Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic diabetes insipidus [0.03%]
血管加压素V2受体(R68W和V162A)突变体与Gαs及Gαq/11蛋白选择性耦联的差异性研究
Beril Erdem Tuncdemir
Beril Erdem Tuncdemir
Loss-of-function mutations of the arginine vasopressin receptor 2 gene (AVPR2) cause Nephrogenic diabetes insipidus (NDI). AVPR2 is a kind of G protein coupled receptor (GPCR) and mainly couples with Gαs protein leading to cAMP accumulatio...
Can calcitonin gene-related peptide (CGRP) and pentraxin-3 (PTX-3) be useful in diagnosing acute migraine attack? [0.03%]
降钙素基因相关肽和pentaxin-3在急性偏头痛诊断中的应用价值几何？
Sevilay Vural,Levent Albayrak
Sevilay Vural
Purpose: Even if migraine is not fatal, it is a common and challenging disease with adverse effects on individuals' lives. The lack of objective diagnostic tools causes delays in diagnosis and treatment initiation. The pr...
Target-based in-silico screening of basil polysaccharides against different epigenetic targets responsible for breast cancer [0.03%]
靶向基于计算的罗勒多糖筛选针对不同表观遗传学目标的乳腺癌治疗方法
Nancy Bhura,Pawan Gupta,Jeena Gupta
Nancy Bhura
Purpose: Breast cancer (BC) is one of the leading types of cancer found in women. One of the causes reported for BC is improper regulation of epigenetic modifications. Various epigenetic targets such as histone deacetylas...
Methylglyoxal enhances the proliferation of vascular smooth muscle cells via Akt phosphorylation [0.03%]
甲基乙二醛通过Akt磷酸化促进血管平滑肌细胞增殖
Mustafa Kırça
Mustafa Kırça
Methylglyoxal (MGO) is predominantly produced as a by-product of the glycolysis pathway. The glyoxalase system effectively removes it in a healthy organism. However, this process is impaired, and MGO level is elevated in people with diabete...
In silico screening of c-Met tyrosine kinase inhibitors targeting nucleotide and drug-substrate binding sites of ABCB1 as potential MDR reversal agents [0.03%]
针对ABCB1核苷酸和药物底物结合位点的c-Met酪氨酸激酶抑制剂的计算机筛选，作为潜在的多药耐药逆转剂
Fatemeh Moosavi,Tahereh Damghani,Somayeh Ghazi et al.
Fatemeh Moosavi et al.
Purpose: Cancer is a significant public health problem and ranks as a leading cause of death globally. Multidrug resistance (MDR) affects the therapeutic potential of conventional chemotherapeutic agents in cancer chemoth...
Ozone protects cardiomyocytes from myocardial ischemia-reperfusion injury through miR-200c/FOXO3 axis [0.03%]
臭氧通过miR-200c/FOXO3信号轴保护心肌细胞免受缺血再灌注损伤的影响
Lian Zhang,Xingping Men,Shenglong Yu et al.
Lian Zhang et al.
Purpose: Myocardial ischemia-reperfusion injury (I/R) is a detrimental process contributing to the pathological progression of coronary artery diseases. Studies indicate that miRNAs are implicated in ischemic heart diseas...
Anti-COVID-19 and antidiabetic activities of new oleanane and ursane-type triterpenoids from Salvia grossheimii: an in-silico approach [0.03%]
索拉维亚毛瓣亚种的新齐墩果烷和乌苏烷型三萜对新冠肺炎和糖尿病活性的体内研究
Somayeh Zare,Somayeh Pirhadi,Hesham R El Seedi et al.
Somayeh Zare et al.
Salvia grossheimii is a perennial herb with antidiabetic and cytotoxic constituents. In continuation of our study on S. grosshiemii to identify the bioactive phytochemicals, we have reported the characterization of seven undescribed triterp...
Selective thyroid hormone receptor beta agonist, GC-1, is capable to reduce growth of colorectal tumor in syngeneic mouse models [0.03%]
选择性甲状腺激素受体β激动剂GC-1能够减少同基因型小鼠结直肠肿瘤的生长
Katayoun Pourvali,Ghazaleh Shimi,Arman Ghorbani et al.
Katayoun Pourvali et al.
Objective: The effect of thyroid hormone (TH) on cancers was proposed more than 100 years ago; however, conclusions are conflicting. THs are precisely regulated at tissue and cellular levels. It seems that this regulation...
A review of protein-protein interaction and signaling pathway of Vimentin in cell regulation, morphology and cell differentiation in normal cells [0.03%]
细胞中间丝蛋白波形蛋白的蛋白质相互作用及其在正常细胞生长、形态和分化中的信号途径功能综述
Danial Hashemi Karoii,Hossein Azizi
Danial Hashemi Karoii
The Vimentin intermediate filament (VIF) is an essential cytoskeleton component. It shows dynamically changing expression patterns throughout various phases of the differentiation process, suggesting that the protein is physiologically impo...