Predicting HER2 amplification in breast cancers with equivocal HER2 immunohistochemistry [0.03%]
预测HER2免疫组化结果不确定的乳腺癌中的HER2基因扩增
Jennifer Den,Efstathia Polychronopoulou,Caroline Baughn et al.
Jennifer Den et al.
Accurate determination of human epidermal growth factor receptor 2 (HER2) status is essential for guiding targeted therapy in breast cancer. Immunohistochemistry (IHC) is routinely used for initial screening. Although reflex FISH testing is...
Incidental thyroid tissue in cervical lymph nodes in patients with fibrosing variant of Hashimoto thyroiditis [0.03%]
桥本甲状腺炎纤维化变异型患者的颈部淋巴结内甲状腺组织 incidentalność甲状腺组织在纤维变体桥本氏甲状腺炎患者的颈部淋巴结中出现
Michel Kmeid,Akeesha A Shah,Daniel Mettman et al.
Michel Kmeid et al.
Bland thyroid follicles are occasionally identified within cervical lymph nodes, raising the differential diagnosis of benign thyroid inclusions versus metastatic papillary thyroid carcinoma. Proposed criteria for benign thyroid inclusions ...
From the archives of MD Anderson Cancer Center: Crystal-storing histiocytosis associated with B-cell lymphoma [0.03%]
M.D.安德森癌症中心档案室报道：晶体贮积组织细胞增生症与B细胞淋巴瘤有关
Omar Al-Rusan,Qi Shen,L Jeffrey Medeiros
Omar Al-Rusan
Crystal-storing histiocytosis (CSH) is rare morphologic manifestation of disease histologically characterized by benign histiocytes, usually numerous, filled with cytoplasmic eosinophilic crystals. More than 200 cases have been reported in ...
Granulomatous inflammation in lung and lymph node specimens: A molecularly enhanced pathology-based algorithm for etiologic differential diagnosis [0.03%]
基于病理学的分子算法在鉴别导致肺和淋巴结肉芽肿性炎症病因中的作用
Min Hong,Lupeng Ji,Jiong Gao et al.
Min Hong et al.
Granulomatous inflammation is frequently encountered in lung and lymph node specimens and represents a diagnostic challenge because diverse infectious, immune-mediated, exposure-related, and neoplastic conditions may produce overlapping his...
Primary biliary cholangitis: Beyond classical histopathology - diagnostic challenges in native and transplanted livers [0.03%]
原发性胆汁性胆管炎：经典组织病理学之外——自身和移植肝脏中的诊断挑战
Ivana Juskova,Andrea Vajsova,John Jackson et al.
Ivana Juskova et al.
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterised by immune-mediated injury of small intrahepatic bile ducts, ultimately leading to progressive fibrosis, cirrhosis, and liver-related complicat...
Diagnostic concordance between bone marrow aspirate and trephine biopsy in hematological neoplasms and non-hematological marrow infiltrations [0.03%]
骨髓穿刺与活检在血液系统肿瘤及非血液系统骨髓浸润性病变中的诊断一致性分析
Esmat A El-Sharkawy,Eman Mosad,Nagwa I Okaily et al.
Esmat A El-Sharkawy et al.
Evaluating concurrent bone marrow aspirate (BMA) and trephine biopsy (BMB) specimens demonstrates significant diagnostic complementarity, reducing false-negative rates in plasma cell dyscrasias and marrow infiltrations, and proving that com...
On the current clinical applicability of artificial intelligence in pathology: An evidence-informed clinical readiness review [0.03%]
基于证据的临床准备性评估：人工智能在病理学领域的当前临床应用能力分析
Alberto M Marchevsky,Ann E Walts
Alberto M Marchevsky
The integration of artificial intelligence (AI) into pathology practice is anticipated to drive substantial advancements. Numerous AI-based applications have been reported but the extent of their current clinical applicability remains uncer...
Determinants of nucleic acid quality in formalin-fixed paraffin-embedded bladder urothelial carcinoma specimens: effects of specimen type, fixation conditions, and storage time [0.03%]
影响甲醛固定石蜡包埋膀胱尿路上皮癌标本中核酸质量的因素：标本类型、固定条件和储存时间的影响
Shu Yuguchi,Yoichiro Okubo,Rika Kasajima et al.
Shu Yuguchi et al.
Formalin-fixed paraffin-embedded (FFPE) tissue is the principal substrate for cancer genomic profiling, yet pre-analytical factors affect nucleic acid quality. In our workflow, transurethral resection (TUR) specimens of bladder urothelial c...
Penile median raphe cysts: A multicenter retrospective clinicopathological and immunohistochemical study [0.03%]
阴茎正中沟囊肿的临床病理和免疫组化特征分析多中心回顾性研究
Yishun Huang,Lixin Wang,Feng Xu et al.
Yishun Huang et al.
To investigate the clinical, histopathological, and immunohistochemical features of penile median raphe cysts and to further characterize their epithelial phenotypes and possible histogenesis. We performed a multicenter retrospective analys...
Development and clinical application of a histopathology-based pathological scoring system for IgG4-related disease [0.03%]
基于组织病理学的IgG4相关性疾病病理评分系统及其临床应用研究
Huimin Ni,Yao Xu,Guoxiang Xu et al.
Huimin Ni et al.
IgG4-related disease (IgG4-RD) diagnosis remains challenging due to subjective histopathological interpretation. This study aimed to develop and internally evaluate a quantitative pathological scoring system to improve diagnostic accuracy. ...