Angiotensin III activates ERK1/2 mitogen activated protein kinases and proliferation of rat vascular smooth muscle cells [0.03%]
血管紧张素Ⅲ通过活化ERK1/2丝裂原激活的蛋白激酶促进大鼠血管平滑肌细胞增殖
Ahmed Z Alanazi,Michelle A Clark
Ahmed Z Alanazi
The proliferative effects of angiotensin (Ang) II in vascular smooth muscle cells (VSMCs) through its ability to stimulate extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway have been established. The main goal of this study wa...
Novel therapeutic approaches targeting 5-HT7 receptors outside the central nervous system [0.03%]
针对中枢神经系统外5-ht7受体的新型治疗策略
Melis Kilic,Zeynep Karakoy,Hamza Halici et al.
Melis Kilic et al.
Serotonin (5-HT) is a neurotransmitter found throughout the human body that regulates many physiological events arising from the brain and central nervous system (CNS), such as sleep and appetite. However, it has many other functions in sys...
Deciphering the involvement of norepinephrine and β-adrenergic receptor subtypes in glucose induced insulin secretion: an integrated in silico and in vitro exploration using isolated pancreatic islets of C57BL/6J mice [0.03%]
nor肾上腺素和β-肾上腺素能受体亚型在葡萄糖诱导的胰岛素分泌中的作用：使用C57BL/6J小鼠分离的胰岛进行的整合式计算机模拟与体外探索
Vijayalakshmi Gangadhara,Asha Abraham
Vijayalakshmi Gangadhara
Regulating insulin production by pancreatic beta cells is crucial for maintaining metabolic balance. Previous studies observed elevated neurotransmitter levels, like norepinephrine (NE), in metabolic syndrome mice with impaired insulin secr...
Computational insights into potent USP5 inhibitors based on multistep virtual screening and molecular dynamics simulation [0.03%]
基于多步虚拟筛选和分子动力学模拟的潜在USP5抑制剂的计算研究
Qian Xie,Linan Zhao,Dong Hu et al.
Qian Xie et al.
USP5 is widely distributed in various malignant tumors and can regulate the stability and promoting tumor progression of many tumor-related proteins. However, there is still a lack of highly active USP5 inhibitors. Therefore, effective inhi...
Abhijit Debnath,Rajesh Kumar Singh,Rupa Mazumder et al.
Abhijit Debnath et al.
CDK12 is essential for cellular processes like RNA processing, transcription, and cell cycle regulation, inhibiting cancer cell growth and facilitating macrophage invasion. CDK12 is a significant oncogenic factor in various cancers, includi...
Effect of dapagliflozin on pulmonary vascular remodeling in rats with chronic hypoxic pulmonary arterial hypertension [0.03%]
达格列净对慢性低氧大鼠肺动脉高压肺血管重塑的影响
Yi Xu,Wenxue Liang,Juan Huo et al.
Yi Xu et al.
Objective: To investigate the effects of sodium-glucose co-transporter 2 inhibitor dapagliflozin on pulmonary vascular remodeling in a rat model of chronic hypoxic pulmonary arterial hypertension. ...
Evaluation of the effect of Helicobacter pylori -derived OMVs and released exosomes from stomach cells treated with OMVs on the expression of genes related to the TGF-β/SMAD signaling pathway in hepatocellular carcinoma [0.03%]
评估幽门螺旋杆菌来源的外膜囊泡及其释放的细胞处理后的细胞外小体对肝癌细胞TGF-β / SMAD信号通路相关基因表达的影响
Zohreh Mohammadi Azad,Mehrdad Moosazadeh Moghaddam,Mahdi Fasihi-Ramandi et al.
Zohreh Mohammadi Azad et al.
OMVs derived from Helicobacter pylori can lead to cell transformation in gastric epithelium and cancer. Additionally, exosomes (Exos) released by host cells infected with H. pylori can significantly contribute to the development of diseases...
Effect of elastin on abnormal proliferation of pulmonary artery smooth muscle cells at an early stage of hypoxic exposure [0.03%]
缺氧早期弹性蛋白影响肺动脉平滑肌细胞异常增殖的作用研究
Hao Dong,Pengshuai Li,Xuefei Wang et al.
Hao Dong et al.
Elastin (Eln) is an extracellular matrix protein implicated in the proliferation of vascular smooth muscle cells. However, its potential role in hypoxic pulmonary hypertension (HPH) remains uncertain. This study is the first to demonstrate ...
The combined use of thymoquinone and metformin provides more effective neuroprotection in a mouse model of MPTP-induced Parkinson's disease [0.03%]
在MPTP诱导的帕金森病小鼠模型中，用异硫氰酸盐和二甲双胍联合使用能提供更有效的神经保护作用
Oguzhan Kavrik,Nurhan Gumral,Ozlem Ozmen et al.
Oguzhan Kavrik et al.
Thymoquinone (TQ) is known for its antioxidant properties, and although metformin (MM) is known as an antidiabetic drug, it is suggested that it reduces neurodegeneration. The study aimed to investigate the neuroprotective effects of TQ and...
Investigating the inhibitory potential of natural bioactive compounds against cyclin-dependent kinase 13: virtual high throughput screening and MD simulation studies to target CDK signaling [0.03%]
针对CDK信号通路靶点的虚拟高通量筛选及分子动力学模拟研究天然生物活性化合物对周期素依赖性激酶13的抑制潜力
Zehra,Farah Anjum,Talha Jawaid et al.
Zehra et al.
Cyclin-dependent kinase 13 (CDK13) belongs to the cyclin-dependent kinase (CDK) family that is actively involved in transcription regulation and RNA splicing. CDK13 binds with its partner, cyclin K, to regulate several biological processes....