An in-silico approach - molecular docking analysis of flavonoids against GSK-3β and TNF-α targets in Alzheimer's disease [0.03%]
基于计算的分子对接分析法研究黄酮类化合物对阿尔茨海默病GSK-3β和TNF-α靶点的作用
Sittarthan Viswanathan,Rengaraj Sivaraj,A Hannah Rachel Vasanthi et al.
Sittarthan Viswanathan et al.
Introduction: Drug development for Alzheimer's disease has one of the greatest failure rates of any therapeutic field and AD is still incurable. Glycogen synthase kinase-3β is a critical enzyme implicated in the pathogen...
The vasodilator effect of Eugenol on uterine artery - potential therapeutic applications in pregnancy-associated hypertension [0.03%]
肉桂醇对子宫动脉的血管舒张作用及其在妊娠高血压治疗中的潜在应用价值
Harithalakshmi Jandhyam,Bimal Prasanna Mohanty,Subas Chandra Parija
Harithalakshmi Jandhyam
Preeclampsia, a gestational associated hypertension, has been reported in 6-8% of pregnant women worldwide leading to premature delivery and low birth weight of newborn due to reduced blood flow to placenta. Although several vasodilators (M...
Low pH modulates lipopolysaccharide-induced tumor necrosis factor-alpha expression and macropinocytotic activity in RAW264.7 cells [0.03%]
低pH调节脂多糖诱导的肿瘤坏死因子-α表达及巨噬细胞RAW264.7的巨胞饮活性
Miku Otsugu,Ayumi Mine,Izumi Uchida et al.
Miku Otsugu et al.
Inflammation triggers various types of diseases that need to be addressed. Macrophages play important roles in the inflammatory responses. As atherosclerosis progresses, macrophages transform into foam cells. Extracellular acidification is ...
The roles of angiotensin-converting enzyme 2 inhibitor, melatonin and its agonist on angiotensin II reactivity in intact and denuded rat aortic rings [0.03%]
血管紧张素转换酶2抑制剂、褪黑素及其受体激动剂对完整和去膜的鼠主动脉环中血管紧张素Ⅱ反应性的作用研究
Nazar M Shareef Mahmood,Almas Mr Mahmud,Ismail M Maulood
Nazar M Shareef Mahmood
Background: The pineal product melatonin (MEL) modulates blood vessels through G protein-coupled receptors (GPCRs) called melatonin type 1 receptor (MT1R) and melatonin type 2 receptor (MT2R), in that order. The renin-ang...
4-octyl itaconate inhibits high glucose induced renal tubular epithelial cell fibrosis through TGF-β-ROS pathway [0.03%]
丁香酸酯通过TGF-β-ROS途径抑制高糖诱导的肾小管上皮细胞纤维化
Xiaoli Zou,Maoyan Wu,Mengqin Tu et al.
Xiaoli Zou et al.
Diabetic kidney disease (DKD) is one of the most serious complications of diabetes and has become the leading cause of end-stage kidney disease, causing serious health damage and a huge economic burden. Tubulointerstitial fibrosis play impo...
Intracerebroventricular injection of kisspeptin in male rats activates hypothalamo-pituitary-gonadal axis, but not hypothalamo-pituitary-adrenal axis [0.03%]
利克肽脑室内注射激活雄性大鼠下丘脑-垂体-性轴，但不激活下丘脑-垂体-肾上腺轴
Zafer Sahin,Osman Aktas,Omer Faruk Kalkan et al.
Zafer Sahin et al.
Kisspeptin is an important hormone involved in the stimulation of the hypothalamo-pituitary gonadal (HPG) axis. The HPG axis can be suppressed in certain conditions such as stress, which gives rise to the activation of the hypothalamo-pitui...
Mechanistic insights into sodium ion-mediated ligand binding affinity and modulation of 5-HT2B GPCR activity: implications for drug discovery and development [0.03%]
钠离子介导配体与五羟色胺2B受体结合亲和力及对五羟色胺2B受体活性调节的机制见解：药物研发启示与发展
Arushi Chauhan,Jitender Singh,Namrata Sangwan et al.
Arushi Chauhan et al.
Purpose: The G-protein coupled receptor (GPCR) family, implicated in neurological disorders and drug targets, includes the sensitive serotonin receptor subtype, 5-HT2B. The influence of sodium ions on ligand binding at th...
cGAS-STING and PD1/PDL-1 pathway in breast cancer: a window to new therapies [0.03%]
乳腺癌中的cGAS-STING 和 PD1/PDL-1 通路：新疗法的窗口
Milad Khorasani,Maryam Alaei
Milad Khorasani
Breast cancer is a complex malignancy with diverse molecular and cellular subtypes and clinical outcomes. Despite advances in treatment, breast cancer remains a significant health challenge. However, recent advances in cancer immunotherapy ...
New synthetic derivatives of isoindoline-dione: synthesis, neuroprotection assay and impact on the expression level of oxidative stress-related genes in neuronal-like cell line [0.03%]
新的异吲哚啉二酮合成衍生物：合成、神经保护测定以及对类神经细胞系中氧化应激相关基因表达水平的影响
Abdolrahim Pourparizi,Mina Vazirinia,Fatemeh Pourrajab et al.
Abdolrahim Pourparizi et al.
Purpose: Oxidative stress can damage cells and cause age-related illnesses such as Alzheimer's, Parkinson's, and Huntington's. This study looked at newly synthesized isoindole derivatives and their effects on SH-SY5Y as a...
MicroRNA-124a regulates the differentiation of bone marrow mesenchymal stem cells into neurons [0.03%]
微RNA-124a调节骨髓间充质干细胞向神经元的分化
Eryi Zhao,Daimei Wang,Lijun Jing et al.
Eryi Zhao et al.
Objective: This study investigated the effects of microRNA-124a on the differentiation of bone marrow mesenchymal stem cells (BMSCs) and its underlying mechanism. ...