Jie Jiang,Zongqiang Hu,Li Li
Jie Jiang
Background: Tetrahydrobiopterin (BH₄) maintains nitric oxide synthase (NOS) coupling. However, its therapeutic potential in non-alcoholic fatty liver disease (NAFLD) remains unexplored. ...
Profiling of Epstein-Barr Virus microRNAs in Whole Blood and Exosomes in Multiple Sclerosis [0.03%]
多发性硬化症外周血及外泌体EB病毒微小RNA的谱型分析
Victoria Hyslop Hvalkof,Anna Gabriella Stenvig Olsson,Stefan Gustavsen et al.
Victoria Hyslop Hvalkof et al.
Background: Multiple sclerosis (MS) is a neuroinflammatory, demyelinating disease with Epstein-Barr virus (EBV) suggested as a prerequisite for disease development. EBV expresses 44 microRNAs (miRNAs) with largely unknown...
Myelin-Reactive TCR/IgM Dual-Expresser Lymphocytes in Multiple Sclerosis: Linking Pathogenesis to Anti-CD20 Therapy [0.03%]
多发性硬化症中的髓鞘反应性TCR/IgM双重表达淋巴细胞：连接发病机制与抗CD20治疗
Prajita Paul,Marjan Behzadirad,Rafid Al Hallaf et al.
Prajita Paul et al.
Background: Multiple sclerosis (MS) is an autoimmune disorder driven by myelin autoantigen-specific autoreactive T cells, yet the most effective disease-modifying therapies (DMTs) target B cells. The mechanism underlying ...
TCR/BCR Secondary Rearrangement in Autoimmune Diseases: Molecular Mechanisms, Pathogenic Roles, and Therapeutic Frontiers [0.03%]
自身免疫病中TCR/BCR的再次重排：分子机制、致病作用及治疗前景
Fei Yang,Biao Zhang,Yi Liu et al.
Fei Yang et al.
Autoimmune diseases (AIDs) constitute a group of disorders where the immune system mistakenly attacks the body's tissues. The pathogenesis of AIDs involve a breakdown in immune tolerance, culminating in an immune response that targets autoa...
Molecular Mechanism of Butyrate Modulating Treg/Th17 Balance in UC Through cAMP-PKA/mTOR Axis [0.03%]
丁酸通过cAMP-PKA/mTOR轴调节UC中Treg/Th17平衡的分子机制研究
Minhao Li,Tinglong Wang,Mei Yuan
Minhao Li
Objective: This study aims to elucidate how butyrate, a short-chain fatty acid, regulates the Treg/Th17 balance in ulcerative colitis (UC) via the cAMP-PKA/mTOR signaling pathway, offering novel treatment strategies. ...
Lulu Zhang,Bo Tu,Qingliang Xue
Lulu Zhang
Background: Pulmonary neuroendocrine cells (PNECs) are specialized airway epithelial cells with dual sensory and secretory functions. They release bioactive mediators --including neuropeptides such as calcitonin gene-rela...
Biased Usage of V/D/J Genes and Clonal Diversity in IgG Repertoires Correlates with Disease Activity and Clinical Features in Systemic Autoimmune Diseases [0.03%]
免疫球蛋白基因偏用和克隆型多态性与自身免疫性疾病疾病活动度及临床特征相关性研究
Qian Wang,Delong Feng,Yang Song et al.
Qian Wang et al.
Objective: To examine whether features of the B cell receptor (BCR) IgG repertoire correlate with disease activity and clinical phenotypes in systemic autoimmune diseases (SAIDs). ...
The Dichotomous Role of Tertiary Lymphoid Structures in Hepatocellular Carcinoma: From Spatial Location to Clinical Implications [0.03%]
肝细胞癌中三级淋巴结构的双重作用：从空间定位到临床意义
Jingyi Xu,Yunzhang Cheng,Yilin Wang et al.
Jingyi Xu et al.
Background: Tertiary lymphoid structures (TLSs) function as ectopic immune centers in non-lymphoid tissues and are a key area of research in tumor immunology, particularly in hepatocellular carcinoma (HCC). However, the r...
Interleukin-33 in the Regulation of Autophagy and Apoptosis in Macrophages During Infection [0.03%]
感染过程中巨噬细胞中IL-33在自噬和凋亡调节中的作用
Ahmet Alperen Palabiyik,Esra Palabiyik
Ahmet Alperen Palabiyik
Introduction: Interleukin-33 (IL-33) is a multifunctional cytokine from the interleukin-1 family that plays a pivotal role in modulating macrophage responses during infection. Functioning both as an extracellular alarmin and as a nuclear tr...
Induction Condition Optimization of the M-CSF-Induced Mouse Bone Marrow-Derived Macrophage and the Mechanism Exploration Based on RNA-Seq Analysis [0.03%]
基于RNA测序分析的M-CSF诱导的小鼠骨髓来源巨噬细胞的优化及机制探讨
Liu Shen,Tingjie Ye,Wei Xu et al.
Liu Shen et al.
Background: Bone marrow-derived macrophage (BMDM) is key tool cell for studying biological processes such as immunity and inflammation. It is also known as a cell drug that can be used for cytotherapy of many diseases suc...