Identification of novel lead molecules against the EGFR kinase domain using structure-based virtual screening, molecular docking, and molecular dynamics simulations [0.03%]
基于结构的虚拟筛选、分子对接和分子动力学模拟结合发现EGFR激酶区新型先导化合物
Mythreyi Jannu,Umakanth Naik Vankadoth,Umamaheswari Amineni et al.
Mythreyi Jannu et al.
Epidermal growth factor receptor (EGFR) is a transmembrane protein belonging to the receptor tyrosine kinase (RTK) superfamily, reported as a promising anticancer target in treating diverse malignancies. Previous studies on microarray gene ...
ZC3H13-induced KLRB1 upregulation relieves the injury of myocardial infarction through N [6]-methyladenosine methylation [0.03%]
ZC3H13通过N[6]-甲基腺苷修饰诱导KLRB1上调以缓解心肌梗死损伤
Juan Zhou,Shun Zhang
Juan Zhou
Myocardial infarction (MI) is caused by blocked blood flow that leads to tissue damage and impaired cardiac function. This study explored the function and mechanism of Killer Cell Lectin-Like Receptor B1 (KLRB1) in MI, and examined how n6-m...
Targeting ubiquitin-specific peptidase 22 (USP22) as a nexus for drug repurposing in anticancer therapeutic development [0.03%]
靶向泛素特异性肽酶22（USP22）作为抗癌药物再定位的交汇点
Saad Ali Alshehri,Abdulrhman Alsayari,Mohammad Abohassan et al.
Saad Ali Alshehri et al.
Ubiquitin-specific peptidase 22 (USP22) has emerged as a promising target in cancer research because of its pivotal role in tumor progression, metastasis, and therapy resistance. USP22 is frequently overexpressed in multiple malignancies an...
Orphan G-protein coupled receptor 75 (GPR75), a unique and controversial potential therapeutic target [0.03%]
孤儿G蛋白偶联受体GPR75，一个独特且颇具争议的潜在药物作用靶点
Teodora Stratulat,Alexandru Babes,Sorin Tunaru
Teodora Stratulat
G protein-coupled receptors (GPCRs) are a large and diverse superfamily of membrane proteins that mediate cellular responses to a wide range of stimuli, making them critical players in a variety of physiological and pathological processes. ...
N-methyl-d-aspartate receptor is involved in the progression of anxiety disorders with thyroid tumors [0.03%]
N-甲基-D-天冬氨酸受体参与甲状腺肿瘤焦虑障碍进展中的作用
Meilan Su,Yuan Chang,Xiaoting Wu et al.
Meilan Su et al.
Background: Anxiety disorders (ADs) and thyroid tumors (TTs) are prevalent and frequently co-occur. Previous studies suggest that the N-methyl-d-aspartate receptor (NMDAR) may play a role in their co-occurrence, but the u...
Paradoxical action of zolpidem: interplay between dysregulation of the synergetic actions of γ-aminobutyric acid type A receptors and neuronal cotransporters (KCC2/NKCC1) [0.03%]
唑吡坦的悖论作用：γ-氨基丁酸A受体及神经共转运蛋白（KCC2/NKCC1）协同作用失调之间的相互作用
Ahmad Tarmizi Che Has,Fatin H Mohamad,Muhammad Zulfadhli Othman et al.
Ahmad Tarmizi Che Has et al.
Zolpidem, or commercially known as Ambien or Stilnox, is a sedative-hypnotic agent, which is usually prescribed to manage sleeping difficulties in individuals with insomnia. The site of its sedative-hypnotic action is the γ-aminobutyric ac...
Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario [0.03%]
子痫前期血浆可破坏内皮功能并促进内皮细胞炎症：格列本脲和MCC950的有益作用
Karoliny Nune Santos,Juliana Q Bizzotto,Thainá O Bueno-Pereira et al.
Karoliny Nune Santos et al.
Preeclampsia (PE) is characterized by systemic endothelial dysfunction and remains a significant clinical challenge. Activation of NLRP3 inflammasome, reactive oxygen species (ROS) production, and pyroptosis and autophagy are important mech...
The role of G protein-coupled receptor 4 in inflammatory diseases and its potential clinical significance [0.03%]
G蛋白偶联受体4在炎症性疾病中的作用及其潜在临床意义
Qilimuge Bai,Gegentuya Bao,Yali Yan et al.
Qilimuge Bai et al.
G protein-coupled receptor 4 (GPR4) is a dual ligand receptor that can be activated by both protons and lysophosphatidylcholine (LPC), which is a bioactive phospholipid. It plays a pivotal role in numerous physiological and pathological pro...
Regulation of elevated expression of Mcl-1 in hepatocellular carcinoma - a review [0.03%]
肝细胞癌中Mcl-1高表达的调控-综述文章
Li Chen,Yuwei He,Xudong Jiang et al.
Li Chen et al.
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors worldwide. Mcl-1 (myeloid cell leukemia-1) is highly expressed in HCC cells and plays a critical role in chemotherapy resistance and is a major contributor to chem...
Design and molecular mechanism investigation of ALK inhibitors based on virtual screening and structural descriptor modeling [0.03%]
基于虚拟筛选和结构描述符建模的ALK抑制剂的设计与分子机制研究
Ya-Kun Zhang,Jian-Bo Tong,Yue Sun et al.
Ya-Kun Zhang et al.
To address the challenges of target specificity and drug resistance in Anaplastic lymphoma kinase (ALK) inhibition, this study conducted a virtual screening of the BindingDB database, yielding 711 potential ALK inhibitors. Four QSAR models ...