Immune Checkpoints in Sepsis and the Path Toward Precision Immunotherapy [0.03%]
脓毒症中的免疫检查点及精准免疫治疗之路
Bilal Abbas,Arshad Abbas,Iqbal Nawaz Khan
Bilal Abbas
Background/objective: Sepsis remains a leading cause of mortality worldwide, with immune dysfunction serving as a central driver of adverse outcomes. While early hyperinflammation contributes to organ damage, subsequent i...
Immunosuppressive Pulse Therapy Alleviates Ocular Surface Damage in Thyroid-Associated Ophthalmopathy by Reversing FGA Deficiency Subsequently Modulating Complement and Coagulation Cascade Signaling to Suppress Orbital Fibroblast Pathology [0.03%]
免疫抑制脉冲疗法通过逆转FGA缺乏从而调控补体和凝血级联信号来抑制眼眶成纤维细胞病理，缓解甲状腺相关性眼病的眼表损伤
Xiaoqing Zhou,Qian Sha
Xiaoqing Zhou
Background: Thyroid-associated ophthalmopathy (TAO)is a common autoimmune inflammatory disorder that compromises visual function and quality of life. It is characterized by orbital tissue inflammation and ocular surface i...
CD36-Mediated Fatty Acid Oxidation in CTCs Drives Immune Evasion and Metastasis in NSCLC [0.03%]
NSCLC中CD36介导的CTC脂肪酸氧化促进免疫逃逸和转移
Huizhen Zhu,Shuiyan Dai,Fengping Wang et al.
Huizhen Zhu et al.
Background: Immune checkpoint inhibitors (ICIs) show clinical benefit in subsets of non-small cell lung cancer (NSCLC) patients, yet resistance remains a major challenge. Circulating tumor cells (CTCs) contribute to tumor...
"Targeting the Body Itself": Research Progress on the Anti-Inflammatory and Immunomodulatory Mechanisms of Traditional Chinese Medicine Based on Pyroptosis Theory [0.03%]
“针对机体自身”研究基于细胞炎性焦亡理论的传统药抗炎及免疫调节机制进展
Xiaobing Ma,Peihui Han,Kanghong He et al.
Xiaobing Ma et al.
Background: Pyroptosis is a highly inflammatory form of regulated cell death executed by gasdermin proteins. It promotes the release of interleukin (IL)-1β and IL-18 to support host defense, yet its dysregulation contrib...
Yanling Zhang,Nan Li,Yachao Li
Yanling Zhang
Background: Organ transplantation faces challenges of chronic rejection and infection due to immunosuppression. Inducing long-term immune tolerance is a key goal, with anti-CD45RB antibody being a studied target for decad...
Propofol Inhibits HIF-1α/NLRP3 Signaling Pathway and Mast Cell Activation to Ameliorate Airway Inflammation in Allergic Asthma [0.03%]
丙泊酚通过抑制HIF-1α/NLRP3信号通路及肥大细胞活化改善过敏性哮喘气道炎症
Yuzhu Zhang,Jiangling Xia,Xiaona An et al.
Yuzhu Zhang et al.
Background: The objective was to assess the effects of propofol on ovalbumin (OVA)-induced asthma in a mouse model and the efficacy of propofol in stabilizing mast cells and inhibiting the production of inflammatory media...
Correction [0.03%]
改正通知书
Published Erratum
Immunological investigations. 2026 Jan 22:i. DOI:10.1080/08820139.2026.2619328 2026
Exosomal miR-451a Derived from Bone Marrow Mesenchymal Stem Cells Inhibits Macrophage M1 Polarization Through the MIF/CD74 Signaling Pathway to Alleviate Acute Lung Injury [0.03%]
骨髓间充质干细胞衍生的外泌体miR-451a通过MIF/CD74信号通路抑制M1型巨噬细胞极化从而缓解急性肺损伤
Lisi Luo,Wensha Nie,Ji Wang et al.
Lisi Luo et al.
Background: Macrophage polarization is widely involved in the progression of acute lung injury (ALI). Bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) have been reported to participate ininflammatory disease...
PTBP1-TRAF6 Axis Aggravates Chronic Obstructive Pulmonary Disease by Promoting M1 Macrophage Polarization and Impairing Clearance of Neutrophil Extracellular Traps [0.03%]
PTBP1-TRAF6轴通过促进M1型巨噬细胞极化和破坏中性粒细胞胞外陷阱的清除从而加重慢性阻塞性肺疾病
Mingming Zhao,Liangfeng Yang,Shanshan Xu et al.
Mingming Zhao et al.
Objective: To elucidate the role of the polypyrimidine tract-binding protein 1 (PTBP1)-tumor necrosis factor receptor-associated factor 6 (TRAF6) pathway in chronic obstructive pulmonary disease (COPD), with a particular ...
Emerging Immunotherapeutic Approaches in Colorectal Cancer: From Checkpoint Inhibitors to CAR-T Cell and Viral Vector Vaccines [0.03%]
结直肠癌的新兴免疫治疗策略：从检查点抑制剂到CAR-T细胞和病毒载体疫苗
Rajeev Ranjan,Amit Kumar,Vikas Kumar et al.
Rajeev Ranjan et al.
Introduction: Colorectal Cancer has been a significant health issue at a global level in terms of increasing incidence, high metastatic capacity, and inadequate treatment reactions in most patient groups. Though chemother...