Synthesis and characterization of novel quinazoline type inhibitors for mutant and wild-type EGFR and RICK kinases [0.03%]
新型喹唑啉类抑制剂的合成与表征用于突变和野生型EGFR和RICK激酶
Nora Breza,Janos Pato,Laszlo Orfi et al.
Nora Breza et al.
The development of selective protein kinase inhibitors has become an important area of drug discovery for the treatment of different diseases. We report the synthesis and characterization of a series of novel quinazoline derivatives against...
Leptin receptors and beta2-adrenergic receptor mRNA expression in brain injury-related heterotopic ossification [0.03%]
脑损伤相关异位骨化的瘦素受体和β2-肾上腺素能受体mRNA表达
Christophe Chauveau,Jean-Christophe Devedjian,Christophe Delecourt et al.
Christophe Chauveau et al.
Heterotopic ossification (HO) frequently occurs after brain injury. Recently, we found that leptin levels were decreased in the serum of patients with HO. Data suggest two mechanisms mediating leptin effects: a central suppressive mechanism...
Integrated approach to immunotoxicity: electron transfer, reactive oxygen species, antioxidants, cell signaling, and receptors [0.03%]
免疫毒理学的综合研究方法：电子转移、活性氧、抗氧化剂、细胞信号转导和受体
Peter Kovacic,Ratnasamy Somanathan
Peter Kovacic
As with all body organs, the immune system is subjected to attack by a variety of toxins. Serious consequences can result because the immune organs serve as a defense against infective agents. The toxins, both organic and inorganic, fall in...
Interaction of sex hormone receptors and calcium handling proteins in the left ventricle of patients with heart failure [0.03%]
心力衰竭患者左心室性激素受体和钙处理蛋白的相互作用
Heart failure (HF) is one of the leading causes of death from cardiovascular disease among adults worldwide. The role of sex hormone receptors in the pathogenesis of HF and their regulatory mechanisms remain unclear. This study focused on i...
A novel anticancer candidate, coumarin-3-carboxamide derivative inhibits cell proliferation and migration in MDA-MB-231 cell line [0.03%]
新颖的抗肿瘤化合物香豆素-3-羧酰胺抑制MDA-MB-231细胞增殖和迁移作用研究
Breast cancer is one of the leading cancer types in terms of morbidity and mortality worldwide. Although developing technology, early diagnosis and treatment opportunities provide positive contributions to the treatment of breast cancer, re...