Bone marrow mesenchymal stem cells inhibit ferroptosis via regulating the Nrf2-keap1/p53 pathway to ameliorate chronic kidney disease injury in the rats [0.03%]
骨髓间充质干细胞通过调节Nrf2-Keap1/p53信号通路抑制铁死亡从而改善慢性肾脏病损伤的研究
Lishi Shao,Qixiang Fang,Chen Shi et al.
Lishi Shao et al.
Purpose: Although bone marrow mesenchymal stem cells (BMMSCs) have been reported to exhibit a protective effect on animal models of chronic kidney disease (CKD), the exact mechanisms involved require further investigation...
2-{N-[(2,4,5-trichlorophenoxy) acetyl]-N-methylamino}-3-pyrrolidinepropanamide analogs as potential antagonists of Urotensin II receptor [0.03%]
2-{N-[(2,4,5-三氯苯氧基)乙酰基]-N-甲基氨基}-3-吡咯啉丙胺衍生物作为尿源素II受体的潜在拮抗剂
Ajay Soni,Subham Saha,Aditi Agarwal et al.
Ajay Soni et al.
The purpose of the article: To identify novel small molecule antagonists of Urotensin II receptor with acceptable pharmacological profile. Materials and m...
QSAR study of indole derivatives as active agents against Candida albicans: a DFT calculation [0.03%]
基于密度泛函理论的抗白色念珠菌(indole衍生物)活性先导化合物的QSAR研究
Hanie Aminaee,Sharieh Hosseini,Asghar Davood et al.
Hanie Aminaee et al.
Indole and its derivatives are common heterocyclic compounds in nature that have a wider range of medicinal activities such as antifungal, anti-inflammatory, and anti-seizure. Virtually all indole derivatives showed outstanding antifungal a...
Crosstalk between kisspeptin and gonadotropin-inhibitory hormone in the silence of puberty: preclinical evidence from a calcium signaling study [0.03%]
关于青春期静默期亲吻肽与促性腺激素抑制激素的相互作用：来自钙信号研究的前临床证据
Ferah Bulut,Emine Kacar,Batuhan Bilgin et al.
Ferah Bulut et al.
Kisspeptin and gonadotropin-inhibitory hormone (GnIH) are among suggested neuroendocrine modulators of reproductive function. Intracellular calcium signaling is a critical component in the regulation of a variety of physiological and pathol...
Identification of novel mycocompounds as inhibitors of PI3K/AKT/mTOR pathway against RCC [0.03%]
新型真菌化合物通过抑制PI3K/AKT/mTOR途径发挥抗RCC作用的鉴定研究
Ravi Prakash Yadav,Srilagna Chatterjee,Arindam Chatterjee et al.
Ravi Prakash Yadav et al.
PI3K/AKT/mTOR pathway is one of the frequently disrupted signaling pathways in renal cell carcinoma (RCC) that plays a significant role in tumor formation, disease progression and therapeutic resistance. Therefore, novel natural molecules t...
CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN [0.03%]
CBLC通过泛素化和降解CTTN抑制乳腺癌细胞的增殖和转移
Weiwei Li,Ting Lei,Xiaoyu Song et al.
Weiwei Li et al.
The E3 ubiquitin ligase is an important regulator of cell signaling and proteostasis and is tightly controlled in many diseases, including cancer. Our study aimed to investigate the biological role of the E3 ubiquitin ligase CBLC in breast ...
Pharmacological characterization of the α2A-adrenergic receptor inhibiting rat hippocampal CA3 epileptiform activity: comparison of ligand efficacy and potency [0.03%]
α2A-肾上腺素能受体药理学特征的抑制大鼠海马CA3癫痫样活动：配体效应与效力比较
Joseph P Biggane,Ke Xu,Brianna L Goldenstein et al.
Joseph P Biggane et al.
The mechanism underlying the antiepileptic actions of norepinephrine (NE) is unclear with conflicting results. Our objectives are to conclusively delineate the specific adrenergic receptor (AR) involved in attenuating hippocampal CA3 epilep...
Gαs and Gαq/11 protein coupling bias of two AVPR2 mutants (R68W and V162A) that cause nephrogenic diabetes insipidus [0.03%]
血管加压素V2受体(R68W和V162A)突变体与Gαs及Gαq/11蛋白选择性耦联的差异性研究
Beril Erdem Tuncdemir
Beril Erdem Tuncdemir
Loss-of-function mutations of the arginine vasopressin receptor 2 gene (AVPR2) cause Nephrogenic diabetes insipidus (NDI). AVPR2 is a kind of G protein coupled receptor (GPCR) and mainly couples with Gαs protein leading to cAMP accumulatio...
Can calcitonin gene-related peptide (CGRP) and pentraxin-3 (PTX-3) be useful in diagnosing acute migraine attack? [0.03%]
降钙素基因相关肽和pentaxin-3在急性偏头痛诊断中的应用价值几何？
Sevilay Vural,Levent Albayrak
Sevilay Vural
Purpose: Even if migraine is not fatal, it is a common and challenging disease with adverse effects on individuals' lives. The lack of objective diagnostic tools causes delays in diagnosis and treatment initiation. The pr...
Target-based in-silico screening of basil polysaccharides against different epigenetic targets responsible for breast cancer [0.03%]
靶向基于计算的罗勒多糖筛选针对不同表观遗传学目标的乳腺癌治疗方法
Nancy Bhura,Pawan Gupta,Jeena Gupta
Nancy Bhura
Purpose: Breast cancer (BC) is one of the leading types of cancer found in women. One of the causes reported for BC is improper regulation of epigenetic modifications. Various epigenetic targets such as histone deacetylas...