Protein kinase C overexpression does not enhance immune-stimulatory surface markers of vaccinia-infected dendritic cells and DC cell lines [0.03%]
蛋白激酶C的过度表达不会增强痘病毒感染的树突细胞和DC细胞系的免疫刺激表面标记物
Hartwig P Huemer,Markus Geiger,Wilfried Posch et al.
Hartwig P Huemer et al.
One of the shortcomings of vaccinia virus (VACV) as immunization vector is the down-regulation of HLA and costimulatory molecules in antigen presenting cells. To overcome this problem we investigated the use of protein kinase C (PKC) as imm...
IL-17 gene polymorphism is associated with chronic periodontitis and peri-implantitis in Iranian patients: a cross-sectional study [0.03%]
伊朗患者中白细胞介素-17基因多态性与慢性牙周炎和种植体周围炎的相关性研究：横断面研究
Mahdi Kadkhodazadeh,Zahra Baghani,Ahmad Reza Ebadian et al.
Mahdi Kadkhodazadeh et al.
Periodontal disease (PD) and peri-implantitis (PI) are characterized by an immune response leading to destructive inflammation. The prominent impact of genetic factors on periodontitis has been previously evaluated and IL-17 has found to pl...
Improvement of HBsAg gene-modified dendritic cell-based vaccine efficacy by optimizing immunization method or the application of β-glucosylceramide [0.03%]
通过优化免疫方法或使用β- glucosylceramide改进HBsAg基因修饰树突状细胞疫苗的效果
Jianting Long,Bo Zhou,Heping Li et al.
Jianting Long et al.
Hepatocellular carcinoma (HCC) in China is mostly Hepatitis B virus infection related. The antitumor efficacy of HBsAg gene-modified dendritic cells (DC) has been widely tested both in vitro and in vivo. In this study, we analyzed whether a...
CTLA-4 -1722T/C polymorphism and systemic lupus erythematosus susceptibility: a meta-analysis involving ten separate studies [0.03%]
CTLA-4 -1722T/C多态性与系统性红斑狼疮易感性的关系：包含10项独立研究的meta分析
Ji-Min Zhu,Bai-Kun Li,Gui-Mei Chen et al.
Ji-Min Zhu et al.
Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) -1722T/C polymorphism has been identified as a susceptibile gene for systemic lupus erythematosus (SLE), but studies are inconsistent. To better assess the association between CTLA-4 -172...
Age-associated changes in microRNA expression in bone marrow derived dendritic cells [0.03%]
骨髓来源树突状细胞中与年龄相关的microRNA表达变化
Seungbum Park,Soowon Kang,Kyung Hoon Min et al.
Seungbum Park et al.
MiRNAs have shown to regulate aging process at the level of cellular senescence, tissue aging, and lifespan of whole organism. Given that many miRNAs also function as important regulators of hematopoietic system as well as aging process, it...
Crucial role of CD4+CD 25+ FOXP3+ T regulatory cell, interferon-γ and interleukin-16 in malignant and tuberculous pleural effusions [0.03%]
CD4+CD25+FOXP3+调节性T细胞、干扰素-γ和白细胞介素-16在恶性及结核性胸腔积液中的作用
Lamiaa Ibrahim,Manal Salah,Azema Abd El Rahman et al.
Lamiaa Ibrahim et al.
The differential diagnosis between malignant and tuberculous exudative pleural effusions is an important clinical problem. The aim of current study is to evaluate the frequencies of T-regulatory cells (Treg) on the basis of distinct phenoty...
Intracellular CTLA4 and regulatory T cells in patients with laryngeal squamous cell carcinoma [0.03%]
喉部鳞状细胞癌患者的CTLAlG及其调节性T细胞
Nasrollah Erfani,Behzad Khademi,Mohammad Reza Haghshenas et al.
Nasrollah Erfani et al.
To explore if the increased percentages of Regulatory T (Treg) cells, as well as, overexpression of Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) are involved in laryngeal-squamous cell carcinoma (SCC), 45 patients with laryngeal-SCC and 27 hea...
Lan Li,Xuanling Shi,Qingyu Lu et al.
Lan Li et al.
Broadly neutralizing antibodies and appropriate immunogens are critical for preexposure prophylaxis and therapeutic HIV vaccines. In this study, we aimed to explore effective antibodies against the genetically diverse HIV-1 strains by inves...
Protection against cyclophosphamide-induced myelosuppression by ZPDC glycoprotein (24 kDa) [0.03%]
ZPDC糖蛋白(24kD)对环磷酰胺所致骨髓抑制的防护作用
Jin Lee,Kye-Taek Lim
Jin Lee
Immunomodulatory agents are often used to reduce myelosuppression and enhance immune response for cancer treatment. Cyclophosphamide (CTX) can induce oxidative stress in bone marrow resulting in suppression of anti-oxdiantive enzymes and ca...
Evaluation of high-mobility group box 1 protein concentration in serum of patients with M. tuberculosis infection [0.03%]
结核分枝杆菌感染患者血清高迁移率族蛋白箱1浓度测定及临床意义分析
Agnieszka Magryś,Jolanta Paluch-Oleś,Maria Kozioł-Montewka et al.
Agnieszka Magryś et al.
Infection with Mycobacterium tuberculosis is accompanied by an intense inflammatory response. Recently, a new mediator of inflammation, HMGB1 protein has been identified that contributes to acute lung injury. However, its role in the system...