Differential Control of T-Cell Subsets by Recombinant Human PLD2 in a Mouse Model of Allergic Asthma [0.03%]
重组人PLD2在小鼠过敏性哮喘模型中对T细胞亚群的差异调控作用
Hui-Li Wang,Chuan-Xing Yu,Xiu-Ming Yu et al.
Hui-Li Wang et al.
Background: Phospholipase D2 (PLD2) enzymes are expressed on the cytoplasmic membrane of bacteria, fungi, plants, and animals. Recently, extensive research has linked PLD2 to the chronic inflammatory activity of cells. Al...
Hanlu Zhang,Siyuan Luan,Fuqiang Wang et al.
Hanlu Zhang et al.
Background: Immune homeostasis plays a crucial role in immunology andis dependent on both central and peripheral tolerance. Centraltolerance and peripheral tolerance occur in the thymus and thesecondary lymphoid tissues, ...
Immunological Mechanisms of Sensorineural Hearing Impairment in Patients with Different Clinical Phenotypes of Chronic Rhinosinusitis: A Narrative Review [0.03%]
慢性鼻窦炎不同临床表型患者感音神经性听力损伤的免疫机制：综述文章
Aleksandar Peric,Dragoslava Djeric
Aleksandar Peric
Background: In this review article, we aimed to discuss the pathogenesis of sensorineural hearing loss (SNHL) in patients with different forms of chronic rhinosinusitis (CRS), with special reference to the connection of t...
miR-142-3p Regulates Airway Inflammation Through PTEN/AKT in Children and Mice with Asthma [0.03%]
miR-142-3p通过PTEN/AKT调节儿童和小鼠哮喘的气道炎症
Huiman Huang,Bo Sun,Bo Li et al.
Huiman Huang et al.
Background: Asthma is the most common chronic pulmonary disease in children. MicroRNAs (miRNAs) play a regulatory role in the occurrence and development of asthma. We aimed to explore the differential expression of miRNAs...
BMSCs Downregulate CXCL12 by Secreting Exosomal miR-20a-5p to Promote Macrophage M2 Polarization and Alleviate the Development of Sepsis [0.03%]
骨髓间充质干细胞通过分泌含miR-20a-5p的外泌体下调CXCL12，促进M2型巨噬细胞极化并缓解脓毒症发展
Liming Cheng,Bo Feng,Chao Xie et al.
Liming Cheng et al.
Objective: Sepsis is a syndrome of the systemic inflammatory response caused by infection that can endanger a patient's life. The aim of this study was to explore the molecular mechanism by which bone marrow mesenchymal s...
Serum-Derived Exosomal TBX2-AS1 Exacerbates COPD by Altering the M1/M2 Ratio of Macrophages through Regulating the miR-423-5p/miR-23b-3p Axis [0.03%]
血清衍生的外泌体TBX2-AS1通过调节miR-423-5P / miR-23B-3P轴改变巨噬细胞M1 / M2比例来加重COPD
JinHai Wang,Qing Luo,TiJun Gu et al.
JinHai Wang et al.
Objective: To investigate the mechanism of serum exosomes in chronic obstructive pulmonary disease (COPD), especially the effect of lncRNA TBX2-AS1 on macrophage polarization. ...
Differential Expression of Granulysin, MHC Class I-Related Chain A, and Perforin in Serum and Peritoneal Fluid: Immune Dysregulation in Endometriosis-Related Infertility [0.03%]
血清和腹腔液中粒细胞弹性蛋白酶、MHC-I相关链A和穿孔素的差异表达：子宫内膜异位症相关性不孕免疫调节异常
Fadhil Ahsan,Budi Santoso,Nanda Yuli Rahmawati et al.
Fadhil Ahsan et al.
Introduction: Endometriosis is a chronic inflammatory disease characterized by endometrial-like tissue outside the uterus. Molecules linked to natural killer (NK) and cytotoxic T cells, including granulysin (GNLY), MHC cl...
Evaluation of the Immunoadjuvant Effects of miR-155-Chitosan Polyplex on Leishmania major Infected Mice [0.03%]
评估miR-155-壳聚糖联聚物对利什曼原虫感染小鼠免疫佐剂效应的影响
Azam Pourabbasi Ardekan,Ali Haghighi,Samira Mohammadi-Yeganeh et al.
Azam Pourabbasi Ardekan et al.
Background: MicroRNAs have gained attention as key immunomodulators, with miR-155 specifically shown in various studies to drive macrophage polarization toward the classical phenotype. This polarization is crucial, as cla...
Combination Effect of Radiotherapy and Targeted Therapy with NK Cell-Based Immunotherapy in head and Neck Squamous Cell Carcinoma [0.03%]
放疗联合靶向治疗及基于自然杀伤细胞的免疫治疗在头颈鳞癌中的协同作用研究
Woo-Chang Son,Hong-Rae Lee,Eun-Kyoung Koh et al.
Woo-Chang Son et al.
Background: Head and neck squamous cell carcinoma (HNSCC) has a poor prognosis, and current treatments are limited by high toxicity and low survival rates, highlighting the need for new therapeutic approaches. Natural kil...
NOD1 Agonist Induces Proliferation and Plasma Cell Differentiation of Mouse B Cells Especially CD23high B Cells [0.03%]
NOD1激动剂诱导小鼠B细胞特别是CD23highB细胞的增殖和浆细胞分化
Cendrine Seguin,Michelle Seif,Célia Jacoberger-Foissac et al.
Cendrine Seguin et al.
Background: Like innate cells, B cells also express Pattern Recognition Receptors (PRRs) to detect danger signal such as tissue damage or pathogen intrusion. Production of specific antibodies by plasma cells results from ...