Thrombomodulin promotes placental function by up-regulating placental growth factor via inhibition of high-mobility-group box 1 and hypoxia-inducible factor 1α [0.03%]
thrombomodulin通过抑制高迁移率族盒蛋白1和缺氧诱导因子1α上调胎盘生长因子促进胎盘功能
Hiroko Oda,Takeshi Nagamatsu,Horacio Cabral et al.
Hiroko Oda et al.
Introduction: Pregnancy is a state of maternal systemic stress due to inflammation and hypoxic reactions originating from the utero-placental unit. Maternal tolerance to these stresses is a key for successful outcomes. Th...
N-acetylcysteine, xCT and suppression of Maxi-chloride channel activity in human placenta [0.03%]
N-乙酰半胱氨酸、xCT和人类胎盘最大氯通道活性的抑制作用
Emma M Lofthouse,Antigoni Manousopoulou,Jane K Cleal et al.
Emma M Lofthouse et al.
Introduction: Placental oxidative stress features in pregnancy pathologies but in clinical trials antioxidant supplementation has not improved outcomes. N-acetylcysteine (NAC) stimulates glutathione production and is prop...
PLAC1 affects cell to cell communication by interacting with the desmosome complex [0.03%]
PLAC1通过与桥粒复合物相互作用来影响细胞间通讯
Yaohui Chen,Carole Stagg,David Schlessinger et al.
Yaohui Chen et al.
Introduction: X-linked PLAC1 is highly expressed in placenta during embryogenesis, and when ablated in mice, causes aberrant placental cell layer organization. It is also highly expressed in many types of cancer cell-line...
Chronic hypoxia in pregnant mice impairs the placental and fetal vascular response to acute hypercapnia in BOLD-MRI hemodynamic response imaging [0.03%]
慢性缺氧小鼠的胎盘和胎儿血管对急性高碳酸血症的反应受损（BOLD-MRI血流动力学反应成像）
Yehuda Ginosar,Zohar Bromberg,Nathalie Nachmanson et al.
Yehuda Ginosar et al.
Introduction: Brief hypercapnic challenge causes acute placental hypoperfusion with fetal brain sparing on BOLD-MRI. We hypothesize that this non-invasive imaging strategy can distinguish between normal pregnancy and chro...
Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study [0.03%]
新加坡-GUSTO队列研究中孕期26周母体循环SPINT1水平在小于胎龄妊娠中降低
Tu&#x;uhevaha J Kaitu&#x;u-Lino,Stephen Tong,Susan P Walker et al.
Tu&#x;uhevaha J Kaitu&#x;u-Lino et al.
Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low maternal circulating SPINT1 concentrations as a novel biomarker of poor fetal growth. Here we measured SPINT1 in a pr...
Identification and validation of DNA methylation changes in pre-eclampsia [0.03%]
子痫前期DNA甲基化变化的鉴定与验证
Suzan N Almomani,Abdulmonem A Alsaleh,Robert J Weeks et al.
Suzan N Almomani et al.
Introduction: Pre-eclampsia (PE) is a dangerous placental condition that can lead to premature labour, seizures and death of mother and infant. Several studies have identified altered placental DNA methylation in PE; howe...
Emma Siragher,Amanda N Sferruzzi-Perri
Emma Siragher
Intrauterine hypoxia is a feature of pregnancy complications, both at high altitude and sea level. To understand the placental response to reduced oxygen availability, small animal models of maternal inhalation hypoxia (MIH) or reduced uter...
Placental pathology in COVID-19 affected pregnant women: A prospective case-control study [0.03%]
受COVID-19影响的孕妇胎盘病理改变：一项前瞻性病例对照研究
Chiara Tasca,Roberta Simona Rossi,Silvia Corti et al.
Chiara Tasca et al.
Introduction: During pregnancy, SARS-CoV-2 infection may cause an abnormal development of the placenta, thus influencing maternal and fetal outcomes. Few studies have reported data on placental morphology and histology in...
Multicenter Study
Placenta. 2021 Jul:110:9-15. DOI:10.1016/j.placenta.2021.04.002 2021
Syncytiotrophoblast stress in early onset preeclampsia: The issues perpetuating the syndrome [0.03%]
早期子痫前期的合胞体滋养细胞压力及持续发病的机制问题
Ivo Carrasco-Wong,Macarena Aguilera-Olguín,Rodrigo Escalona-Rivano et al.
Ivo Carrasco-Wong et al.
Preeclampsia is a pregnancy-specific syndrome characterized by a sudden increase in blood pressure accompanied by proteinuria and/or maternal multi-system damage associated to poor fetal outcome. In early-onset preeclampsia, utero-placental...
Placental chemical elements concentration in small fetuses and its relationship with Doppler markers of placental function [0.03%]
小孕囊胎盘元素含量及其与胎盘功能多普勒标志物之间的关系
M D Gómez-Roig,E Mazarico,D Cuadras et al.
M D Gómez-Roig et al.
Introduction: In this study, we aimed at quantifying placental concentrations of 22 chemical elements in small fetuses (SGA) as compared with normally grown fetuses (AGA), and to assess the relationship with Doppler marke...