High-Fat Diet Promotes Tumor Immune Evasion via CD155 Upregulation in Colorectal Cancer [0.03%]
高脂肪饮食通过上调结直肠癌中的CD155促进肿瘤免疫逃逸
Liwei Liu,Ling Mo,Jingcun Fang et al.
Liwei Liu et al.
Background: Obesity-induced metabolic stress impairs the efficacy of immune checkpoint blockade (ICB) therapy, but the mechanisms linking a high-fat diet (HFD) to immune suppression remain unclear. ...
OPN Promotes Hepatocellular Carcinoma Progression Through the p65/c-Myc/CD155 Axis by Suppressing CD8+ T Cell Infiltration and Activation [0.03%]
通过抑制CD8+T细胞浸润和活化，OPN通过p65/c-Myc/CD155轴促进肝癌进展
Jincun Fang,Liwei Liu,Zhiying He et al.
Jincun Fang et al.
Introduction: The immunosuppressive microenvironment of hepatocellular carcinoma (HCC) is shaped by multiple oncogenic pathways, but howosteopontin (OPN), a molecule frequently overexpressed in HCC, regulates anti-tumor i...
The Therapeutic Targeting Effect of Toll-Like Receptors and Their Related Signaling Pathways in Cardiomyopathy [0.03%]
toll样受体及其相关信号通路在心肌病治疗靶向作用的效果分析
Haoran Cheng,Jieqi Wang,Wang Ting
Haoran Cheng
Background: Cardiomyopathies contribute substantially to heart failure, arrhythmias, and sudden cardiac death. Innate immune activation-particularly via Toll-like receptors (TLRs)-is increasingly recognized as a driver of...
Zhaolong Yu,Songzhi Jin,Shujing Wan et al.
Zhaolong Yu et al.
Background: This review aims to synthesize the structural and functional characteristics of DOCK2, as well as its mechanistic roles in various diseases, in order to provide a theoretical foundation for targeted therapies....
Phillyrin Ameliorates Traumatic Spinal Cord Injury by Inhibiting Inflammation, Oxidative Stress, and Pyroptosis Through Modulation of the Nrf2/HO-1 Signaling Pathway [0.03%]
Phillyrin通过调节Nrf2/HO-1信号通路抑制炎症、氧化应激和细胞焦亡改善脊髓损伤
Yang Gao,Yanyang Wang,Liumin Bai et al.
Yang Gao et al.
Background: Treating traumatic spinal cord injury (SCI) requires mitigating microglia-mediated inflammation and nerve damage. Phillyrin (phi) shows neuroprotective potential, but its effects on SCI are unknown. We investi...
Microbiome Mediated Immune Crosstalk on the Gut-Thyroid Axis in Autoimmune Thyroid Disease [0.03%]
自身免疫性甲状腺疾病的肠道-甲状腺轴间菌群介导的免疫互作
Mubeen Hussein Arawker,Fitrat Habibullah,Shantanu Baral et al.
Mubeen Hussein Arawker et al.
Background: The gut microbiota plays an important role in systemic immune homeostasis and is increasingly implicated in autoimmune thyroid disease (AITD). Evidence suggests that gut dysbiosis, impaired intestinal barrier ...
The Role of IL-12 Family Cytokines in the Pathogenesis of Periodontal Disease: A Therapeutic Approach [0.03%]
白细胞介素-12家族细胞因子在牙周病发病机制中的作用及治疗潜力
Haichao Wang,Hongyi Zhang
Haichao Wang
Background: Periodontal disease is a prevalent chronic inflammatory condition of the tooth-supporting tissues characterized by progressive loss of connective attachment and alveolar bone. The IL-12 cytokine family-compris...
Journey of B Cell Dysregulation in Rheumatoid Arthritis: Insights from Immunogenomics [0.03%]
免疫组学视角下的类风湿关节炎患者B细胞失调机制探究
Kabeer Haneef,Muhammad Saleem Iqbal Khan,Muhammad Umer Asghar et al.
Kabeer Haneef et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune manifestation characterized by persistent chronic inflammation and joint damage. B cells play pivotal roles in the immune system, recognize antigens, and facil...
Type 2 Inflammatory Phenotypes in Chronic Obstructive Pulmonary Disease and Asthma: Similarities and Differences [0.03%]
慢性阻塞性肺疾病和哮喘中的2型炎症表型：相似点与不同点
Shenghan Gao,Xiaoju Liu
Shenghan Gao
Background: Asthma and chronic obstructive pulmonary disease (COPD) - two common airway diseases - have drawn greater attention lately because of their increasing occurrence and mortality rates. The main inflammatory type...
Sepsis Circulating Extracellular Vesicles: Associated Cytokine Profile, Cellular Proliferation, and Cytoprotective Activity Against Lipopolysaccharide-Induced Cytotoxicity [0.03%]
脓毒症循环细胞外囊泡：相关细胞因子谱、细胞增殖和对抗脂多糖诱导的细胞毒性作用的细胞保护活性
Usri H Ibrahim,Kwanele Xulu,Roushka Bhagwan Valjee et al.
Usri H Ibrahim et al.
Background: Extracellular vesicles (EVs) have been linked with cytokine transportation and shown promising therapeutic and diagnostic potential in sepsis. Therefore, this study investigates the levels of cytokines associa...