The Role of Myeloid-Derived Suppressor Cell (MDSC) in Fungal Infections and Its Potential as a Therapeutic Target [0.03%]
髓源性抑制细胞在真菌感染中的作用及其作为治疗靶点的潜力
Mahdi Ghasempour,Parisa Zafari
Mahdi Ghasempour
Background: The interaction between the immune system and fungi has long intrigued researchers, as fungi are among the most common organisms encountered by humans. Myeloid-derived suppressor cells (MDSCs) are specialized ...
Formulation and In-Vivo Evaluation of Aceclofenac and Quercetin Nanoemulsion-Based Gel Against Rheumatoid Arthritis [0.03%]
一种治疗类风湿性关节炎的依托芬那酯和芸芸酚纳米乳凝胶及其药代动力学性质评估研究
Prabha Singh,Jenny Shah,Prachi Pimple
Prabha Singh
Background: Rheumatoid arthritis (RA) is a chronic inflammatory, T cell-mediated autoimmune disorder which commonly affects the tiny joints of the hands and feet. ...
Emerging Insights into TIM-3: A Potential Immune Checkpoint for Lung Cancer Immunotherapeutic Strategies [0.03%]
肺癌免疫治疗策略中TIM-3的作用机制及其作为新的免疫抑制靶点的潜力初探
Omer Qutaiba B Allela,Abdulkareem Shareef,Ashok Kumar Bishoyi et al.
Omer Qutaiba B Allela et al.
Background: Recent advancements in cancer therapy have focused on blocking immune checkpoint receptors (ICRs) to restore anti-tumor immunity. Despite these developments, a significant proportion of patients remain unrespo...
Autophagy Sustained the Activation and Survival of Liver-infiltrating CD8+ T Cells in Primary Biliary Cholangitis [0.03%]
自噬维持胆汁性肝硬化中浸润的CD8⁺T细胞的激活和存活
Jie Li,Miao He,Jianguo Zhang et al.
Jie Li et al.
Background: Primary biliary cholangitis (PBC) fundamentally manifests as an immune-mediated disorder where T cell-driven autoreactivity persists as the principal pathogenic mechanism. Despite this understanding, immunosup...
Zixu Wang,Xiaoxi Dai,Hong Shu et al.
Zixu Wang et al.
Background: The skin contains a complex immune network involving keratinocytes, Langerhans cells, tissue-resident memory T cells, regulatory T cells, and B cells that collectively maintain immune surveillance and homeosta...
NLRP12 Mediates Macrophage Polarization and Drives Host Defense Against Severe Klebsiella Pneumoniae Pneumonia [0.03%]
NLRP12介导巨噬细胞极化并促进宿主抵抗严重的大肠克雷伯菌肺炎防御作用
Shunjin Zhao,Xiaoyi Tong,Qi Long et al.
Shunjin Zhao et al.
Background: Klebsiella pneumoniae (Kp) is a bacterial pathogen that results in diverse infections. NLRP12, one of the NLR family members, acts as an inflammasome in response to specific infections. Herein, the role and me...
Immunotherapy Strategies for Systemic Lupus Erythematosus: Focusing on CAR-T Cell Therapy [0.03%]
系统性红斑狼疮的免疫治疗策略：聚焦CAR-T细胞治疗
Miao Tu,Wan Liu,Yujiao Wei et al.
Miao Tu et al.
Introduction: Systemic Lupus Erythematosus (SLE) is an incurable autoimmune disease. The remarkable success of Chimeric Antigen Receptor T-cell (CAR-T) therapy in oncology has prompted its investigation for autoimmune con...
Cathepsin K (CTSK) in Inflammatory and Immune-Mediated Diseases [0.03%]
猫溶酶体蛋白酶K（CTSK）在炎症和自身免疫性疾病中的作用
Shiqi Lin,Tao Wang,Changjing Zuo
Shiqi Lin
Introduction: Cathepsin K (CTSK) is a lysosomal cysteine protease of the papain superfamily. The enzyme plays a key role in bone homeostasis. Immune cells such as dendritic cells, macrophages, and T cells all express CTSK...
Analysis of the Epigenetic State of the Dm Element within the Igκ Locus in Pre-B Cells [0.03%]
小鼠预B细胞中IGκ基因座DM元件的表观遗传状态分析
Caijun Wu,Yanying Dong,Wen Zhou et al.
Caijun Wu et al.
Background: The Igκ locus undergoes multiple molecular processes during B cell development, including V(D)J recombination and epigenetic regulation, which are influenced by cis-regulatory regions within the locus. A nove...
PD-1/TIM-3-Expressing Myeloid Cells During the Early Immune Reconstitution in Patients with Multiple Myeloma After High-Dose Chemotherapy [0.03%]
高剂量化疗后多发性骨髓瘤患者早期免疫重建过程中髓系细胞上PD-1/TIM-3的表达
Polina A Serpeninova,Tamara V Tyrinova,Egor V Batorov et al.
Polina A Serpeninova et al.
Background: In multiple myeloma (MM), immune checkpoint blockade is being explored as a treatment strategy. However, the role of inhibitory checkpoint receptors on myeloid cells remains poorly understood. The aim of our s...