In silico investigation of novel isatin derivatives as potential multi-target anticancer agents targeting VEGFR-2, EGFR, and caspase-6 [0.03%]
新型异烟酸衍生物作为潜在的多靶点抗肿瘤药物的研究——针对VEGFR-2、EGFR和半胱天冬酶-6靶点的理论研究
Vipul Kumar,Vivek Kumar,Prabodh Chander Sharma et al.
Vipul Kumar et al.
The isatin scaffold has emerged as a promising platform for the development of anticancer agents, as evidenced by several clinically relevant isatin-based compounds. In this study, 85 novel isatin derivatives were designed based on literatu...
Identification of receptor-interacting protein kinase 3 inhibitor for atherosclerosis [0.03%]
动脉粥样硬化相关受体相互作用蛋白激酶3抑制剂的识别
Angneh Ngoruh,Ananya Anurag Anand,Rik Ganguly et al.
Angneh Ngoruh et al.
Cardiovascular diseases are the major cause of death worldwide. Atherosclerosis is a chronic inflammatory condition characterized by the accumulation of atherosclerotic plaques in the artery walls of medium and large arteries. Receptor-inte...
Effects of diffusion, affinity, and permeation rate on drug cell therapy [0.03%]
扩散性、亲和性和渗透率对药物细胞治疗的影响
Terry Kenakin
Terry Kenakin
A mathematical model is described that enables calculation of drug concentration gradients within structured tissues for high affinity molecules that are taken up by cells. Access of drugs to the complete tissue mass may be prevented by hig...
Pharmacophore-based identification and molecular docking of CCR5 inhibitors: insights from dynamic simulations [0.03%]
基于药效团的CCR5抑制剂识别及分子对接：来自动力学模拟的新见解
Angadi Sathish Kumar,Estari Mamidala
Angadi Sathish Kumar
The chemokine receptor type 5 (CCR5) plays a crucial role in HIV-1 entry into host cells, making it a key therapeutic target. This study aimed to identify novel CCR5 inhibitors through pharmacophore-guided virtual screening and molecular dy...
Computational design, synthesis, and in vitro evaluation of thiadiazole-derived PARP-1 inhibitors [0.03%]
基于噻二唑的PARP-1抑制剂的计算设计、合成及体外评价
Hardha Balachandran,Sowmiya Arun,Kaviarasan Lakshmanan et al.
Hardha Balachandran et al.
Background: Poly (ADP-ribose) polymerase-1 (PARP-1) is a crucial enzyme in DNA repair pathways and a significant target for cancer therapy. Due to their favorable physicochemical and biological characteristics, heterocycl...
In silico investigation of Panchagavya Ghrita's anticancer potential against glioblastoma: a network pharmacology and molecular docking study [0.03%]
基于网络药理学和分子对接的Panchagavya Ghrita抗胶质母细胞瘤潜力的计算机研究
Omkar Giri,Ankita Ingole,Nilima Dharkar et al.
Omkar Giri et al.
Background: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, characterized by rapid progression, marked heterogeneity, and resistance to standard therapies. The complexity of its oncogenic network...
Molecular insights into voltage-gated sodium channels in excitable cells: pathophysiological roles and emerging therapeutic targets [0.03%]
兴奋性细胞中的电压门控钠通道的分子见解：病理生理作用和新兴治疗靶点
Akash Vikal,Rashmi Maurya,Pradeep Kumar et al.
Akash Vikal et al.
Voltage-gated sodium channels (VGSCs; Nav1.1-Nav1.9) are necessary for the initiation and propagation of action potentials in neurons, cardiac muscle and skeletal muscle. Because of their functional importance, VGSCs have become promising c...
β1/β2 adrenergic dysregulation: a missing link between mitochondrial fission/fusion in the failing heart [0.03%]
β1/β2肾上腺素能失衡：心力衰竭中线粒体分裂/融合的缺失环节
Pranav Panchbhai,Gauri Chaturvedi,Satnam Singh et al.
Pranav Panchbhai et al.
Heart failure (HF) is characterized by notable alterations in β-adrenergic receptor (β-AR) signaling. It is well known that a prolonged overstimulation of β-ARs, a member of the G-protein-coupled receptor (GPCR) family, alters receptor d...
Targeting vascular endothelial growth factor and its receptors in non-small cell lung cancer for improved treatment strategies [0.03%]
靶向血管内皮生长因子及其受体以改善非小细胞肺癌的治疗策略
Rajesh B Nanaware,Anuruddha R Chabukswar,Priyanka S Waghmare et al.
Rajesh B Nanaware et al.
Non-small cell lung cancer (NSCLC) is responsible for about 85% of all lung cancers and is a major contributor to cancer deaths worldwide. Angiogenesis, mainly mediated by vascular endothelial growth factor (VEGF) and its receptors (VEGFRs)...
Discrepancies in β-adrenergic receptor signaling and cAMP pathway in high-fat simple carbohydrate diet-fed C57BL/6J mice: implications for metabolic syndrome pathophysiology [0.03%]
高脂简单碳水化合物饮食喂养的C57BL/6J小鼠β肾上腺素能受体信号和cAMP通路差异：对代谢综合征病理生理学意义的影响
Vijayalakshmi Gangadhara,Kavishankar Gawli,Asha Abraham
Vijayalakshmi Gangadhara
The regulation of beta-adrenergic receptors (β-ARs) is crucial for maintaining pancreatic function and metabolic balance. However, the rising incidence of metabolic syndrome (MetS) highlights the need to understand how a high-fat simple ca...