Smaller placentas and maternal vascular malperfusion are associated with worse pregnancy outcomes in triplet pregnancies with a monochorionic component [0.03%]
单绒毛膜成分的三胎妊娠中，较小的胎盘和母体血管灌注不良与较差的妊娠结局相关
Eva Manuela Pena-Burgos,Emma García-Munuera,Jose Juan Pozo-Kreilinger et al.
Eva Manuela Pena-Burgos et al.
Introduction: This study aimed to compare placental pathological findings and the prevalence of maternal, fetal, obstetric, and perinatal outcomes in triplet pregnancies based on chorionicity. ...
Anti-β2GPI antibodies induce trophoblast pyroptosis and placental inflammation through TLR4/NLRP3/GSDMD axis [0.03%]
抗β2GPI抗体通过TLR4/NLRP3/GSDMD轴诱导滋养细胞焦亡和胎盘炎症
Mingyang Xu,Xiaoyu Ji,Hongyuan Zhang et al.
Mingyang Xu et al.
Objective: Obstetric antiphospholipid syndrome (OAPS) is an autoimmune disease characterized by the persistent presence of anti-β2-glycoprotein I (anti-β2GPI) antibodies. Placental inflammation, particularly involving t...
Impact of placenta-derived extracellular vesicles on endothelial function in supraphysiological maternal hypercholesterolemia [0.03%]
胎盘源性外泌体对母体高胆固醇血症血管内皮功能的影响研究
Claudette Cantin,Jaime Gutiérrez,Reyna Peñailillo et al.
Claudette Cantin et al.
Maternal physiological hypercholesterolemia (MPH; total cholesterol (TC)≤280 mg/dL) occurs during pregnancy to support fetal growth. When TC exceeds this threshold, this condition is recognized as maternal supraphysiological hypercholester...
Unraveling the role of miRNAs in placental function: insights into trophoblast biology and pregnancy pathology [0.03%]
microRNA在胎盘功能中的作用及其对滋养层生物学和妊娠疾病的影响研究
Yanjie Guo,Cheuk-Lun Lee,Yajing Meng et al.
Yanjie Guo et al.
MicroRNAs (miRNAs) are pivotal regulators of placental development and function, orchestrating critical processes such as trophoblast proliferation, differentiation, invasion, and vascular remodeling. By modulating diverse signaling pathway...
A call to standardize the nomenclature of human fetal membrane at the feto-maternal interface [0.03%]
呼吁统一胎盘胎儿面膜性结构的命名标准
Claire E Kendal-Wright,John J Moore,Liping Feng et al.
Claire E Kendal-Wright et al.
Despite being one of the largest intrauterine tissues in surface area, the fetal membrane that lines the intrauterine cavity is often overlooked, forgotten, or misidentified in clinical and basic science research. The feto-maternal interfac...
Different risk of acute feto-fetal transfusion in basic clinical subtypes of monochorionic twins [0.03%]
单绒毛膜双胎基本临床亚型的急性胎儿间输血风险不同
Hašlík Lubomír,Gratacós Eduard,Petra Hanulíková et al.
Hašlík Lubomír et al.
Analysis of the potential risk of acute feto-fetal transfusion (aFFT) in different clinical types of monochorionic twins using an in vitro placental simulation model. The prospective study analyzed 157 fresh MC placentas from 2014 to 2020, ...
Single-cell RNA sequencing reveals systemic and placental immune landscape in preeclampsia [0.03%]
单细胞RNA测序揭示子痫前期的系统性和胎盘免疫图谱
Xingyu Wei,Kun Li,Shijing Lu et al.
Xingyu Wei et al.
Background: Preeclampsia (PE) is one of the most severe complications of pregnancy characterized by systemic and placental inflammation. Recently, studies have characterized the immune landscape in preeclampsia at single-...
Complement proteins, annexin V, and angiogenic markers in placental tissue of autoimmune disease patients [0.03%]
自身免疫性疾病患者胎盘组织中的补体蛋白、钙调神经磷酸酶V和血管生成标志物
Aleida Susana Castellanos Gutierrez,Paulina Fuentes-Zacarias,Núria Baños et al.
Aleida Susana Castellanos Gutierrez et al.
Introduction: Autoimmune diseases (AID) such as systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS) or non-criteria-obstetric antiphospholipid syndrome (NC-OAPS) increase the risk of adverse perinatal outc...
Lipopolysaccharide-induced subclinical infection affects pregnancy and impairs offspring development in an early gestation rat model [0.03%]
脂多糖诱导的亚临床感染影响妊娠并损害早期胎鼠发育
J S Beltrame,F Scheffer,V A Cañumil et al.
J S Beltrame et al.
Subclinical infections cause an imbalance of immune homeostasis that could have severe consequences for pregnancy and progeny development. We investigated if lipopolysaccharide (LPS)-induced subclinical infection affects vascular adaptation...
MALAT1 overexpression contributes to choriocarcinoma by binding with RBM10 and promoting p53 degradation [0.03%]
MALAT1通过与RBM10结合促进p53降解从而促发绒毛膜癌发生发展
Hui Li,Yan Feng,Panhong Fan et al.
Hui Li et al.
Background: Choriocarcinoma (CC), a highly aggressive and malignant subtype of gestational trophoblastic disease (GTD), arises from the dysregulated proliferation of trophoblastic cells, which normally mediate placental d...