Immunomodulatory Role and Therapeutic Potential of HLA-DR+ Regulatory T Cells in Systemic Lupus Erythematosus [0.03%]
HLA-DR+调节性T细胞在系统性红斑狼疮中的免疫调节作用和治疗潜能
Jing Zhang,Bei Liao,Xiaobing Wang et al.
Jing Zhang et al.
Background: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple organ systems. A key element in maintaining immune tolerance and preventing autoimmunity is the role of regulatory T cel...
Adipose-Derived Mesenchymal Stem Cell Exosomes Encapsulating siIL1R2 Facilitate the Repair of DSS-Induced Intestinal Mucosal Injury [0.03%]
封装了siIL1R2的脂肪源间充质干细胞外泌体促进DSS诱导的肠黏膜损伤修复
Song Gao,Yajuan Ge,He Huang et al.
Song Gao et al.
Background: Interleukin-1 receptor 2 (IL1R2) and C-C motif chemokine receptor 2 (CCR2) as critical mediators of immune modulation and inflammation. This study aims to evaluate their functions in dextran sulfate sodium (DS...
Formononetin Alleviates the Inflammatory Response Induced by Carotid Balloon Injury in Rats via the PP2A/MAPK Axis [0.03%]
福莫酮通过PP2A / MAPK途径缓解由颈动脉球囊损伤引起的大鼠炎症反应
Huanli Zhao,Xuejun Wu,Shumeng Yang et al.
Huanli Zhao et al.
Background: Carotid arteriosclerosis is common, with interventional therapy being the primary treatment. However, postoperative restenosis and poor stent patency, related to vascular inflammation involving MAPK and PP2A, ...
Emily Ariail,Benjamin Biggs,Rowan O&#x;Flanagan et al.
Emily Ariail et al.
Background: IL-7 is a cytokine that plays a critical role in the development and proliferation of many different immune cells. IL-7 is notably important for the proper development and activity of T cells and B cells. Addi...
Role of TAK-242-Induced Histone Lactylation in Modulating Repair Macrophage Transformation in Ulcerative Colitis [0.03%]
TAK-242诱导的组蛋白乳酸化在溃疡性结肠炎修复巨噬细胞转化中的作用
Chenfei Zhang,Xiaoling Huang
Chenfei Zhang
Background: Ulcerative Colitis (UC) is a condition that causes ulceration and inflammation of the intestinal epithelium. UC treatment depends on macrophages' phenotypic switch from pro-inflammatory (M1) to anti-inflammato...
Variable Lymphocyte Receptor B Technologies - Are They Ready for Prime Time? [0.03%]
可变淋巴细胞受体B技术-它们准备好大显身手了吗？
Arundhati G Nair,Götz R A Ehrhardt,Eyal Grunebaum
Arundhati G Nair
Objective: To review the current and the potential research and clinical use of VLRBs. Methods: A literature search was conducted for E...
Renal Tubular Epithelial Cell-Derived IL-7 Drives Expansion and Protective Effects of Double-Negative T Cells in Acute Kidney Injury [0.03%]
急性肾损伤中肾小管上皮细胞衍生的IL-7促进双阴性T细胞增殖并发挥保护作用
Mohanraj Sadasivam,Sanjeev Noel,Kyungho Lee et al.
Mohanraj Sadasivam et al.
Background: Previous studies have demonstrated that double-negative (DN) αβ T cells play an important role in immune responses during ischemic acute kidney injury (AKI). Here, we investigate the role of γ-chain cytokin...
Superloaded Multiplexed scRNA-seq Data Preserves Primary Immune Cell Heterogeneity but Necessitates Stringent Doublet Removal [0.03%]
超加载的多重scRNAseq数据保留了初级免疫细胞的异质性但需要严格去除双阳性细胞
Henry Sserwadda,Jung Ho Lee,Brian H Lee et al.
Henry Sserwadda et al.
Background: Single-cell RNA sequencing (scRNA-seq) has improved our ability to characterize rare cell populations. In practice, cells from different tissues or donors are simultaneously loaded onto the instrument (multipl...
Application of the Monoclonal Autoantibody and Its Target Protein Derived from the Peripheral Blood of SLE Patients in Serological Diagnosis and Differential Diagnosis of SLE [0.03%]
系统性红斑狼疮患者外周血来源单克隆自免抗体及其靶蛋白的鉴定及在SLE免疫诊断和鉴别诊断中的应用研究
Keting Jin,Yalun Chen,Yuyang Ye et al.
Keting Jin et al.
Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with limited reliable diagnostic biomarkers. This study evaluates the utility of DEAD-box helicase 5 (DDX5) as a diagnostic and differentia...
Tissue-Resident Memory T Cells in Tumor Immunity and Immunotherapy of Digestive System Tumors [0.03%]
消化系统肿瘤免疫和免疫治疗中的组织驻留记忆T细胞
Min Cheng,Jie Liu,Yue Liang et al.
Min Cheng et al.
Background: Tissue-resident memory T (TRM) cells possess unique abilities to migrate, establish themselves in tissues, and monitor peripheral tissues without circulating. They are crucial in providing long-lasting and local immune protectio...