Breast Myoepithelial Markers: Problems and Pitfalls for the Practicing Pathologist [0.03%]
乳腺肌上皮标记物：实用病理医师的问题和陷阱
S Emily Bachert,Elle Chapel,Stuart J Schnitt
S Emily Bachert
Immunohistochemical stains for myoepithelial cell (MEC) markers are commonly used in breast pathology to help distinguish benign and in situ lesions from invasive carcinomas. Benign and in situ lesions typically demonstrate an associated ME...
PAX5 as a Diagnostic Tool in Unconventional Acute Leukemia: Establishing Immunohistochemical Evidence of B-cell Lineage [0.03%]
PAX5在非典型急性白血病诊断中的作用：建立B细胞谱系的免疫组化证据
Ernest F Hidalgo Cedeno,Sharon Germans,Zenggang Pan et al.
Ernest F Hidalgo Cedeno et al.
Acute leukemia lineage assignment is critical for clinical management. When CD19 expression is dim by flow cytometry, it becomes challenging to meet criteria for B-lymphoblastic leukemia/lymphoma (B-ALL) or B-lineage in mixed phenotype. Whi...
Biological behavior of DCIS with or without microinvasion. Same and different [0.03%]
原位导管癌伴或不伴微侵袭的生物学行为：相同与不同之处
Lisa Scheidegger,Heike Frauchiger-Heuer,Esther Birindelli et al.
Lisa Scheidegger et al.
Background: Ductal carcinoma in situ (DCIS) is a non-invasive type of breast cancer, detected mostly due to associated calcifications. Although non-invasive and primarily treated with surgical excision, recurrence as in s...
Liang Cheng,Darrell D Davidson,Shaobo Zhang
Liang Cheng
Fluorescence in situ hybridization (FISH) is a simple, rapid, and reliable method for detecting genomic alterations relevant to a wide range of diseases, particularly neoplastic disorders, using routine surgical and cytological specimens. B...
Mixed-grade papillary urothelial carcinoma with a minor high-grade component shows a significantly worse clinical outcome than low-grade papillary urothelial carcinoma [0.03%]
低级别乳头状尿路上皮癌与混合级别乳头状尿路上皮癌（伴有少量高级别成分）的临床结局存在显著差异
William Mi,Chenxuan Zang,Jianping Zhao et al.
William Mi et al.
Grade heterogeneity is common in papillary urothelial carcinoma (PUC) of the urinary bladder. Mixed-grade PUC is generally treated as high-grade if the high-grade component accounts for ≥5 % of the tumor. However, the clinical behavior of ...
Association between p16INK4A expression and a treatment response to CDK4/6 inhibitor in advanced breast carcinoma [0.03%]
p16INK4A表达与晚期乳腺癌CDK4/6抑制剂治疗反应之间的关系
Xiao Huang,Shuko Harada,Shi Wei et al.
Xiao Huang et al.
Introduction: Endocrine therapy combined with cyclin-dependent kinase 4 and 6 inhibitors (1) has been approved for patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast c...
Emerging Molecular Therapeutic Targets in Breast Cancer: Pathologic Identification and Clinical Implications [0.03%]
乳腺癌新兴分子治疗靶点：病理识别与临床意义
Aysegul A Sahin,Hui Chen,Huang Xiao et al.
Aysegul A Sahin et al.
Breast carcinoma represents a biologically heterogeneous group of malignancies with diverse clinical behaviors, highlighting the need for robust molecular markers to support accurate diagnosis, prognosis, and therapeutic decision-making. Hi...
Invasive urothelial carcinoma with chordoid and myxoid features shows increased RAS/RAF pathway alterations [0.03%]
具有神经束带和黏液特征的侵袭性尿路上皮癌显示RAS/RAF通路改变增加
Emily Chan,Bradley A Stohr,Ankur R Sangoi et al.
Emily Chan et al.
Invasive urothelial carcinoma (UCa) with chordoid and myxoid features is an uncommon but previously described subtype of UCa composed of distinctive elongated nests and cords of tumor cells floating within a prominent myxoid stroma. The mol...
Identification of Constitutional MLH1 Methylation in MLH1-Deficient Colorectal Cancer [0.03%]
MLH1基因缺陷型结直肠癌中识别组成型MLH1甲基化
Jun Wang,Zijuan Zhang,Hangqi Liu et al.
Jun Wang et al.
Background: Constitutional MLH1 methylation (epimutation), a poorly recognized mechanism for Lynch syndrome (LS), are usually overlooked due to current screening strategy that rely on tumor MLH1 methylation as an indicati...
Impact of hormone sensitivity status on aberrant expression of CK7, CK20, CDX2, GATA3 and TTF1 in prostate cancer [0.03%]
激素敏感状态对前列腺癌中CK7、CK20、CDX2、GATA3和TTF1异常表达的影响
Qing Yin Wang,Nazim Benzerdjeb,Samuel Jaquet et al.
Qing Yin Wang et al.
Prostate cancer (PC) rarely expresses aberrant immunohistochemical markers such as CK7, CK20, CDX2, GATA3 and TTF1. This study evaluates whether expression of CK7, CK20, CDX2, GATA3 and TTF1 is increased in hormone-resistant (HR) PC compare...