Unveiling the Role of Sdc4+ Monocytes in NASH: A Single-Cell RNA Sequencing Study [0.03%]
Sdc4+单核细胞在非酒精性脂肪性肝炎中的作用：单细胞RNA测序研究
Jing-Ze Li,Ting Mao,Yu-Xuan Gao et al.
Jing-Ze Li et al.
Background: Nonalcoholic steatohepatitis (NASH) involves liver inflammation and fibrosis. Monocytes, key immune cells differentiating into macrophages and dendritic cells, are understudied in NASH using single-cell RNA se...
Exploring the IL-21/IL-21R Signaling Pathway in Rheumatoid Arthritis: Implications for Synoviocyte Survival and Disease Progression [0.03%]
白细胞介素-21/白细胞介素-21受体信号通路在类风湿关节炎中的作用：滑膜细胞存活和疾病进展的影响
Qiuhua Chen,Shuntao Lin,Sijie Wang et al.
Qiuhua Chen et al.
Introduction: The persistent presence of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) contributes significantly to joint damage, yet the anti-apoptotic mechanisms involved are not well understood. This ...
Engineering TAG-72 and CD30 CAR-T Cells for T Cell Malignancies [0.03%]
工程化靶向TAG-72和CD30的CAR-T细胞治疗T细胞肿瘤
Van To,Vera J Evtimov,Runzhe Shu et al.
Van To et al.
Background: T cell malignancies represent a broad, highly heterogeneous subset of lymphomas with poor prognosis. Chimeric antigen receptor (CAR)-T cell therapy holds great promise in treating B cell lymphoma and multiple ...
Protective Effects of Pachymic Acid in a DSS-Induced Mouse Model of Ulcerative Colitis [0.03%]
鹅膏蕈氨酸对溃疡性结肠炎小鼠模型的保护作用
Hua Zhang,Yunxia Wu,Siyu Li et al.
Hua Zhang et al.
Objective: This study aimed to investigate the protective effects and underlying mechanisms of pachymic acid (PA), a natural triterpenoid compound, in a dextran sulfate sodium (DSS)-induced murine model of ulcerative coli...
TIM-3 in Prostate Health: A Crucial Factor in the Microbiome-Immune Balance [0.03%]
TIM-3在前列腺健康中的作用：微生物组-免疫平衡的关键因素
Elmira Davasaz Tabrizi,Mazdak Ganjalikhani Hakemi
Elmira Davasaz Tabrizi
This review highlights the emerging role of the immune checkpoint receptor T cell immunoglobulin and mucin-domain containing-3 (TIM-3) as a crucial modulator in the prostate's microbiome-immune axis, with significant implications for prosta...
Regulatory T Cells in Colon Cancer: Implications for Pathogenesis, Prognosis and Emerging Therapeutic Strategies [0.03%]
结肠癌中的调节性T细胞：对发病机制、预后和治疗策略的影响
Faris Anad Muhammad,Abdulkareem Shareef,S Renuka Jyothi et al.
Faris Anad Muhammad et al.
Introduction: Colon cancer is a highly heterogeneous malignancy with significant global incidence and mortality. The tumor microenvironment (TME) plays a pivotal role in disease progression and treatment response. Among k...
Differential Methylation Patterns Predict HBsAg Seroconversion in Hepatitis B Virus Reactivation Patients [0.03%]
差异甲基化模式可预测乙肝病毒再激活患者的乙型肝炎表面抗原血清学转换
Jayesh Kumar Sevak,Mojahidul Islam,Gayantika Verma et al.
Jayesh Kumar Sevak et al.
Background: Hepatitis B virus (HBV) modulates immune epigenetic landscape. Therefore, we investigated immune epigenetic landscape in HBsAg seroconverters and non-seroconverters. ...
Mengtao Wang,Zhicheng Cao,Wenhui Hu et al.
Mengtao Wang et al.
Background: Osteoblasts, derived from mesenchymal stem cells (MSCs) in the bone marrow, are responsible for bone formation. Osteoblast differentiation is orchestrated by a spectrum of biological signals, with immune-derived components servi...
Association between UBQLN Family Gene and Systemic Lupus Erythematosus: A Case Control Study [0.03%]
UBQLN家族基因与系统性红斑狼疮的相关性：一项病例对照研究
Qing Wu,Yong Liu,Xinyi Zhao et al.
Qing Wu et al.
Objective: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder. This study aims to investigate the association between UBQLN family genes and the systemic lupus erythematosus (SLE). ...
M2 Polarization of RAW264.7-Derived Exosomes Inhibits Osteoclast Differentiation and Inflammation via PKM2/HIF-1α Axis [0.03%]
RAW264.7衍生的外泌体M2极化通过PKM2/HIF-1α轴抑制破骨细胞分化和炎症
Yue Zhang,Yufu Liang,Yue Zhou
Yue Zhang
Background: Periodontitis (PD) is a chronic inflammatory disease characterized by alveolar bone loss, primarily driven by excessive osteoclast differentiation and activation. Exosomes derived from M2 macrophages have been...