌的免疫组化和分子分析（45例报告）
Gian Franco Zannoni,Angela Santoro,Giuseppe Angelico et al.
Gian Franco Zannoni et al.
The aim of the present paper is to study a cohort of pure selected endometrial clear cell carcinomas (ECCCs) from an immunohistochemical and molecular perspective to provide new data about the molecular profile of this disease. In detail, 4...
Loss of nuclear localization of thyroid transcription factor 1 and adverse outcomes in papillary thyroid cancer [0.03%]
甲状腺转录因子1核定位丧失与乳头状甲状腺癌不良结局的关系
Ana Lopez-Campistrous,Aducio Thiesen,Anthony J Gill et al.
Ana Lopez-Campistrous et al.
Function of the thyroid follicular cell depends on nuclear expression of thyroid transcription factor 1 (TTF1). Regulation of this key protein regulating iodide transport is not well known, but its loss is linked to the most lethal of thyro...
Expression of L1 retrotransposon open reading frame protein 1 in gynecologic cancers [0.03%]
妇科恶性肿瘤中L1回文子开放阅读框蛋白1的表达
Zhouchunyang Xia,Dawn R Cochrane,Basile Tessier-Cloutier et al.
Zhouchunyang Xia et al.
LINE-1 (L1) retrotransposons are mobile genetic elements capable of "copy-and-pasting" their own sequences into random genomic loci, and one of the proteins it uses to achieve mobility is LINE-1 open reading frame 1 protein (L1ORF1p). L1ORF...
Pancreatobiliary-type intraductal papillary mucinous neoplasm of the pancreas may have 2 subtypes with distinct clinicopathologic and genetic features [0.03%]
胰管内乳头状黏液性肿瘤的胆胰类型可能存在两种具有不同临床病理和遗传学特征的亚型
Takashi Shimizu,Masayuki Akita,Keitaro Sofue et al.
Takashi Shimizu et al.
We recently experienced cases of pancreatobiliary-type intraductal papillary mucinous neoplasms (PB-IPMNs) with imaging features resembling pancreatic ductal adenocarcinomas (PDACs), and histologic appearance of purely pancreatobiliary morp...