The roles of angiotensin-converting enzyme 2 inhibitor, melatonin and its agonist on angiotensin II reactivity in intact and denuded rat aortic rings [0.03%]
血管紧张素转换酶2抑制剂、褪黑素及其受体激动剂对完整和去膜的鼠主动脉环中血管紧张素Ⅱ反应性的作用研究
Nazar M Shareef Mahmood,Almas Mr Mahmud,Ismail M Maulood
Nazar M Shareef Mahmood
Background: The pineal product melatonin (MEL) modulates blood vessels through G protein-coupled receptors (GPCRs) called melatonin type 1 receptor (MT1R) and melatonin type 2 receptor (MT2R), in that order. The renin-ang...
4-octyl itaconate inhibits high glucose induced renal tubular epithelial cell fibrosis through TGF-β-ROS pathway [0.03%]
丁香酸酯通过TGF-β-ROS途径抑制高糖诱导的肾小管上皮细胞纤维化
Xiaoli Zou,Maoyan Wu,Mengqin Tu et al.
Xiaoli Zou et al.
Diabetic kidney disease (DKD) is one of the most serious complications of diabetes and has become the leading cause of end-stage kidney disease, causing serious health damage and a huge economic burden. Tubulointerstitial fibrosis play impo...
Intracerebroventricular injection of kisspeptin in male rats activates hypothalamo-pituitary-gonadal axis, but not hypothalamo-pituitary-adrenal axis [0.03%]
利克肽脑室内注射激活雄性大鼠下丘脑-垂体-性轴，但不激活下丘脑-垂体-肾上腺轴
Zafer Sahin,Osman Aktas,Omer Faruk Kalkan et al.
Zafer Sahin et al.
Kisspeptin is an important hormone involved in the stimulation of the hypothalamo-pituitary gonadal (HPG) axis. The HPG axis can be suppressed in certain conditions such as stress, which gives rise to the activation of the hypothalamo-pitui...
Mechanistic insights into sodium ion-mediated ligand binding affinity and modulation of 5-HT2B GPCR activity: implications for drug discovery and development [0.03%]
钠离子介导配体与五羟色胺2B受体结合亲和力及对五羟色胺2B受体活性调节的机制见解：药物研发启示与发展
Arushi Chauhan,Jitender Singh,Namrata Sangwan et al.
Arushi Chauhan et al.
Purpose: The G-protein coupled receptor (GPCR) family, implicated in neurological disorders and drug targets, includes the sensitive serotonin receptor subtype, 5-HT2B. The influence of sodium ions on ligand binding at th...
cGAS-STING and PD1/PDL-1 pathway in breast cancer: a window to new therapies [0.03%]
乳腺癌中的cGAS-STING 和 PD1/PDL-1 通路：新疗法的窗口
Milad Khorasani,Maryam Alaei
Milad Khorasani
Breast cancer is a complex malignancy with diverse molecular and cellular subtypes and clinical outcomes. Despite advances in treatment, breast cancer remains a significant health challenge. However, recent advances in cancer immunotherapy ...
New synthetic derivatives of isoindoline-dione: synthesis, neuroprotection assay and impact on the expression level of oxidative stress-related genes in neuronal-like cell line [0.03%]
新的异吲哚啉二酮合成衍生物：合成、神经保护测定以及对类神经细胞系中氧化应激相关基因表达水平的影响
Abdolrahim Pourparizi,Mina Vazirinia,Fatemeh Pourrajab et al.
Abdolrahim Pourparizi et al.
Purpose: Oxidative stress can damage cells and cause age-related illnesses such as Alzheimer's, Parkinson's, and Huntington's. This study looked at newly synthesized isoindole derivatives and their effects on SH-SY5Y as a...
MicroRNA-124a regulates the differentiation of bone marrow mesenchymal stem cells into neurons [0.03%]
微RNA-124a调节骨髓间充质干细胞向神经元的分化
Eryi Zhao,Daimei Wang,Lijun Jing et al.
Eryi Zhao et al.
Objective: This study investigated the effects of microRNA-124a on the differentiation of bone marrow mesenchymal stem cells (BMSCs) and its underlying mechanism. ...
Synthesis, in silico and in vitro anti-cancer studies of phosphorylated derivatives of didanosine targeting MDA-MB-231 breast cancer cell lines [0.03%]
齐多夫定磷酸衍生物的合成及其针对MDA-MB-231乳腺癌细胞系的体内外抗肿瘤研究
S K Thaslim Basha,S Mahaboob Basha,D Subba Rao et al.
S K Thaslim Basha et al.
A series of new phosphorylated derivatives of didanosine were designed, synthesized and evaluated their anticancer effects on human breast cancer cells. Their binding affinities were evaluated against aromatase enzyme and the molecular dock...
Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE) [0.03%]
神经毒剂与乙酰胆碱酯酶(AChE)结合及毒性研究
Mikael Ham Sembiring,Okta Nursanti,Tesia Aisyah Rahmania
Mikael Ham Sembiring
Acetylcholinesterase (AChE) is a cholinergic enzyme that plays an essential role in the autonomic nervous system. This enzyme is often the target of many nerve agents. When this enzyme is inhibited, its function to hydrolyze acetylcholine i...
Exploring the composition of protein-ligand binding sites for cancerous inhibitor of PP2A (CIP2A) by inhibitor guided binding analysis: paving a new way for the Discovery of drug candidates against triple negative breast cancer (TNBC) [0.03%]
通过抑制剂引导的结合分析探索癌症PP2A抑制剂(CIP2A)蛋白-配体结合位点的组成：为发现三阴性乳腺癌(TNBC)药物候选物铺平新道路
Oluwayimika Ibitoye,Mahmoud A A Ibrahim,Mahmoud E S Soliman
Oluwayimika Ibitoye
Triple-negative breast cancer (TNBC) is associated with high-grade invasive carcinoma leading to a 10% to 15% death rate in younger premenopausal women. Targeting cancerous inhibitors of protein phosphatase (CIP2A) has been a highly effecti...