The cannabinoid CB2 receptor positive allosteric modulator EC21a exhibits complicated pharmacology in vitro [0.03%]
cannabinoid CB2受体激动剂EC21a的复杂药理学性质体外研究
Aidong Qi,Xueqing Han,Marc Quitalig et al.
Aidong Qi et al.
Schizophrenia is a complex disease involving the dysregulation of numerous brain circuits and patients exhibit positive symptoms (hallucinations, delusions), negative symptoms (anhedonia), and cognitive impairments. We have shown that the a...
Acetylcholinesterase - glucose-regulated protein 78 binding site prediction, a hope to cure neurological disorders such as Alzheimer's disease [0.03%]
乙酰胆碱酯酶-葡萄糖调节蛋白78结合位点预测或可治愈阿尔茨海默病等神经性疾病
Ahmed M Ali,Ahmed A Mohamed,Ahmed N Ibrahim et al.
Ahmed M Ali et al.
Cerebral amyloid plaques in the brain define the elderly neuralgic disorder, Alzheimer's disease (AD). The enzyme Acetylcholinesterase (AChE) was reported to play a vital role in AD. It was shown that AChE induces amyloid fibril formation f...
Lycopene induces antiproliferative effects through apoptosis, autophagy, and oxidative DNA damage in the HeLa cells [0.03%]
番茄红素通过诱导HeLa细胞凋亡、自噬和氧化性DNA损伤而产生抗增殖作用
Mesut Parlak,Ziad Joha,Fatih Yulak et al.
Mesut Parlak et al.
Background: This study explores the role of apoptosis, autophagy, and oxidative DNA damage in influencing the cytotoxic impact of lycopene on HeLa cells. ...
UBE2C, targeted by miR-140-3p, promotes the progression of osteosarcoma via PI3K/AKT signaling pathway [0.03%]
UBE2C通过PI3K / AKT信号通路促进成骨肉瘤的进展，该通路由miR-140-3p靶向作用
Wenze Huang,Yan Zhou,Jing Ren et al.
Wenze Huang et al.
Background: UBE2C was reported to play carcinogenic effects in diverse cancers. However, the role of UBE2C in osteosarcoma was poorly understood, and its functional mechanisms were not fully clarified. ...
Allosteric covalent inhibition of TOE1 as potential unexplored anti-cancer target: structure-based virtual screening and covalent molecular dynamics analysis [0.03%]
基于结构的虚拟筛选及共价分子动力学分析协同催化抑制TOE1作为潜在的抗癌靶点的可能性研究
Ibrahim Oluwatobi Kehinde,Ernest Oduro-Kwateng,Mahmoud E S Soliman
Ibrahim Oluwatobi Kehinde
Cancer remains a formidable challenge in therapeutic development owing to its complex molecular mechanisms and resistance to conventional treatments. Recent evidence suggests that TOE1 may play a role in cancer progression, making it an att...
Virtual screening, molecular docking and dynamics simulation studies to identify potential agonists of orphan receptor GPR78 targeting CNS disorders [0.03%]
针对中枢神经系统疾病的孤儿受体GPR78虚拟筛选、分子对接及动态模拟研究以识别潜在激动剂
Vasavi Garisetti,Roslin Elsa Varughese,Arthikasree Anandamurthy et al.
Vasavi Garisetti et al.
G protein-coupled receptors (GPCRs) are important targets in drug discovery because of their roles in physiological and pathological processes. Orphan GPCRs are GPCR proteins for which endogenous ligands have not yet been identified and the...
Heat shock protein (Hsp27)-ceramide synthase (Cers1) protein-protein interactions provide a new avenue for unexplored anti-cancer mechanism and therapy [0.03%]
热休克蛋白(Hsp27)- ceramide synthase(Cers1)蛋白质-蛋白质相互作用为抗癌机制和疗法提供了新的途径
Musab Ali,Zhichao Zhang,Mahmoud A A Ibrahim et al.
Musab Ali et al.
Hsp27 is a member of the small heat-shock proteins (sHSPs) - the known cellular line of defence against abnormal protein folding behaviors. Nevertheless, its upregulation is linked to a variety of pathological disorders, including several t...
An in-silico approach - molecular docking analysis of flavonoids against GSK-3β and TNF-α targets in Alzheimer's disease [0.03%]
基于计算的分子对接分析法研究黄酮类化合物对阿尔茨海默病GSK-3β和TNF-α靶点的作用
Sittarthan Viswanathan,Rengaraj Sivaraj,A Hannah Rachel Vasanthi et al.
Sittarthan Viswanathan et al.
Introduction: Drug development for Alzheimer's disease has one of the greatest failure rates of any therapeutic field and AD is still incurable. Glycogen synthase kinase-3β is a critical enzyme implicated in the pathogen...
The vasodilator effect of Eugenol on uterine artery - potential therapeutic applications in pregnancy-associated hypertension [0.03%]
肉桂醇对子宫动脉的血管舒张作用及其在妊娠高血压治疗中的潜在应用价值
Harithalakshmi Jandhyam,Bimal Prasanna Mohanty,Subas Chandra Parija
Harithalakshmi Jandhyam
Preeclampsia, a gestational associated hypertension, has been reported in 6-8% of pregnant women worldwide leading to premature delivery and low birth weight of newborn due to reduced blood flow to placenta. Although several vasodilators (M...
Low pH modulates lipopolysaccharide-induced tumor necrosis factor-alpha expression and macropinocytotic activity in RAW264.7 cells [0.03%]
低pH调节脂多糖诱导的肿瘤坏死因子-α表达及巨噬细胞RAW264.7的巨胞饮活性
Miku Otsugu,Ayumi Mine,Izumi Uchida et al.
Miku Otsugu et al.
Inflammation triggers various types of diseases that need to be addressed. Macrophages play important roles in the inflammatory responses. As atherosclerosis progresses, macrophages transform into foam cells. Extracellular acidification is ...