Endothelial progenitor cells promote neural stem cell proliferation in hypoxic conditions through VEGF via the PI3K/AKT pathway [0.03%]
缺氧条件下内皮祖细胞通过VEGF介导的PI3K/AKT信号促进神经干细胞增殖
Jingti Jing,Haoming Jiang,Lin Zhang
Jingti Jing
Neurons and vascular cells compose neurovascular niches in the central nervous system where endothelial cells can promote neurogenesis via direct and indirect effects. Neurocytes and vascular cells are gravely destroyed upon spinal cord inj...
Determination of cytokine profile and associated genes of the signaling pathway in HNSCC [0.03%]
头颈癌细胞因子谱及其信号转导通路相关基因的确定
Aysel Kalayci Yigin,Ali Azzawri,Kayhan Ozturk et al.
Aysel Kalayci Yigin et al.
Head and neck squamose cell carcinoma (HNSCC) is an aggressive group of tumors that are generally heterogeneous. Despite treatment advances, disease-free survival has not significantly improved. Therefore, it is of great importance to under...
Correction [0.03%]
更正
Integrated computational approach for in silico design of new purinyl pyridine derivatives as B-Raf kinase inhibitors [0.03%]
新的嘌呤基吡啶衍生物的虚拟设计的一种综合计算方法这些新物质可以作为B-Raf激酶抑制剂
Vinutha Kuchana,Vaeshnavi Kashetti,Sai Kiran Reddy Peddi et al.
Vinutha Kuchana et al.
B-Raf is one among the most frequently mutating proto-oncogene which is associated with the serine/threonine Raf kinase family involved in the RAS-RAF-MEK-ERK pathway, which is the most deregulated pathway in human cancers. Mutant B-Raf V60...
Molecular docking study of britannin binding to PD-L1 and related anticancer pseudoguaianolide sesquiterpene lactones [0.03%]
Britannin与PD-L1结合及其相关的抗肿瘤伪瓜叶莲内酯倍半萜内酯的分子对接研究
Gérard Vergoten,Christian Bailly
Gérard Vergoten
The pseudoguaianolide-type sesquiterpene lactone (SL) britannin (BRT), found in different Inula species, has been characterized as a potent anticancer agent acting via modulation of the transcription factor NFkB and the Nrf2-Keap1 signaling...
DFT based QSAR study on quinolone-triazole derivatives as antibacterial agents [0.03%]
基于DFT的喹诺酮-三唑衍生物作为抗菌剂的QSAR研究
Niloofar Ghasedi,Shahin Ahmadi,Sepideh Ketabi et al.
Niloofar Ghasedi et al.
QSAR modeling was performed on 39 quinolone-triazole derivatives against gram-positive Staphylococcus aureus and gram-negative Pseudomonas aeruginosa bacteria. The molecular structures were optimized using the DFT/B3LYP method and 6-31 G ba...
PPARγ activation by pioglitazone enhances the anti-proliferative effects of doxorubicin on pro-monocytic THP-1 leukemia cells via inducing apoptosis and G2/M cell cycle arrest [0.03%]
吡格列酮通过诱导凋亡和G2/M细胞周期阻滞增强阿霉素对原单核THP-1白血病细胞的抗增殖作用的PPARγ激活效应
Hassan Ghasemi,Ali Jamshidi,Mohammad Amin Ghatee et al.
Hassan Ghasemi et al.
Purpose: Doxorubicin (DOX) is a common chemotherapeutic agent, with toxic side effects, and chemoresistance. Combination chemotherapy is a successful approach to overcome these limitations. Here, we investigated the effec...
Zingerone suppresses proliferation, invasion, and migration of hepatocellular carcinoma cells by the inhibition of MTDH-mediated PI3K/Akt pathway [0.03%]
姜根醇通过抑制MTDH介导的PI3K/Akt信号通路来抑制肝癌细胞的增殖，侵袭和转移
Jian Fang,Huifen Zhu,Pengcheng Xu et al.
Jian Fang et al.
Purpose: Previous studies have proved that zingerone was a therapeutic agent for many tumors. Metadherin (MTDH) acts as an oncogene and is involved in tumorigenesis. The purpose of this study was to explore the underlying...
Protective role of selenium on MPP+ and homocysteine-induced TRPM2 channel activation in SH-SY5Y cells [0.03%]
硒对MPP+和同型半胱氨酸诱导的SH-SY5Y细胞中TRPM2通道激活的保护作用
Kenan Yıldızhan,Mustafa Nazıroğlu
Kenan Yıldızhan
Homocysteine is an intermediate product of biochemical reactions occurring in living organisms. It is known that drugs that increase dopamine synthesis used in Parkinson's disease (PD) cause an increase in the plasma homocysteine level. As ...
In vivo and in vitro impact of miRNA-153 on the suppression of cell growth apoptosis through mTORC2 signaling pathway in breast cancer [0.03%]
microRNA-153通过mTORC2信号通路对乳腺癌细胞增殖和凋亡的体内及体外影响研究
Haimei Liu,Hongyan Zang,Jilin Kong et al.
Haimei Liu et al.
Purpose: To investigate the effects and mechanism of miRNA-153 on breast cancer cells in vitro and in vivo. Material and methods: The c...